Projects funded by the NCN
Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic Alzheimer's Disease
2020/39/B/NZ7/00974
Keywords:
Alzheimer's disease neurodegeneration neuroprotection estrogen receptors
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
- NZ3_5: Molecular neurobiology
- NZ7_12: Prevention of human diseases
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
woj.
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 20 - announced on 2020-09-15
Amount awarded: 1 451 800 PLN
Project start date (Y-m-d): 2021-07-27
Project end date (Y-m-d): 2024-07-26
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer's Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific GenesAuthors:Pietrzak-Wawrzyńska BA, Wnuk A, Przepiórska-Drońska K, Łach A, Kajta MAcademic press:Mol Neurobiol (rok: 2023, tom: praca dostępna, ale bez podania nr tomu, strony: praca dostępna, ale bez podania nr stron), Wydawca: SpringerStatus:PublishedDOI:10.1007/s12035-023-03819-5 - link to the publication