Projects funded by the NCN

Bigels with controlled release of hydrophilic and hydrophobic therapeutic compounds as potential dressings in the treatm...

Call: OPUS 25 , Panel: ST11

Principal investigator: dr hab. Monika Gosecka

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Targeting undruggable proteins involved in tumorigenesis – developing and characterization of advanced nanoplatform for ...

Call: OPUS 25 , Panel: NZ6

Principal investigator: dr hab. Monika Bzowska

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Bitechnologii

Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian b...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Bernadeta Pietrzak-Wawrzyńska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Therapeutic self-understanding

Call: SONATA 18 , Panel: HS1

Principal investigator: dr Jędrzej Grodniewicz

Uniwersytet Jagielloński, Centrum Kopernika Badań Interdyscyplinarnych Uniwersytetu Jagiellońskiego

Specific immune signatures of T cells as biomarkers of the post-COVID Syndrome and predictors of long-term health dysfun...

Call: PRELUDIUM BIS 4 , Panel: NZ6

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Molecular insights into hypoxic tumors – for development of targeted cancer therapeutics

Call: POLONEZ BIS 3 , Panel: NZ5

Principal investigator: dr Marco Deiana

Politechnika Wrocławska

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr Karolina Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Łukasz Kurach

Uniwersytet Medyczny w Lublinie

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The therapeutic effect of activated human amniotic epithelial cells and conditioned medium enriched in exosomes in exper...

Call: PRELUDIUM 21 , Panel: NZ5

Principal investigator: Mateusz Król

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

Call: OPUS 23 , Panel: NZ5

Principal investigator: dr hab. Urszula Mackiewicz

Centrum Medyczne Kształcenia Podyplomowego

Chemical and surgical castration of sex offenders - effective punishment, therapeutic measure or dehumanizing torture? A...

Call: PRELUDIUM 21 , Panel: HS5

Principal investigator: Katarzyna Jakubczak-Fopke

Uniwersytet Gdański, Wydział Prawa i Administracji

Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Karolina Przepiórska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Magdalena Białoń

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Targeting of metabolic and transcriptomic cross-talk between leukemic cells and macrophages as a therapeutic strategy in...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Baran Natalia

Instytut Hematologii i Transfuzjologii

Mechanisms and consequences of CD19 loss in B-acute lymphoblastic leukaemia patients relapsing after CD19-CAR-T cell the...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Targeting UDP-glucose and P2Y14 receptor interaction for therapeutic modulation of inflammatory lung diseases

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Tadeusz Karcz

Uniwersytet Jagielloński, Collegium Medicum

Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Maciej Szydłowski

Instytut Hematologii i Transfuzjologii

Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Kamil Przyborowski

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Targeting of HSF1 as a therapeutic approach to inhibit the progression of hormone-dependent breast cancer.

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Natalia Vydra

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach

New immunomodulators of BTLA-HVEM complex as potential therapeutics in systemic lupus erythematosus

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Anna Wardowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Identification and therapeutic targeting of the mRNA splicing alteration mechanisms driven by gain-of-function TP53 muta...

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Magdalena Oroń

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Searching for new therapeutic targets in polyglutamine diseases

Call: OPUS 22 , Panel: NZ2

Principal investigator: dr hab. Marta Olejniczak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

P-stereodefined phosphorothioate analogs of 'morpholino" oligonucleotides (sTMO) as a new model of therapeutic nucleic a...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Katarzyna Jastrzębska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Non-provitamin A carotenoids as a novel therapeutic strategy in intestinal failure associated liver disease (IFALD)

Call: PRELUDIUM BIS 3 , Panel: NZ7

Principal investigator: dr hab. Maciej Stawny

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

efFect of nanoscale, three dimensIonal arrangement of proteins on biological and Therapeutic activity (FIT)

Call: OPUS 22 (LAP) , Panel: NZ1

Principal investigator: dr hab. Jonathan Heddle

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

The roles and therapeutic potential of distinct dystrophin and utrophin isoforms in the central and peripheral nervous s...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Patryk Konieczny

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Proline metabolism as a novel therapeutic target for diseases associated with mitochondrial dysfunction.

Call: SONATA BIS 11 , Panel: NZ3

Principal investigator: dr Karolina Szczepanowska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Anna Marusiak

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Role of Mcpip1 in biliary pathobiology: new potential therapeutic opportunities

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Jerzy Kotlinowski

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Improvement of therapeutic safety of parenteral nutrition in cancer patients - the interplay between supportive drugs an...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Szymon Tomczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

New type of analogs and conjugates of folic acid with potential therapeutic applicaton in treatment of hormone-dependent...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Olga Ciupak

Politechnika Gdańska, Wydział Chemiczny

Assessment of SARS-CoV-2 infection in patients with chronic lymphocytic leukemia depending on indicators of immune disor...

Call: OPUS 21 , Panel: NZ6

Principal investigator: prof. Ewelina Grywalska

Uniwersytet Medyczny w Lublinie

Effect of SSR 504734, a selective glycine transporter type 1 inhibitor, on seizure activity and therapeutic efficacy of ...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Piotr Wlaź

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Investigation of a new therapeutic strategy to lower mutant protein in SCA3 / MJD

Call: OPUS 21 , Panel: NZ2

Principal investigator: dr hab. Maciej Figiel

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Psychedelics as Therapeutic Candidates in Neurodegenerative Disorders Treatment– a Study in Spinocerebellar Ataxia Type ...

Call: SONATINA 5 , Panel: NZ4

Principal investigator: dr Urszula Kozłowska

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

Call: SONATINA 5 , Panel: ST4

Principal investigator: dr Magdalena Wiloch

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Małgorzata Kajta

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Development of tools for the rational design of peptide therapeutics

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Sebastian Kmiecik

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

Polymersomes specifically releasing cGAMP and doxorubicin in tumor hypoxic regions as a new anti-cancer therapeutic stra...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr Ryszard Smolarczyk

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach

Mechanism of splicing of MBNL1 transcript and its implications for potential therapeutic strategies for myotonic dystrop...

Call: SONATA 16 , Panel: NZ3

Principal investigator: dr Katarzyna Taylor

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Vitreous Optical Tomography for objective diagnosis, monitoring and outcome measures of therapeutic interventions for vi...

Call: SONATA 16 , Panel: NZ5

Principal investigator: dr Daniel Rumiński

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Toxic RNA with expanded trinucleotide repeats: pathomechanism and therapeutic targets of neurological diseases

Call: MAESTRO 12 , Panel: NZ3

Principal investigator: prof. Krzysztof Sobczak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

In vitro models for therapeutic proteins secretion in avian oviduct epithelial cells.

Call: PRELUDIUM 2 , Panel: NZ9

Principal investigator: dr Katarzyna Stadnicka

Uniwersytet Technologiczno-Przyrodniczy im. Jana i Jędrzeja Śniadeckich w Bydgoszczy, Wydział Hodowli i Biologii Zwierząt

Modulation of immune cells activity in the tumor microenvironment by oligonucleotide therapeutics delivered by silk nano...

Call: OPUS 19 , Panel: NZ6

Principal investigator: dr hab. Hanna Dams-Kozłowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

The significance of circadian rhythm in urinary bladder cancer: deregulation of circadian genes as a putative therapeuti...

Call: OPUS 19 , Panel: NZ5

Principal investigator: prof. Edyta Reszka

Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera

DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Therapeutic activation and signalling determinants of the autoregulatory MBNL1 expression in myotonic dystrophy.

Call: OPUS 19 , Panel: NZ5

Principal investigator: dr Ewa Stępniak-Konieczna

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii