Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Novel hybrid 5-HT6 serotonin receptor and SERT transporter ligands as a therapeutic perspective of behavioural and cognitive disorders in Alzheimer's disease.

2018/31/D/NZ7/01433

Keywords:

depression dementia Alzheimer's disease multitarget ligands

Descriptors:

  • NZ7_14:
  • ST5_16:
  • ST5_23:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agata Siwek 

Number of co-investigators in the project: 6

Call: SONATA 14 - announced on 2018-09-14

Amount awarded: 870 500 PLN

Project start date (Y-m-d): 2019-07-11

Project end date (Y-m-d): 2024-07-10

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. Dual molecules targeting 5-HT6 and GABA-A receptors as a new approach to combat depression associated with neuroinflammation
    Authors:
    Monika Marcinkowska, Barbara Mordyl, Agata Siwek, Monika Głuch-Lutwin, Tadeusz Karcz, Alicja Gawalska,, Michał Sapa, Adam Bucki, Katarzyna Szafrańska, Bartosz Pomierny, Karolina Pytka, Magdalena Kotańska, Kamil Mika, Marcin Kolaczkowski
    Academic press:
    ACS Chemical Neurosciene (rok: 2023, tom: 14, strony: 1474-1489), Wydawca: ACS Publishing
    Status:
    Published
    DOI:
    10.1021/acschemneuro.3c00033 - link to the publication
  2. Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties
    Authors:
    Agata Siwek, Monika Marcinkowska, Monika Głuch-Lutwin, Barbara Mordyl, Małgorzata Wolak, Magdalena Jastrzębska-Więsek, Natalia Wilczyńska-Zawal, Elżbieta Wyska, Katarzyna Szafrańska, Tadeusz Karcz, Olga Ostrowska, Adam Bucki, Marcin Kołaczkowski
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2024, tom: 275, strony: 116601), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2024.116601 - link to the publication
  1. INVESTIGATION OF THE MOLECULAR MECHANISM OF ANTIDEPRESSANT‑LIKE ACTION OF KETAMINE AND 5‑HT6 RECEPTOR AGONIST (ST1936) IN MALE RAT CEREBELLUM
    Authors:
    Bartosz Babik, Alicja Radzimska, Aleksandra Smoleń, Wiktoria Sajdok, Małgorzata Wolak Agata Siwek
    Conference:
    Neuronus 2022, IBRO Neuroscience Forum (rok: 2022, ), Wydawca: NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY PAS WARSAW, POLAND
    Data:
    konferencja 15-17.10.2022 r.
    Status:
    Published

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