Projects funded by the NCN
Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC compounds
2021/42/E/NZ5/00227
Keywords:
breast cancer kinases cellular signalling PROTAC
Descriptors:
- NZ5_3: Pathogenesis of human diseases
- NZ3_7: Signal transduction
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk
woj.
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: SONATA BIS 11 - announced on 2021-06-15
Amount awarded: 4 035 160 PLN
Project start date (Y-m-d): 2022-03-24
Project end date (Y-m-d): 2027-03-23
Project duration:: 60 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Drivers of cancer metastasis - Arise early and remain presentAuthors:Dagmara Dymerska, Anna MarusiakAcademic press:BBA Reviews on Cancer (rok: 2023, tom: 1879, strony: 189060), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bbcan.2023.189060 - link to the publication
- PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.Authors:Torres-Ayuso, P., Katerji, M., Mehlich, D., Lookingbill, S. A., Sabbasani, V. R., Liou, H., Casillas, A. L., Chauhan, S. S., Serwa, R., Rubin, M. R., Marusiak, A. A., Swenson, R. E., Warfel, N. A., Brognard, JAcademic press:Cell Chemical Biology (rok: 2024, tom: 31, strony: 45669), Wydawca: Elsevier LtdStatus:PublishedDOI:10.023 - link to the publication