Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of enzymes with dual implications for drug design

2020/37/B/NZ1/03250

Keywords:

asparaginase leukemia fungal infections enzyme inhibitors protein crystallography

Descriptors:

  • NZ1_004:
  • NZ1_002:
  • NZ1_005:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Jaskólski 

Number of co-investigators in the project: 7

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 2 347 200 PLN

Project start date (Y-m-d): 2021-02-01

Project end date (Y-m-d): 2026-01-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center
    Authors:
    J.I.Loch, P.Worsztynowicz, J.Sliwiak, M.Grzechowiak, B.Imiolczyk, K.Pokrywka, M.Chwastyk, M.Gilski, M.Jaskolski
    Academic press:
    Acta Cryst. D (tom: D79, strony: 775-791), Wydawca: IUCr Journals
    Status:
    Published
    DOI:
    10.1107/S2059798323005648 - link to the publication
  2. Massive annotation of bacterial l-asparaginases reveals their puzzling distribution and frequent gene transfer events
    Authors:
    3 A.Zielezinski, J.Loch, W.M.Karłowski, M.Jaskolski
    Academic press:
    Nature (tom: nie dotyczy, strony: nie dotyczy), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-19689-1 - link to the publication
  3. Structural and biophysical aspects of l-asparaginases: a growing family with amazing diversity
    Authors:
    1 J.Loch, M.Jaskolski
    Academic press:
    IUCRJ (), Wydawca: INT UNION CRYSTALLOGRAPHY
    Status:
    Published
    DOI:
    10.1107/S2052252521006011 - link to the publication
  4. Crystal structures of the elusive Rhizobium etli l-asparaginase reveal a peculiar active site
    Authors:
    2 J.I.Loch, B.Imiolczyk, J.Sliwiak, A.Wantuch, M.Bejger, M.Gilski, M.Jaskolski
    Academic press:
    NATURE COMMUNICATIONS (), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41467-021-27105-x - link to the publication

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