Projects funded by the NCN

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98 projects found matching your search criteria :

  1. Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Andrzej Pilc

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  2. Dual histamine H3 and sigma-1 receptor ligands as novel pharmacological tools in the treatment of central nervous system...

    Call: SONATINA 4 , Panel: NZ7

    Principal investigator: Katarzyna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  3. Investigation of novel functionally selective opioid receptors agonists

    Call: ETIUDA 8 , Panel: NZ7

    Principal investigator: Łucja Kudła

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  4. Chasing the HARE: elucidation of the binding mechanism of the new and unexplored ligandsof the Hyaluronic Acid Receptor ...

    Call: SONATINA 4 , Panel: NZ1

    Principal investigator: dr Aleksandra Twarda-Cłapa

    Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

  5. Novel role of peroxisome proliferator-activated receptor α in the regulationof amyloid β peptide metabolism and mitochon...

    Call: PRELUDIUM 18 , Panel: NZ4

    Principal investigator: Sylwia Wójtowicz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  6. Pharmacological modulation of histamine H3 and H4 receptors - a new perspective in the treatment of neuropathic pain

    Call: SONATA 15 , Panel: NZ7

    Principal investigator: dr Katarzyna Popiołek-Barczyk

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  7. Novel approach to the chiral recognition of organic cations and anions - dynamic combinatorial chemistry

    Call: MAESTRO 1 , Panel: ST5

    Principal investigator: prof. Janusz Jurczak

    Instytut Chemii Organicznej PAN

  8. Binding isotope effects as new, unique tool for studies of receptor - ligand interactions

    Call: MAESTRO 1 , Panel: ST4

    Principal investigator: prof. Piotr Paneth

    POLITECHNIKA ŁÓDZKA

  9. Specific interactions of new antitumor unsymmetrical bisacridines, UAs, with DNA and ABC proteins and their potential to...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: prof. Zofia Mazerska

    Politechnika Gdańska

  10. Neuroprotective properties of 5-HT6 receptor ligands in the group of 2-arylpyrrole derivatives – a new insight into neur...

    Call: PRELUDIUM 17 , Panel: NZ7

    Principal investigator: Marcin Drop

    Uniwersytet Jagielloński, Collegium Medicum

  11. Effects of a novel nonaddictive opioid on response to stress

    Call: PRELUDIUM 17 , Panel: NZ7

    Principal investigator: Łucja Kudła

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  12. Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: dr hab. Marcin Ratajewski

    Instytut Biologii Medycznej Polskiej Akademii Nauk

  13. Anticancer Trojan horses: Application of the bioconjugation idea to invent new anticancer drugs

    Call: UWERTURA 3 , Panel: ST4

    Principal investigator: dr Michał Antoszczak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  14. New calcitriol analogues with unnatural D ring

    Call: PRELUDIUM 16 , Panel: ST5

    Principal investigator: Adrian Fabisiak

    Uniwersytet Warszawski, Wydział Chemii

  15. Searching for effective strategies to protect neuronal cells against hypoxia and ischemia: Identification of neuroprotec...

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kajta

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  16. Prognostic value of platelet-derived microRNAs in patients with acute coronary syndrome treated with novel P2Y12 recepto...

    Call: PRELUDIUM 16 , Panel: NZ7

    Principal investigator: dr hab. Aleksandra Gąsecka-van der Pol

    Warszawski Uniwersytet Medyczny, I Wydział Lekarski

  17. Role of glucocorticoids in the regulation of hematopoiesis in patients with abnormal secretion of steroid hormones: a no...

    Call: OPUS 1 , Panel: NZ5

    Principal investigator: dr Miłosz Kawa

    Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

  18. Novel hybrid 5-HT6 serotonin receptor and SERT transporter ligands as a therapeutic perspective of behavioural and cogni...

    Call: SONATA 14 , Panel: NZ7

    Principal investigator: dr Agata Siwek

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  19. Evaluation of therapeutic role of novel positive allosteric modulators of GABA-A receptor in ischemic brain stroke

    Call: SONATA BIS 8 , Panel: NZ7

    Principal investigator: dr Monika Marcinkowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  20. Molecular characterisation of novel mutations in the gene encoding the luteinizing hormone/choriogonadotropin receptor (...

    Call: PRELUDIUM 15 , Panel: NZ5

    Principal investigator: Kamila Adamczuk

    Uniwersytet Medyczny w Lublinie, Wydział Lekarski

  21. Characterization of genetic determinants of the mannose-specific phosphotransferase system (Man-PTS) determining sensiti...

    Call: PRELUDIUM 15 , Panel: NZ1

    Principal investigator: Aleksandra Tymoszewska

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  22. New strategies in neuropathic pain pharmacotherapy based on the modulation of the functions of chemokine receptors CCR2 ...

    Call: PRELUDIUM 15 , Panel: NZ7

    Principal investigator: dr Klaudia Kwiatkowski

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  23. Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: prof. Barbara Przewłocka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  24. New derivatives of clopidogrel - enantioselective biosynthesis and antiplatelet activity in vitro

    Call: PRELUDIUM 14 , Panel: NZ7

    Principal investigator: Adam Sikora

    Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

  25. Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  26. New vanilloid type 1 receptor (TRPV1) antagonists in the search for substances with wide-spectrum of anticonvulsant and ...

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Krzysztof Kamiński

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  27. STIM proteins as new regulators of NMDA receptor trafficking in neurons

    Call: SONATA BIS 7 , Panel: NZ3

    Principal investigator: dr Joanna Gruszczyńska-Biegała

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  28. New receptors for C-reactive protein recognition - generation, characterization and application towards fast differentia...

    Call: SONATA 13 , Panel: ST5

    Principal investigator: dr Katarzyna Szot-Karpińska

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  29. Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic st...

    Call: HARMONIA 9 , Panel: NZ7

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  30. Intracellular cross-talk between ligands and Notch receptors determine signalling response

    Call: OPUS 13 , Panel: NZ4

    Principal investigator: prof. Adolfo Rivero-Muller

    Uniwersytet Medyczny w Lublinie, Wydział Lekarski

  31. Novel ligands of histamine receptor H4 as potential anti-allergic and anti-inflammatory drugs

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Sławomir Filipek

    Uniwersytet Warszawski, Wydział Chemii

  32. Evaluation of the anticancer efficacy of a new chimeric antigen receptor targeting PD-L1 molecule

    Call: OPUS 12 , Panel: NZ6

    Principal investigator: dr hab. Radosław Zagożdżon

    Warszawski Uniwersytet Medyczny, Wydział Lekarski

  33. Evaluation of relationship between markers of Epstein-Barr virus infection and selected immune parameters in patients wi...

    Call: OPUS 12 , Panel: NZ6

    Principal investigator: prof. Wojciech Załuska

    Uniwersytet Medyczny w Lublinie, Wydział Lekarski

  34. NK cells with inducible expression of CAR as novel immunotherapy increasing the efficacy of monoclonal antibodies.

    Call: OPUS 12 , Panel: NZ5

    Principal investigator: dr Beata Pyrzyńska

    Warszawski Uniwersytet Medyczny, I Wydział Lekarski

  35. Analysis and evaluation of the effectiveness of anorexic and safety properties for the new histamine H3 receptor ligands

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Magdalena Kotańska

    Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  36. New perspective in Alzheimer's disease therapy - multifunctional histamine H3 receptor ligands?

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Dorota Łażewska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  37. Functional selectivity of novel histamine H4 receptor ligands

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Agnieszka Olejarz-Maciej

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  38. New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searc...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Michał Załuski

    Uniwersytet Jagielloński, Collegium Medicum, Wydział Farmaceutyczny

  39. Development of novel light-controllable azobenzene switches as molecular receptors for selective sensing and transport o...

    Call: SONATA 12 , Panel: ST5

    Principal investigator: dr Kajetan Dąbrowa

    Instytut Chemii Organicznej Polskiej Akademii Nauk

  40. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Anna Więckowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  41. Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Paweł Zajdel

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  42. Maternal diet during gestation and nutrition as a risk factor for cocaine use disorder in offspring - preclinical behavi...

    Call: OPUS 11 , Panel: NZ4

    Principal investigator: prof. Małgorzata Filip

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  43. Search for the functionally selective 5-HT1A receptor agonists as new pharmacological tools in the development of treatm...

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: prof. Marcin Kołaczkowski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  44. Searching for the new lead structures for 5-HT7 serotonin receptor ligands with increased metabolic stability.

    Call: HARMONIA 7 , Panel: NZ7

    Principal investigator: Sabina Podlewska

    Instytut Farmakologii PAN

  45. Synthesis and binding studies of new podands based on 1,8-diaminocarbazole moiety

    Call: PRELUDIUM 9 , Panel: ST5

    Principal investigator: Krzysztof Bąk

    Uniwersytet Warszawski, Wydział Chemii

  46. Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

    Call: OPUS 9 , Panel: ST5

    Principal investigator: prof. Maria Bretner

    Politechnika Warszawska, Wydział Chemiczny

  47. Traizine 5-HT6 receptor ligands - new perspective for therapy of current civilization CNS-diseases

    Call: OPUS 9 , Panel: NZ7

    Principal investigator: dr hab. Jadwiga Handzlik

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  48. Porphyromonas gingivalis protein and its homologs from other periodontopathogens - a novel group of bacterial virulence ...

    Call: OPUS 9 , Panel: NZ6

    Principal investigator: prof. Teresa Olczak

    Uniwersytet Wrocławski, Wydział Biotechnologii

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