Mitochondria-targeting conjugates as a new anticancer agents

2021/41/B/ST4/00088

Keywords

Descriptors

ST4_009: Chemia biologiczna
NZ7_014: Farmacja, farmakoterapia, farmakologia
NZ3_002: Fizjologia komórki

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Adam Włodzimierz Huczyński

Number of co-investigators in the project: 6

Call

OPUS 21 – announced on 2021-03-15

Amount awarded: 1 534 300 PLN
Project start date: 2022-01-12
Project end date: 2025-12-11
Project duration: 47 months (the same as in the proposal)
Project status: Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

Anticancer activity of salinomycin quaternary phosphonium salts

Authors:
Marta Jędrzejczyk, Michał Sulik, Magdalena Mielczarek-Puta, Gwan Yong Lim, Małgorzata Podsiad, Jakub Hoser, Piotr Bednarczyk, Marta Struga, Adam Huczyński,

Academic press:
European Journal of Medicinal Chemistry (year: 2025, volume: 282, pages: 117055), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.ejmech.2024.117055 – link to the publication
Rate of translocation across lipid bilayer of triphenylphosphonium-linked salinomycin derivatives contributes significantly to their K+/H+ exchange activity on membranes

Authors:
Yuri N. Antonenko, Marta Jędrzejczyk, Tatyana I. Rokitskaya, Ljudmila S. Khailova, Elena A. Kotova, Adam Huczyński

Academic press:
Bioelectrochemistry (year: 2022, volume: 145, pages: 108089), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.bioelechem.2022.108089 – link to the publication

« New search

Projects search