Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Personalized therapy - design and verification of the optimalization and manufacturing of the modified release, orally taken drugs with the use of the 3D printing, computational intelligence techniques and mechanistic pharmacokinetic modeling

2018/31/B/NZ7/03238

Keywords:

3D printing personalized therapy PBPK

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Sebastian Polak 

Number of co-investigators in the project: 10

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 2 445 000 PLN

Project start date (Y-m-d): 2019-10-02

Project end date (Y-m-d): 2023-10-01

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Development of physiologically based pharmacokinetic model for the immediate release of ropinirole tablets.
    Authors:
    Shuklinova O, Dorożyński P, Kulinowski P, Bielecka Z, Wiśniowska B, Polak S.
    Academic press:
    Acta Poloniae Pharmaceutica – Drug Research (rok: 2021, tom: 78, strony: 317-328), Wydawca: Polish Pharmaceutical Society
    Status:
    Published
    DOI:
    10.32383/appdr/137903 - link to the publication
  2. Pharmaceutical dosage forms by Vat Polymerization – from additive manufacturing to functional properties and formulation understanding
    Authors:
    Ewelina Baran, Artur Birczyński, Przemysław Dorożyński, Piotr Kulinowski
    Academic press:
    Macedonian pharmaceutical bulletin (rok: 2023, tom: 69, strony: 97-98), Wydawca: Macedonian Pharmaceutical Society
    Status:
    Published
    DOI:
    10.33320/maced.pharm.bull.2023.69.03.047 - link to the publication
  3. Quality control dissolution data is biopredictive for a modified release ropinirole formulation: virtual experiment with the use of re-developed and verified PBPK model.
    Authors:
    Shuklinova O, Dorożyński P, Kulinowski P, Polak S.
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14(7), strony: n.d.), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14071514 - link to the publication
  4. Development of physiologically based pharmacokinetic model for the immediate release of ropinirole tablets.
    Authors:
    Shuklinova O, Dorożyński P, Kulinowski P, Bielecka Z, Wiśniowska B, Polak S.
    Academic press:
    Acta Poloniae Pharmaceutica – Drug Research (rok: 2021, tom: 78, strony: 317-328), Wydawca: Polish Pharmaceutical Society
    Status:
    Published
    DOI:
    10.32383/appdr/137903 - link to the publication
  5. Selective laser sintering (SLS) technique for pharmaceutical applications—Development of high dose controlled release printlets.
    Authors:
    Piotr Kulinowski, Piotr Malczewski, Edyta Pesta, Marta Łaszcz, Aleksander Mendyk, Sebastian Polak, Przemysław Dorożyński
    Academic press:
    Additive Manufacturing (rok: 2021, tom: 38, strony: 101761), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.addma.2020.101761 - link to the publication
  6. Development of Composite, Reinforced, Highly Drug-Loaded Pharmaceutical Printlets Manufactured by Selective Laser Sintering—In Search of Relevant Excipients for Pharmaceutical 3D Printing
    Authors:
    Kulinowski, P.; Malczewski, P.; Łaszcz, M.; Baran, E.; Milanowski, B.; Kuprianowicz, M.; Dorożyński, P.
    Academic press:
    Materials (rok: 2022, tom: 15, strony: n.a.), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma - link to the publication
  7. 3D printing combined with biopredictive dissolution and PBPK/PD modeling optimization and personalization of pharmacotherapy. Are we there yet?
    Authors:
    Wyszogrodzka-Gaweł G, Shuklinova O, Lisowski B, Wiśniowska B, Polak S.
    Academic press:
    Drug Discovery Today (rok: 2023, tom: 28, strony: 103731), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.drudis.2023.103731 - link to the publication
  8. Can 3D Printed Tablets Be Bioequivalent and How to Test It: A PBPK Model Based Virtual Bioequivalence Study for Ropinirole Modified Release Tablets
    Authors:
    Olha Shuklinova, Gabriela Wyszogrodzka-Gaweł, Ewelina Baran, Bartosz Lisowski, Barbara Wiśniowska, Przemysław Dorożyński, Piotr Kulinowski, Sebastian Polak
    Academic press:
    Pharmaceutics (rok: 2024, tom: 16(2), strony: 259), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics16020259 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy