Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Study of iron catalysis for the activation of carbon-hydrogen bonds: design of new reactions and their application in medicinal chemistry and materials science.

2014/15/D/ST5/02731

Keywords:

iron palladium C-H bond activation arylation late-stage drug functionalization iterative C-H functionalization materials science medicinal chemistry

Descriptors:

  • ST5_23:
  • ST4_11: Coordination and supramolecular chemistry
  • ST4_12: Photochemistry

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Opolski, Wydział Chemii

woj. opolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Szostak 

Number of co-investigators in the project: 3

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 445 400 PLN

Project start date (Y-m-d): 2015-09-22

Project end date (Y-m-d): 2019-01-21

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wysokowydajna linia Schlenka o wysokiej próżni. (12 484 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  1. Barriers to rotation in ortho-substituted tertiary aromatic amides: Effect of chloro-substitution on resonance and distortion
    Authors:
    Elwira Bisz, Aleksandra Piontek, Błażej Dziuk, Roman Szostak, Michal Szostak
    Academic press:
    Journal of Organic Chemistry (rok: 2018, tom: 83, strony: 3159-3163), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.8b00019 - link to the publication
  2. Cyclic ureas (DMI, DMPU) as efficient, sustainable ligands in iron-catalyzed C(sp2)–C(sp3) coupling of aryl chlorides and tosylates
    Authors:
    Elwira Bisz, Michal Szostak
    Academic press:
    Green Chemistry (rok: 2017, tom: 19, strony: 5361-5366), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7gc02690k - link to the publication
  3. Iron-catalyzed C(sp2 )–C(sp3 ) cross-coupling at low catalyst loading
    Authors:
    Elwira Bisz, Marlena Kardela, Aleksandra Piontek, Michal Szostak
    Academic press:
    Catalysis Science & Technology (rok: 2019, tom: 9, strony: 1092-1097), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8cy02374c - link to the publication
  4. Iron-catalyzed C(sp2)−C(sp3) cross-coupling of chlorobenzamides with alkyl Grignard reagents: Development of catalyst system, synthetic scope, and application
    Authors:
    Elwira Bisz, Michal Szostak
    Academic press:
    Advanced Synthesis & Catalysis (rok: 2019, tom: 361, strony: 85-95), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/adsc.201800849 - link to the publication
  5. Iron-catalyzed cross-coupling in the synthesis of pharmaceuticals: In pursuit of sustainability
    Authors:
    Aleksandra Piontek, Elwira Bisz, Michal Szostak
    Academic press:
    Angewandte Chemie International Edition (rok: 2018, tom: 57, strony: 11116-11128), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/anie.201800364 - link to the publication
  6. Ligand effect on iron-catalyzed cross-coupling reactions: Evaluation of amides as O-coordinating ligands
    Authors:
    Elwira Bisz, Marlena Kardela, Michal Szostak
    Academic press:
    ChemCatChem (rok: 2019, tom: 11, strony: 5733-5737), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/cctc.201901150 - link to the publication
  7. 2-Methyltetrahydrofuran: A green solvent for iron-catalyzed cross-coupling reactions
    Authors:
    Elwira Bisz, Michal Szostak
    Academic press:
    ChemSusChem (rok: 2018, tom: 11, strony: 1290-1294), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/cssc.201800142 - link to the publication
  8. N-Methylcaprolactam as a dipolar aprotic solvent for iron-catalyzed cross-coupling reactions: Matching efficiency with safer reaction media
    Authors:
    Elwira Bisz, Pamela Podchorodecka, Michal Szostak
    Academic press:
    ChemCatChem (rok: 2019, tom: 11, strony: 1196-1199), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/cctc.201802032 - link to the publication
  9. Biphenyl-4-yl 4-methylbenzenesulfonate
    Authors:
    Aleksandra Olszowy, Dawid Siodłak, Bartosz Zarychta
    Academic press:
    IUCrData (rok: 2017, tom: -, strony: -), Wydawca: International Union of Crystallography
    Status:
    Published
    DOI:
    10.1107/S2414314617009828 - link to the publication
  10. Structures and energetic properties of 4-halobenzamides
    Authors:
    Aleksandra Piontek, Elwira Bisz, Błażej Dziuk, Roman Szostak, Michal Szostak
    Academic press:
    Acta Crystallographica Section C-Structural Chemistry (rok: 2018, tom: 74, strony: 1395-1402), Wydawca: International Union of Crystallography
    Status:
    Published
    DOI:
    10.1107/S2053229618013463 - link to the publication
  11. 3,5-Bis(trifluoromethyl)phenyl 4-methylbenzene- sulfonate
    Authors:
    Aleksandra Olszowy, Dawid Siodłak, Bartosz Zarychta
    Academic press:
    IUCrData (rok: 2017, tom: -, strony: -), Wydawca: International Union of Crystallography
    Status:
    Published
    DOI:
    10.1107/S2414314617009816 - link to the publication
  12. 3,5-Dimethoxyphenyl 4-methylbenzenesulfonate
    Authors:
    Aleksandra Olszowy, Dawid Siodłak, Bartosz Zarychta
    Academic press:
    IUCrData (rok: 2017, tom: -, strony: -), Wydawca: International Union of Crystallography
    Status:
    Published
    DOI:
    10.1107/S2414314617009804 - link to the publication
  13. Iron-catalyzed C(sp2)-C(sp3) cross-coupling of alkyl Grignard reagents with polyaromatic tosylates
    Authors:
    Aleksandra Piontek, Michal Szostak
    Academic press:
    European Journal of Organic Chemistry (rok: 2017, tom: 2017, strony: 7271-7276), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/ejoc.201701654 - link to the publication
  14. Iron-catalyzed C(sp2)-C(sp3) cross-coupling of chlorobenzenesulfonamides with alkyl Grignard reagents: Entry to alkylated aromatics
    Authors:
    Elwira Bisz, Michał Szostak
    Academic press:
    Journal of Organic Chemistry (rok: 2019, tom: 84, strony: 1640-1646), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.8b02886 - link to the publication
  15. Iron-catalyzed C-O bond activation: Opportunity for sustainable catalysis
    Authors:
    Elwira Bisz, Michal Szostak
    Academic press:
    ChemSusChem (rok: 2017, tom: 10, strony: 3964-3981), Wydawca: Wiley-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/cssc.201701287 - link to the publication

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