Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Maternal diet during gestation and nutrition as a risk factor for cocaine use disorder in offspring - preclinical behavioral and neurochemical studies on the role of brain melanocortin 4 receptors in rats.

2016/21/B/NZ4/00203

Keywords:

Cocaine self-administration extinction training and relapse forced swim test elevated zero-maze novel object recognition impulsive behavior palatable food intake high-fat diet high-sugar diet rats MC4 receptor ligands virus vectors intracranial injections BS3 crosslinking postsynaptic density Western Blot

Descriptors:

  • NZ4_12: Other related subjects
  • NZ5_9: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Filip 

Number of co-investigators in the project: 10

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 176 445 PLN

Project start date (Y-m-d): 2017-02-01

Project end date (Y-m-d): 2022-01-31

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Urządzenie do przeprowadzania reakcji PCR wraz z fluorymetrem.
  2. Wirówka PCR.
  3. stolik stereotaktyczny dla gryzoni (33 000 PLN)
  4. czytnik mikropłytek do pomiaru absorbancji (78 000 PLN)
  5. Bio Miernik PH (5 173 PLN)
  6. gilotyna dla małych zwierząt (gryzoni) (6 000 PLN)
  7. oświetlenie laboratoryjne ze światłowodami typu "goose neck" (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (13)
  1. Maternal high carbohydrate diet changes offspring vulnerability to reinstatement of cocaine-seeking behavior: role of melanocortin-4 receptors
    Authors:
    Gawliński D., Gawilńska K., Frankowska M., Filip M.
    Academic press:
    FASEB Journal (rok: 2020, tom: 34, strony: 9192-9206), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202000163R - link to the publication
  2. Maternal feeding patterns affect the offspring's brain: focus on serotonin 5-HT2C and 5-HT2A receptors
    Authors:
    Gawlińska K., Gawliński D., Filip M., Przegaliński E.
    Academic press:
    Pharmacological Reports (rok: 2021, tom: 73, strony: 1170-1178), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s43440-021-00298-0 - link to the publication
  3. Maternal dietary patterns are associated with susceptibility to a depressive-like phenotype in rat offspring.
    Authors:
    Gawlińska, K., Gawliński, D., Korostyński, M., Borczyk, M., Frankowska, M., Piechota, M., Filip, M., Przegaliński, E.
    Academic press:
    Developmental Cognitive Neuroscience (rok: 2021, tom: 47, strony: 100879), Wydawca: ELSEVIER SCI LTD
    Status:
    Published
    DOI:
    10.1016/j.dcn.2020.100879 - link to the publication
  4. MATERNAL HIGH-FAT DIET DURING PREGNANCY ANDLACTATION PROVOKES DEPRESSIVE-LIKE BEHAVIOR ANDINFLUENCES THEIRISIN/BRAIN-DERIVED NEUROTROPHIC FACTOR AXIS ANDINFLAMMATORY FACTORS INMALE ANDFEMALE OFFSPRING INRATS
    Authors:
    Gawlińska K., Gawliński D., Przegaliński D., Filip M.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2019, tom: 70 (3), strony: 407-411), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    0.26402/jpp.2019.3.07 - link to the publication
  5. Maternal Diet Influences the Reinstatement of Cocaine-Seeking Behavior and the Expression of Melanocortin-4 Receptors in Female Offspring of Rats.
    Authors:
    Gawliński, D., Gawlińska, K., Frankowska, M., Filip, M.
    Academic press:
    Nutrients (rok: 2020, tom: 12, strony: 1462), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12051462 - link to the publication
  6. Relationship between maternal high-fat diet during pregnancy and lactation and 1 offspring health.
    Authors:
    Gawlińska K., Gawliński D., Filip M., Przegaliński E.
    Academic press:
    Nutrition Reviews (rok: 2021, tom: 79, strony: 709-725), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nutrit/nuaa020 - link to the publication
  1. Modified maternal diet alters melanocortin-4 receptor levels in the brain of male rat offspring.
    Authors:
    Gawliński D., Mudlaff K., Filip M.
    Conference:
    31 ECNP Congress, The future of CNS treatments" 2018, Barcelona (rok: 2018, ), Wydawca: ECNP
    Data:
    konferencja 6-9.10
    Status:
    Published
  2. The effects of maternal diet on adaptive changes in the brain melanocortin 4 receptors in female offspring.
    Authors:
    Mudlaff K., Gawliński D., Filip M.
    Conference:
    31 ECNP Congress, The future of CNS treatments" 2018, Barcelona (rok: 2018, ), Wydawca: ECNP
    Data:
    konferencja 6-9.10
    Status:
    Published
  3. Effect of maternal carbohydrate diet on MC4 receptors in rat brain after cocaine self-administration.
    Authors:
    Gawliński D., Mudlaff K., Frankowska M., Wydra K., Filip M.
    Conference:
    3rd Central European Biomedical Congress News on biomarker discovery and research innovations in medicine and biomedical sciences" (rok: 2018, ), Wydawca: CEBC
    Data:
    konferencja 15-18.09
    Status:
    Published
  4. The effects of maternal high carbohydrates diet on melanocortin-4 receptor levels in the brain of male and female rat offspring.
    Authors:
    Mudlaff K., Gawliński D., Przegaliński E., Filip M.
    Conference:
    SfN 2018, San Diego (rok: 2018, ), Wydawca: SfN
    Data:
    konferencja 2-7.11.
    Status:
    Published
  5. Effects of m aternal high carbohydrate and fat diet in the novel object recognition test in female offspring rats
    Authors:
    Mudlaff K., Gawliński D., Kluska K., Filip M.
    Conference:
    6th International Conference Aspects of Neuroscience, Warszawa (rok: 2017, ), Wydawca: Published by Faculty of Biology University of Warsaw, ISBN 978-83-942342-6-3, Warszawa
    Data:
    konferencja 24-26 listopada
    Status:
    Published
  6. Maternal high carbohydrate diet enhances cocaine seeking behaviour in male rat offspring.
    Authors:
    Gawliński D., Frankowska M., Kluska K., Filip M.
    Conference:
    Neurobiology of Obesity Symposium, Aberdeen (rok: 2017, ), Wydawca: NOS
    Data:
    konferencja 16-17 września
    Status:
    Published
  7. Effects of cocaine self-administration on melanocortin-4 receptors in selected rat brain structures.
    Authors:
    Gawliński D., Mudlaff K., Frankowska M., Wydra K., Filip M.
    Conference:
    SfN 2018 San Diego (rok: 2018, ), Wydawca: SfN
    Data:
    konferencja 2-7.11
    Status:
    Published
  8. Maternal high fat diet provokes depressive-like behavior in offspring rats and vulnerability to cocaine addiction
    Authors:
    Gawliński D., Frankowska M., Kluska K., Filip M.
    Conference:
    13th International Congress of Polish Neuroscience Society, Warszawa, 28-31 września 2017 (rok: 2017, ), Wydawca: Acta Neurobiol Exp 2017, 77: I–CXLII
    Data:
    konferencja 28-31 września
    Status:
    Published
  9. Changes of 5-HT 2C receptors in female offspring brain after maternal exposition to modified diet
    Authors:
    Mudlaff K., Gawliński D., Filip M., Przegaliński E.
    Conference:
    20th International Congress of the Polish Pharmacological Society (rok: 2019, ), Wydawca: Polish Pharmacological Society
    Data:
    konferencja 43621
    Status:
    Published
  10. Effect of maternal high fat diet on anxiety-like behavior in male and female rats in early adolescence period
    Authors:
    Gawliński D., Frankowska M., Mudlaff K., Filip M.
    Conference:
    6th International Conference Aspects of Neuroscience, Warszawa (rok: 2017, ), Wydawca: Published by Faculty of Biology University of Warsaw, ISBN 978-83-942342-6-3, Warszawa
    Data:
    konferencja 24-26 listopada
    Status:
    Published
  11. Effect of maternal high fat or high carbohydrate diet on the expression of 5-HT 2C receptors in rat male offspring brain
    Authors:
    Gawliński D., Mudlaff K., Filip M.
    Conference:
    20th International Congress of the Polish Pharmacological Society (rok: 2019, ), Wydawca: Polish Pharmacological Society
    Data:
    konferencja 43621
    Status:
    Published
  12. Effect of maternal western diet" in the novel object recognition test in female and male offspring rats.
    Authors:
    Mudlaff K., Gawliński D., Filip M.
    Conference:
    2018 IBRO & IRUN Neuroscience Forum, 2018 Krakow (rok: 2018, ), Wydawca: IBRO & IRUN
    Data:
    konferencja 20-22.04
    Status:
    Published
  13. The effect of maternal modified diet on anxiety-like behavior in adolescent male and female rats.
    Authors:
    Gawliński D., Mudlaff K., Filip M.
    Conference:
    NEURONUS 2018 IBRO & IRUN Neuroscience Forum, Krakow (rok: 2018, ), Wydawca: IBRO & IRUN
    Data:
    konferencja 20-22.04
    Status:
    Published

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