Projects funded by the NCN


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194 projects found matching your search criteria :

  1. Mechanisms and consequences of CD19 loss in B-acute lymphoblastic leukaemia patients relapsing after CD19-CAR-T cell the...

    Call: PRELUDIUM BIS 3 , Panel: NZ5

    Principal investigator: prof. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  2. Targeting UDP-glucose and P2Y14 receptor interaction for therapeutic modulation of inflammatory lung diseases

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Tadeusz Piotr Karcz

    Uniwersytet Jagielloński, Collegium Medicum

  3. Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr Maciej Stefan Szydłowski

    Instytut Hematologii i Transfuzjologii

  4. Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Kamil Przyborowski

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  5. Targeting of HSF1 as a therapeutic approach to inhibit the progression of hormone-dependent breast cancer.

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr Natalia Vydra

    Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

  6. New immunomodulators of BTLA-HVEM complex as potential therapeutics in systemic lupus erythematosus

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Anna Wardowska

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  7. Identification and therapeutic targeting of the mRNA splicing alteration mechanisms driven by gain-of-function TP53 muta...

    Call: SONATA 17 , Panel: NZ5

    Principal investigator: dr Magdalena Oroń

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  8. Searching for new therapeutic targets in polyglutamine diseases

    Call: OPUS 22 , Panel: NZ2

    Principal investigator: prof. Marta Olejniczak

    Instytut Chemii Bioorganicznej PAN

  9. P-stereodefined phosphorothioate analogs of morpholino" oligonucleotides (sTMO) as a new model of therapeutic nucleic ac...

    Call: SONATA 17 , Panel: ST4

    Principal investigator: dr Katarzyna Jastrzębska

    Centrum Badań Molekularnych i Makromolekularnych PAN

  10. Non-provitamin A carotenoids as a novel therapeutic strategy in intestinal failure associated liver disease (IFALD)

    Call: PRELUDIUM BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Maciej Jan Stawny

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  11. efFect of nanoscale, three dimensIonal arrangement of proteins on biological and Therapeutic activity (FIT)

    Call: OPUS 22 (LAP) , Panel: NZ1

    Principal investigator: dr Antonina Naskalska

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  12. The roles and therapeutic potential of distinct dystrophin and utrophin isoforms in the central and peripheral nervous s...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr hab. Patryk Konieczny

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  13. Proline metabolism as a novel therapeutic target for diseases associated with mitochondrial dysfunction.

    Call: SONATA BIS 11 , Panel: NZ3

    Principal investigator: dr Karolina Szczepanowska

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  14. Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

    Call: SONATA BIS 11 , Panel: NZ5

    Principal investigator: dr Anna Agnieszka Marusiak

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  15. Role of Mcpip1 in biliary pathobiology: new potential therapeutic opportunities

    Call: SONATA BIS 11 , Panel: NZ5

    Principal investigator: dr Jerzy Kotlinowski

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  16. Improvement of therapeutic safety of parenteral nutrition in cancer patients - the interplay between supportive drugs an...

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: Szymon Tomczak

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  17. New type of analogs and conjugates of folic acid with potential therapeutic applicaton in treatment of hormone-dependent...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Olga Ciupak

    Politechnika Gdańska, Wydział Chemiczny

  18. Assessment of SARS-CoV-2 infection in patients with chronic lymphocytic leukemia depending on indicators of immune disor...

    Call: OPUS 21 , Panel: NZ6

    Principal investigator: prof. Ewelina Pia Grywalska

    Uniwersytet Medyczny w Lublinie

  19. Effect of SSR 504734, a selective glycine transporter type 1 inhibitor, on seizure activity and therapeutic efficacy of ...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Piotr Wiktor Wlaź

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  20. Investigation of a new therapeutic strategy to lower mutant protein in SCA3 / MJD

    Call: OPUS 21 , Panel: NZ2

    Principal investigator: prof. Maciej Figiel

    Instytut Chemii Bioorganicznej PAN

  21. Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

    Call: OPUS 21 , Panel: NZ5

    Principal investigator: dr hab. Katarzyna Piwocka

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  22. Psychedelics as Therapeutic Candidates in Neurodegenerative Disorders Treatment– a Study in Spinocerebellar Ataxia Type ...

    Call: SONATINA 5 , Panel: NZ4

    Principal investigator: dr Urszula Joanna Kozłowska

    Instytut Chemii Bioorganicznej PAN

  23. Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

    Call: SONATINA 5 , Panel: ST4

    Principal investigator: dr Magdalena Zofia Wiloch

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  24. Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kajta

    Instytut Farmakologii PAN

  25. Development of tools for the rational design of peptide therapeutics

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr hab. Sebastian Kmiecik

    Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

  26. Polymersomes specifically releasing cGAMP and doxorubicin in tumor hypoxic regions as a new anti-cancer therapeutic stra...

    Call: OPUS 20 , Panel: NZ5

    Principal investigator: dr hab. Ryszard Smolarczyk

    Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

  27. Mechanism of splicing of MBNL1 transcript and its implications for potential therapeutic strategies for myotonic dystrop...

    Call: SONATA 16 , Panel: NZ3

    Principal investigator: dr Katarzyna Magdalena Taylor

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  28. Vitreous Optical Tomography for objective diagnosis, monitoring and outcome measures of therapeutic interventions for vi...

    Call: SONATA 16 , Panel: NZ5

    Principal investigator: dr Daniel Rumiński

    Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  29. Toxic RNA with expanded trinucleotide repeats: pathomechanism and therapeutic targets of neurological diseases

    Call: MAESTRO 12 , Panel: NZ3

    Principal investigator: prof. Krzysztof Sobczak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  30. Modulation of immune cells activity in the tumor microenvironment by oligonucleotide therapeutics delivered by silk nano...

    Call: OPUS 19 , Panel: NZ6

    Principal investigator: prof. Hanna Dams-Kozłowska

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  31. Immunogenicity of plant-produced chimeric Virus-Like Particles formed byHBcAg displaying HBsAg epitopes for potential th...

    Call: POLS , Panel: NZ7

    Principal investigator: dr Benita Ortega Berlanga

    Instytut Genetyki Roślin PAN

  32. The significance of circadian rhythm in urinary bladder cancer: deregulation of circadian genes as a putative therapeuti...

    Call: OPUS 19 , Panel: NZ5

    Principal investigator: prof. Edyta Wiesława Reszka

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  33. DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Tomasz Adam Śliwiński

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  34. Therapeutic activation and signalling determinants of the autoregulatory MBNL1 expression in myotonic dystrophy.

    Call: OPUS 19 , Panel: NZ5

    Principal investigator: dr Ewa Agnieszka Stępniak-Konieczna

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

  35. Screening for new therapeutic targets in inherited retinal diseases based on protein-protein interactions analysis

    Call: POLS , Panel: NZ4

    Principal investigator: dr Xiaonan Liu

    Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

  36. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

    Call: OPUS 19 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej PAN

  37. Understanding of the mesenchymal stem cells (MSCs)-mediated immune suppression mechanism in the neutrophilic experimenta...

    Call: PRELUDIUM 19 , Panel: NZ5

    Principal investigator: dr Marlena Tynecka

    Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

  38. Assessment of therapeutic value and usefulness of new generation antibiotics and their metabolites as resistance markers...

    Call: PRELUDIUM 19 , Panel: ST4

    Principal investigator: Katarzyna Joanna Pauter-Iwicka

    Uniwersytet Mikołaja Kopernika, Wydział Chemii

  39. Antisense oligonucleotides and their nanostructures conjugated with boron clusters; physico-chemical and biological char...

    Call: ETIUDA 8 , Panel: ST4

    Principal investigator: Damian Mateusz Kaniowski

    Centrum Badań Molekularnych i Makromolekularnych PAN

  40. Improving the healing potential of therapeutic proteins by planned, specific modifiactions on the example of bacteriolyt...

    Call: PRELUDIUM 18 , Panel: NZ6

    Principal investigator: Marek Harhala

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  41. Dynamina-2 jako potencjalny cel terapeutyczny w chłoniaku rozlanym z dużych komórek B

    Call: SONATA 15 , Panel: NZ5

    Principal investigator: dr Patryk Górniak

    Instytut Hematologii i Transfuzjologii

  42. Improving therapeutic efficacy of anti-CD20 antibodies in precursor B-cell acute lymphoblastic leukemia

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr Małgorzata Firczuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  43. The influence of EGFRvIII structure and its cellular distribution heterogeneity on designing new therapeutic and diagnos...

    Call: OPUS 18 , Panel: NZ3

    Principal investigator: prof. Piotr Rieske

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  44. Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

    Instytut Farmakologii PAN

  45. Exploring influence of inorganic cell microenvironment on NO signalling deregulation in age-related disorders. From mole...

    Call: OPUS 18 , Panel: ST4

    Principal investigator: prof. Grażyna Jolanta Stochel

    Uniwersytet Jagielloński, Wydział Chemii

  46. The 'omics' of renal cancer nucleolus: towards identification of new cancer markers and therapeutic targets.

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: prof. Agnieszka Piekiełko-Witkowska

    CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO, Szkoła Nauk Medycznych

  47. Therapeutic application of temporin derivatives in infectious diseases caused by intracellular pathogens.

    Call: SONATA 15 , Panel: NZ6

    Principal investigator: dr Anna Golda

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  48. Predicting microbiome changes over time and upon perturbation: applications of machine learning to microbiome research a...

    Call: SONATA 15 , Panel: NZ2

    Principal investigator: dr Tomasz Piotr Kościółek

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  49. Testing of cation carrier derivatives as prospective therapeutic agents for the treatment of B-cell-derived malignancies...

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr Beata Pyrzyńska

    Warszawski Uniwersytet Medyczny, Wydział Lekarski

  50. Exploring the role and therapeutic potential of sex hormone binding globulin (SHBG) in the course of insulin resistance,...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: prof. Krzysztof Mariusz Marycz

    Uniwersytet Przyrodniczy we Wrocławiu, Wydział Biologii i Hodowli Zwierząt