Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Improving the healing potential of therapeutic proteins by planned, specific modifiactions on the example of bacteriolytic lysins.

2019/35/N/NZ6/02564

Keywords:

endolysins modifications therapeutical proteins

Descriptors:

  • NZ6_5: Virology
  • NZ6_4: Bacteriology
  • NZ1_1: Molecular biology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

Marek Harhala 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 140 000 PLN

Project start date (Y-m-d): 2020-06-25

Project end date (Y-m-d): 2024-06-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins
    Authors:
    Marek Harhala, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna Kaźmierczak, Joanna Majewska, Daniel C. Nelson and Krystyna Dąbrowska
    Academic press:
    Frontiers in Microbiology (rok: 2021, tom: 12, strony: 3129-3138), Wydawca: Frontiers in Microbiology
    Status:
    Published
    DOI:
    10.3389/fmicb.2021.752282 - link to the publication
  2. Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses
    Authors:
    Marek Adam Harhala, Katarzyna Gembara, Izabela Rybicka, Zuzanna Maria Kaz´mierczak, Paulina Miernikiewicz, Joanna Marta Majewska, Wiktoria Budziar , Anna Nasulewicz-Goldeman, Daniel C. Nelson, Barbara Owczarek, Krystyna Dąbrowska
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 45670), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1075774 - link to the publication
  3. DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins
    Authors:
    Marek Harhala, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna Kaźmierczak, Joanna Majewska, Daniel C. Nelson and Krystyna Dąbrowska
    Academic press:
    Frontiers in Microbiology (rok: 2021, tom: 12, strony: 3129-3138), Wydawca: Frontiers in Microbiology
    Status:
    Published
    DOI:
    10.3389/fmicb.2021.752282 - link to the publication
  4. DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins
    Authors:
    Marek Harhala, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna Kaźmierczak, Joanna Majewska, Daniel C. Nelson and Krystyna Dąbrowska
    Academic press:
    Frontiers in Microbiology (rok: 2021, )
    Status:
    Published
    DOI:
    10.3389/fmicb.2021.752282 - link to the publication

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