Projects funded by the NCN
Novel DNA Minor Groove Helix Alkylating Agents - Design, Synthesis and Antitumor Activity Screening
2011/01/B/NZ4/03566
Keywords:
anticancer drugs anthramycin DNA minor groove DNA alkylating agents solid-phase synthesis fused benzodiazepines experimental oncology pharmacology apoptosis cell cycle cancer cell lines palladium catalyzed reactions
Descriptors:
- NZ4_17:
- ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
- ST5_23:
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Instytut Biochemii i Biofizyki PAN
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 1 - announced on 2011-03-15
Amount awarded: 299 000 PLN
Project start date (Y-m-d): 2011-12-16
Project end date (Y-m-d): 2015-12-15
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (2)
- (S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione—Synthesis and Crystallographic StudiesAuthors:Adam Mieczkowski, Damian Trzybiński, Marcin Wilczek, Mateusz Psurski, Maciej Bagiński, Bartosz Bieszczad, Magdalena Mroczkowska, Krzysztof WoźniakAcademic press:Molbank (open access) (rok: 2017, tom: 2017, strony: 45297), Wydawca: MDPI ( Multidisciplinary Digital Publishing Institute)Status:PublishedDOI:10.3390/M964 - link to the publication
- Novel (S)-1,3,4,12a-tetrahydropyrazino[2,1-c][1,4]benzodiazepine-6,12(2H,11H)-dione derivatives: Selective inhibition of MV-4-11 biphenotypic B myelomonocytic leukemia cells' growth is accompanied by reactive oxygen species overproduction and apoptosisAuthors:Adam Mieczkowski, Mateusz Psurski, Maciej Bagiński, Bartosz Bieszczad, Magdalena Mroczkowska, Marcin Wilczek, Joanna Czajkowska, Damian Trzybiński, Krzysztof Woźniak, Joanna WietrzykAcademic press:Bioorganic & Medicinal Chemistry Letters (rok: 2018, tom: 28, strony: dostępne po wydrukowaniu przez wydawnictwo), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bmcl.2018.01.034 - link to the publication