Search results

1. Design and characterisation of sealing materials of prosthetic obturator being additionally a cytostatic drug reservoir.…

Principal investigator: prof. Anna Trusek

Politechnika Wrocławska

Call: OPUS 26, Panel: ST8

2. Three-phase drug carriers - design towards a prolonged release, development of a transport model and its verification. C…

Principal investigator: prof. Anna Trusek

Politechnika Wrocławska

Call: PRELUDIUM BIS 4, Panel: ST8

3. Drug Design: Chirality Measures as QSAR descriptors.

Principal investigator: Piotr Jakub Lipiński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Call: PRELUDIUM 3, Panel: NZ7

4. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design…

Principal investigator: Emilia Aleksandra Sługocka

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 22, Panel: NZ7

5. Towards the integrated molecular modelling – machine learning (MM-ML)" computational method for supporting the design of…

Principal investigator: prof. Tomasz Puzyn

Uniwersytet Gdański, Wydział Chemii

Call: SHENG 2, Panel: ST5

6. Combination of Molecular Simulation and Deep Learning for De Novo Drug Design

Principal investigator: dr Tomasz Jakub Danel

Uniwersytet Jagielloński, Wydział Matematyki i Informatyki

Call: PRELUDIUM 19, Panel: ST6

7. Design, bio and diversity oriented synthesis of fused pyridin-4(1H)-ones, 4H-pyrane-4-ones and 4H-thiopyran-4-ones as po…

Principal investigator: dr Satenik Mkrtchyan

Centrum Badań Molekularnych i Makromolekularnych PAN

Call: POLONEZ 2, Panel: ST5

8. Design, synthesis and analysis of electrospun materials based on biodegradable polymers as potential drug delivery syste…

Principal investigator: Marek Wojciech Rychter

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Nanobiomedyczne

Call: PRELUDIUM 9, Panel: ST8

9. Fentanyl opioid designer drugs: from molecular modeling to in vitro studies

Principal investigator: prof. Joanna Sadlej

Narodowy Instytut Leków

Call: OPUS 6, Panel: ST4

10. Design of enzyme systems for the study of chiral drugs with the use of superparamagnetic nanoparticles as carriers for b…

Principal investigator: dr Tomasz Siódmiak

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

Call: PRELUDIUM 5, Panel: NZ7

11. Computer aided design and prediction of properties of drug delivery systems based on carbon nanotubes architecture

Principal investigator: dr hab. Tomasz Pańczyk

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Call: SONATA BIS 2, Panel: ST4

12. Search for new "drug-like" molecules designed as adenosine receptors ligands

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: HARMONIA 2, Panel: NZ4

13. Homo- and heterometallic phosphine ruthenium and iridium complexes - design, synthesis, bioactivity and magnetic-nanofor…

Principal investigator: Sandra Amanda Kozieł

Uniwersytet Wrocławski, Wydział Chemii

Call: PRELUDIUM 19, Panel: ST4

14. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en…

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej PAN

Call: OPUS 19, Panel: NZ1

15. Personalized therapy - design and verification of the optimalization and manufacturing of the modified release, orally t…

Principal investigator: prof. Sebastian Polak

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 16, Panel: NZ7

16. Modeling of quantitative structure-metabolic stability relationships as a tool to improve design of potential novel anti…

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Call: OPUS 12, Panel: NZ7

17. Design and chemical synthesis of peptide-based conjugates with antimicrobial activity - a promising approach to improve …

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Call: OPUS 11, Panel: ST5

18. Design and synthesis of pH- and redox-responsive dimeric dendrons as a nanotools for transporting siRNA or drugs into gl…

Principal investigator: prof. Zofia Lipkowska

Instytut Chemii Organicznej Polska Akademia Nauk

Call: OPUS 10, Panel: ST5

19. Self-learning systems in the design of compounds modulating GPCR receptors activation.

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Call: OPUS 20, Panel: NZ2

20. Stealth" asparaginases as improved protein drugs for the treatment of childhood acute lymphoblastic leukemia (ALL)

Principal investigator: prof. Matthias Bochtler

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Call: OPUS 27, Panel: NZ1

21. Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N…

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej PAN

Call: OPUS 22, Panel: NZ7

22. Design and Pharmacological Evaluation of Marine Alkaloid-Inspired 5-HT2A Receptor Ligands

Principal investigator: Szymon Kazimierz Kordylewski

Instytut Farmakologii PAN

Call: PRELUDIUM 24, Panel: NZ1

23. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej PAN

Call: SONATA BIS 13, Panel: NZ7

24. Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Principal investigator: Alex Jun Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Call: PRELUDIUM 22, Panel: NZ7

25. Design, Synthesis and Characterization of Functionalized 1,2,4-Trioxanes/Trioxepanes for Antimalarial and Anticancer Use

Principal investigator: dr Mohit Kumar Tiwari

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Call: SONATINA 7, Panel: NZ7

26. Development of tools for the rational design of peptide therapeutics

Principal investigator: prof. Sebastian Kmiecik

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

Call: OPUS 20, Panel: NZ2

27. Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc…

Principal investigator: Alicja Aleksandra Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 19, Panel: NZ7

28. Rational design and evaluation of functionally biased opioid agonists

Principal investigator: prof. Ryszard Przewłocki

Instytut Farmakologii PAN

Call: OPUS 16, Panel: NZ7

29. Molecular picture of the mechanochemical coupling in ATP synthase as a conceptual framework for the development of novel…

Principal investigator: dr hab. Jacek Czub

Politechnika Gdańska, Wydział Chemiczny

Call: SONATA BIS 7, Panel: NZ2

30. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha…

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: SONATA 12, Panel: NZ7

31. Development of protocol for in silico design of compounds inhibit Ebola virus infection

Principal investigator: Dawid Zdzisław Warszycki

Instytut Farmakologii PAN

Call: PRELUDIUM 11, Panel: NZ2

32. Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: PRELUDIUM 22, Panel: NZ1

33. Structure-guided design of histone demethylase inhibitors for cancer therapy.

Principal investigator: dr Piotr Henryk Małecki

Instytut Chemii Bioorganicznej PAN

Call: SONATA 17, Panel: NZ7

34. Study of iron catalysis for the activation of carbon-hydrogen bonds: design of new reactions and their application in me…

Principal investigator: dr Michał Szostak

Uniwersytet Opolski, Wydział Chemii

Call: SONATA 8, Panel: ST5

35. Design and synthesis of the porous materials based on biopolymers and their composites with magnetite as potential sorbe…

Principal investigator: dr Anna Daria Kaczmarek-Kędziera

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Call: OPUS 7, Panel: ST8

36. Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

Principal investigator: dr Magdalena Piętka-Ottlik

Politechnika Wrocławska, Wydział Chemiczny

Call: SONATA 5, Panel: ST5

37. Novel DNA Minor Groove Helix Alkylating Agents - Design, Synthesis and Antitumor Activity Screening

Principal investigator: dr Adam Józef Mieczkowski

Instytut Biochemii i Biofizyki PAN

Call: OPUS 1, Panel: NZ4

38. "I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr…

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii PAN

Call: OPUS 25, Panel: NZ7

39. Bis(benzosiloxaboroles) as a new class of potential antibiotics - a perspective solution to growing problem of antimicro…

Principal investigator: Krzysztof Nowicki

Politechnika Warszawska, Wydział Chemiczny

Call: PRELUDIUM 22, Panel: ST5

40. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Call: OPUS 22, Panel: NZ7

41. Dual-Target Compounds Modulating EAAT2 and Kv7.2/3 Channels: A Rational Strategy Toward Novel Antiseizure and Antinocice…

Principal investigator: dr Michał Andrzej Abram

Uniwersytet Jagielloński

Call: OPUS 29, Panel: NZ7

42. NMR Spectroscopy as Molecular Language: A Deep Learning Approach to Bioactivity Prediction

Principal investigator: Arkadiusz Bogumił Leniak

Instytut Farmakologii PAN

Call: PRELUDIUM 24, Panel: NZ7

43. Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t…

Principal investigator: dr hab. Damian Nestor Plażuk

Uniwersytet Łódzki

Call: OPUS 27, Panel: NZ7

44. Taming aggregation with AmyloGraph 2.0: a database and prediction models of amyloid self-assembly modulators

Principal investigator: dr Michał Jan Burdukiewicz

Uniwersytet Medyczny w Białymstoku

Call: SONATA 19, Panel: NZ7

45. Decrypting the "sulfation code" of glycosaminoglycans for understanding their function in the extracellular matrix

Principal investigator: dr hab. Sergey Samsonov

Uniwersytet Gdański, Wydział Chemii

Call: OPUS 25, Panel: ST4

46. Targeted inhibition of hypusination pathway

Principal investigator: dr Przemysław Marek Grudnik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Call: OPUS 24, Panel: NZ7

47. Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap…

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Call: SONATA BIS 12, Panel: ST4

48. Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of…

Principal investigator: dr hab. Carlo Vascotto

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Call: OPUS 22, Panel: NZ5

49. The new methodology for better understanding of ligand-RNA interactions.

Principal investigator: dr Filip Artur Stefaniak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Call: OPUS 20, Panel: NZ2

50. Fluorine substitution – a new algorithm for increasing biological activity

Principal investigator: Wojciech Pietruś

Instytut Farmakologii PAN

Call: PRELUDIUM 18, Panel: NZ7

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