Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Mitochondria-targeting conjugates as a new anticancer agents

2021/41/B/ST4/00088

Keywords:

synthesis antitumor activity drugs directed to mitochondria mechanism of action interdisciplinarity

Descriptors:

  • ST4_009:
  • NZ7_014:
  • NZ3_002:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Adam Włodzimierz Huczyński 

Number of co-investigators in the project: 6

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 1 534 300 PLN

Project start date (Y-m-d): 2022-01-12

Project end date (Y-m-d): 2025-12-11

Project duration:: 47 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Rate of translocation across lipid bilayer of triphenylphosphonium-linked salinomycin derivatives contributes significantly to their K+/H+ exchange activity on membranes
    Authors:
    Yuri N. Antonenko, Marta Jędrzejczyk, Tatyana I. Rokitskaya, Ljudmila S. Khailova, Elena A. Kotova, Adam Huczyński
    Academic press:
    Bioelectrochemistry (rok: 2022, tom: 145, strony: 108089), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2022.108089 - link to the publication
  2. Anticancer activity of salinomycin quaternary phosphonium salts
    Authors:
    Marta Jędrzejczyk, Michał Sulik, Magdalena Mielczarek-Puta, Gwan Yong Lim, Małgorzata Podsiad, Jakub Hoser, Piotr Bednarczyk, Marta Struga, Adam Huczyński,
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2025, tom: 282, strony: 117055), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2024.117055 - link to the publication

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