Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Chronic pain in obesity: from cellular mechanisms to new strategies for targeted therapy.

2021/43/D/NZ5/02559

Keywords:

obesity chronic pain neuropathic pain hypersensitivity melanocortin system opioid system liver X receptors neuroinflammation

Descriptors:

  • NZ5_003:
  • NZ5_007:
  • NZ7_014:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Piotrowska-Murzyn 

Number of co-investigators in the project: 5

Call: SONATA 17 - announced on 2021-09-15

Amount awarded: 2 991 577 PLN

Project start date (Y-m-d): 2022-11-29

Project end date (Y-m-d): 2026-11-28

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. A Missing Puzzle in Preclinical Studies-Are CCR2, CCR5, and Their Ligands' Roles Similar in Obesity-Induced Hypersensitivity and Diabetic Neuropathy?-Evidence from Rodent Models and Clinical Studies
    Authors:
    Bober A., Mika J., Piotrowska A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25(20), strony: 11323), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252011323 - link to the publication
  2. A New Application for Cenicriviroc, a Dual CCR2/CCR5 Antagonist, in the Treatment of Painful Diabetic Neuropathy in a Mouse Model
    Authors:
    Bober A., Piotrowska A., Pawlik K., Ciapała K., Maciuszek M., Makuch W., Mika J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25(13), strony: 7410), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25137410 - link to the publication
  1. BLOCKAGE OF CCR2 AND CCR5 AS A POTENTIAL THERAPEUTIC TARGET FOR DIABETIC NEUROPATHIC PAIN
    Authors:
    Bober A., Piotrowska A., Bogacka J., Ciapała K., Pawlik K., Mika J.
    Conference:
    Acta Neurobiologiae Experimentalis (rok: 2024, tom: 3th Neuronus Neuroscience Forum 2024, strony: 4: I–CLXVIII), Wydawca: ANE
    Data:
    konferencja 2024-04-25-27
    Status:
    Published
  2. Ból przewlekły a otyłość: współzależność i mechanizmy predysponujące do ich występowania
    Authors:
    Piotrowska A., Maciuszek M., Bober A.
    Conference:
    Ból (rok: 2024, tom: IX Sympozjum Polskiego Towarzystwa Badania Bólu – Postępy w leczeniu bólu, strony: 49-50), Wydawca: Index Copernicus
    Data:
    konferencja 2024-10-17-19
    Status:
    Published
  3. Rola chemokin w rozwoju nadwrażliwości w mysim modelu cukrzycy i otyłości
    Authors:
    Maciuszek M., Bober A., Pawlik K., Ciapała K., Makuch W., Mika J., Piotrowska A.,
    Conference:
    Ból (rok: 2024, tom: IX Sympozjum Polskiego Towarzystwa Badania Bólu – Postępy w leczeniu bólu, strony: 57), Wydawca: Index Copernicus
    Data:
    konferencja 2024-10-17-19
    Status:
    Published