Projects funded by the NCN

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100 projects found matching your search criteria :

  1. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Anna Więckowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  2. Analysis and evaluation of the effectiveness of anorexic and safety properties for the new histamine H3 receptor ligands

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Magdalena Kotańska

    Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  3. Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic st...

    Call: HARMONIA 9 , Panel: NZ7

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  4. New derivatives of clopidogrel - enantioselective biosynthesis and antiplatelet activity in vitro

    Call: PRELUDIUM 14 , Panel: NZ7

    Principal investigator: Adam Sikora

    Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

  5. Prognostic value of platelet-derived microRNAs in patients with acute coronary syndrome treated with novel P2Y12 recepto...

    Call: PRELUDIUM 16 , Panel: NZ7

    Principal investigator: dr hab. Aleksandra Gąsecka-van der Pol

    Warszawski Uniwersytet Medyczny, I Wydział Lekarski

  6. Anticancer Trojan horses: Application of the bioconjugation idea to invent new anticancer drugs

    Call: UWERTURA 3 , Panel: ST4

    Principal investigator: dr Michał Antoszczak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  7. LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Paweł Zajdel

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  8. Henryk Sienkiewicz. Presence in 20th century Polish culture. Reception and new readings.

    Call: MAESTRO 3 , Panel: HS2

    Principal investigator: prof. Tadeusz Bujnicki

    Uniwersytet Warszawski, Wydział "Artes Liberales"

  9. PHARMACOTHERAPY OF OSTEOARTHRITIS: TRPV1 AND CB1 RECEPTORS AND THEIR ENDOGENOUS LIGANDS AS NEW TARGETS FOR PHARMACOLOGIC...

    Call: SONATA BIS 2 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Starowicz-Bubak

    Instytut Farmakologii PAN

  10. The role of sphingosine-1-phosphate (S1P) receptors signaling in animal model of Parkinson disease. Searching of novel t...

    Call: PRELUDIUM 5 , Panel: NZ4

    Principal investigator: Joanna Motyl

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  11. Targeting peripheral cannabinoid receptors CB2 as a novel therapy to treat osteoarthritis

    Call: OPUS 7 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Starowicz-Bubak

    INSTYTUT FARMAKOLOGII PAN

  12. Non-quinazoline antagonists of apha1 and 5-HT2A receptors with pleiotropic effects as a new perspective for hypertension...

    Call: SONATA 8 , Panel: NZ7

    Principal investigator: dr Monika Kubacka

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  13. Porphyromonas gingivalis protein and its homologs from other periodontopathogens - a novel group of bacterial virulence ...

    Call: OPUS 9 , Panel: NZ6

    Principal investigator: prof. Teresa Olczak

    Uniwersytet Wrocławski, Wydział Biotechnologii

  14. Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

    Call: OPUS 9 , Panel: ST5

    Principal investigator: prof. Maria Bretner

    Politechnika Warszawska, Wydział Chemiczny

  15. Searching for the new lead structures for 5-HT7 serotonin receptor ligands with increased metabolic stability.

    Call: HARMONIA 7 , Panel: NZ7

    Principal investigator: Sabina Podlewska

    Instytut Farmakologii PAN

  16. Search for the functionally selective 5-HT1A receptor agonists as new pharmacological tools in the development of treatm...

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: prof. Marcin Kołaczkowski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  17. Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Paweł Zajdel

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  18. Novel role of peroxisome proliferator-activated receptor α in the regulationof amyloid β peptide metabolism and mitochon...

    Call: PRELUDIUM 18 , Panel: NZ4

    Principal investigator: dr Sylwia Żulińska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  19. Dual histamine H3 and sigma-1 receptor ligands as novel pharmacological tools in the treatment of central nervous system...

    Call: SONATINA 4 , Panel: NZ7

    Principal investigator: Katarzyna Anna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  20. A novel approach based on the optimized multidrug combination for glioblastoma treatment.

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr hab. Małgorzata Kucińska

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  21. Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kajta

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  22. Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

    Uniwersytet Gdański, Wydział Chemii

  23. Novel combination therapies of pulmonary arterial hypertension targeting blockade of peripheral cannabinoid CB1 receptor...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Barbara Malinowska

    Uniwersytet Medyczny w Białymstoku

  24. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  25. Novel receptor materials for the construction of a bioelectronic nose for the rapid and efficient detection of lung canc...

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Wojciech Kamysz

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  26. Unraveling protease activation in stimulated CAR-T cells to identify new biomarkers for assessing their clinical efficac...

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr hab. Małgorzata Firczuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  27. Study on novel sensing layers for determination of quorum sensing signal molecules

    Call: SONATA BIS 13 , Panel: ST5

    Principal investigator: dr hab. Kamila Sadowska

    Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk

  28. Recognition of expression and function of new neuropeptide - phoenixin-14 in porcine corpus luteum.

    Call: PRELUDIUM 19 , Panel: NZ9

    Principal investigator: Ewa Maria Mlyczyńska

    Uniwersytet Jagielloński, Wydział Biologii

  29. New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: dr Przemysław Patryk Zaręba

    Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

  30. The role of somatostatin- and parvalbumin interneurons in the modulation of neuronal function and synaptic plasticity vi...

    Call: OPUS 20 , Panel: NZ4

    Principal investigator: dr hab. Joanna Małgorzata Urban-Ciećko

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  31. New approach to the treatment of Alzheimer's disease targetingresolution of inflammation and modulation of biomechanical...

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  32. Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

    Uniwersytet Jagielloński, Collegium Medicum

  33. The new homology model of H3 histaminic receptor - structure, interaction with ligand

    Call: PRELUDIUM 8 , Panel: NZ7

    Principal investigator: Jakub Jończyk

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  34. Synthesis of novel receptors, their application in chiral recognition of biologically relevant anions, and development o...

    Call: OPUS 8 , Panel: ST5

    Principal investigator: prof. Janusz Jurczak

    Instytut Chemii Organicznej PAN

  35. Role of glucocorticoids in the regulation of hematopoiesis in patients with abnormal secretion of steroid hormones: a no...

    Call: OPUS 1 , Panel: NZ5

    Principal investigator: dr Miłosz Kawa

    Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

  36. Binding isotope effects as new, unique tool for studies of receptor - ligand interactions

    Call: MAESTRO 1 , Panel: ST4

    Principal investigator: prof. Piotr Paneth

    POLITECHNIKA ŁÓDZKA

  37. Novel approach to the chiral recognition of organic cations and anions - dynamic combinatorial chemistry

    Call: MAESTRO 1 , Panel: ST5

    Principal investigator: prof. Janusz Jurczak

    Instytut Chemii Organicznej PAN

  38. Partial agonists of alpha-2 adrenoceptors as new perspective of the effective and safe in reducting body weight and obes...

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr Magdalena Dudek

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  39. Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Karolina Barbara Przepiórska-Drońska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  40. Integrated multi-omics approach to accelerate anticancer drug discovery by targeting metabolic reprogramming in human co...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr hab. Danuta Dudzik

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  41. Development of novel light-controllable azobenzene switches as molecular receptors for selective sensing and transport o...

    Call: SONATA 12 , Panel: ST5

    Principal investigator: dr Kajetan Dąbrowa

    Instytut Chemii Organicznej Polskiej Akademii Nauk

  42. Functional selectivity of novel histamine H4 receptor ligands

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Agnieszka Olejarz-Maciej

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  43. Evaluation of the anticancer efficacy of a new chimeric antigen receptor targeting PD-L1 molecule

    Call: OPUS 12 , Panel: NZ6

    Principal investigator: dr hab. Radosław Zagożdżon

    Warszawski Uniwersytet Medyczny, Wydział Lekarski

  44. Novel hybrid 5-HT6 serotonin receptor and SERT transporter ligands as a therapeutic perspective of behavioural and cogni...

    Call: SONATA 14 , Panel: NZ7

    Principal investigator: dr Agata Siwek

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  45. Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: dr hab. Marcin Marek Ratajewski

    Instytut Biologii Medycznej Polskiej Akademii Nauk

  46. The study of the role of mGluR8 in cancer cells - a potential target for new antitumor strategies

    Call: OPUS 3 , Panel: NZ3

    Principal investigator: dr Danuta Jantas

    Instytut Farmakologii PAN

  47. Obtaining of new quinoline derivatives with potential activity for serotonin receptors and inhibition of serotonin reupt...

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: Przemysław Taciak

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  48. A comparative evaluation of effectiveness of phosphorothioate and phosphodiester lysophosphatidylcholine analogues in re...

    Call: PRELUDIUM 6 , Panel: NZ5

    Principal investigator: Anna Drzazga

    Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

  49. Novel type modulators of purinergic receptors - Synthesis and study of receptor-ligand interaction

    Call: OPUS 7 , Panel: NZ1

    Principal investigator: prof. Zbigniew Leśnikowski

    Instytut Biologii Medycznej PAN

  50. Stearoyl-CoA desaturase and intracellular lipid signaling as novel players in regulation of thyroid hormone action in th...

    Call: OPUS 7 , Panel: NZ4

    Principal investigator: dr hab. Paweł Dobrzyń

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

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