Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Does DREADD and TrkB gene transfer targeted to selected motoneurons following spinal cord injury bring recovery of motor functions? Dependence between chemogenetic and neurotrophic activation and synaptic changes in motoneurons

2018/31/B/NZ4/02789

Keywords:

spinal cord transection DREADD BDNF-TrkB signaling synaptic plasticity improvement in motor function AAV vectors

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology
  • NZ4_10: Neuroimaging and computational neuroscience

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Skup 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 742 800 PLN

Project start date (Y-m-d): 2019-10-31

Project end date (Y-m-d): 2025-08-30

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling.
    Authors:
    Kamil Grycz, Anna Głowacka, Benjun Ji, Kamila Krzywdzińska, Agata Charzyńska, Julita Czarkowska-Bauch, Olga Gajewska-Woźniak, Małgorzata Skup
    Academic press:
    Experimental Neurology (rok: 2022, tom: 354, strony: 114098), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.expneurol.2022.114098 - link to the publication
  2. JERZY KONORSKI (1903–1973) – eksperymentator i teoretyk: od badań odruchów warunkowych do koncepcji jednostek gnostycznych
    Authors:
    Małgorzata Skup
    Academic press:
    KOSMOS (rok: 2020, tom: 69 (1), strony: 45428), Wydawca: Polskie Towarzystwo Przyrodników im. M. Kopernika; współwydawca: Wydawnictwo Naukowe Uniwersytetu Mikołaja Kopernika
    Status:
    Published
    DOI:
    brak - link to the publication
  3. BDNF Spinal Overexpression after Spinal Cord Injury Partially Protects Soleus Neuromuscular Junction from Disintegration, Increasing VAChT and AChE Transcripts in Soleus but Not Tibialis Anterior Motoneurons.
    Authors:
    Anna Głowacka, Benjun Ji, Andrzej A. Szczepankiewicz, Małgorzata Skup, Olga Gajewska-Woźnia
    Academic press:
    Biomedicines (rok: 2022, tom: 10, strony: 2851), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines - link to the publication
  4. Molecular Identification of Pro-Excitogenic Receptor and Channel Phenotypes of the Deafferented Lumbar Motoneurons in the Early Phase after SCT in Rats.
    Authors:
    Benjun Ji, Bartosz Wojtaś, Małgorzata Skup
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 11133), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231911133 - link to the publication
  5. Roles of palmitoylation in structural long-term synaptic plasticity
    Authors:
    Benjun Ji, Małgorzata Skup
    Academic press:
    Mol. Brain (rok: 2021, tom: 0,588888888888889, strony: 45318), Wydawca: BMC - Springer nature
    Status:
    Published
    DOI:
    10.1186/s13041-020-00717-y - link to the publication

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