Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Novel ligands of histamine receptor H4 as potential anti-allergic and anti-inflammatory drugs

2017/25/B/NZ7/02788

Keywords:

GPCRs histamine receptors allergy inflammation anti-inflammatory drugs

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST6_13: Bioinformatics, biocomputing, DNA and molecular computation

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Sławomir Filipek 

Number of co-investigators in the project: 8

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 707 400 PLN

Project start date (Y-m-d): 2018-02-16

Project end date (Y-m-d): 2022-02-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dodatkowa stacja robocza (69 445 PLN)
  2. GraphPad Prism (2 szt.) (7 200 PLN)
  3. Mikroskop badawczy (4 000 PLN)
  4. Platforma programowa OpenEye (50 000 PLN)
  5. Wirówka laboratoryjna (10 000 PLN)
  6. program ICM-Pro (3 szt.) (36 000 PLN)
  7. Dewar na ciekły azot (6 000 PLN)
  8. Program YASARA (4 384 PLN)
  9. pompa próżniowa rotacyjna olejowa (2 szt.) (18 000 PLN)
  10. Chemdraw 16 (2 szt.) (12 000 PLN)
  11. Lampa UV.
  12. Pakiet programów AxPyMOL/PyMOL (1 979 PLN)
  13. Program AMBER20 (2 442 PLN)
  14. Program LigandScout (15 000 PLN)
  15. Suszarka próżniowa (20 000 PLN)
  16. stacja robocza (2 szt.) (90 000 PLN)
  17. Platforma programowa Schrodinger.
  18. Jonizator elektrostatyczny (4 043 PLN)
  19. Membranowa pompa próżniowa.
  20. Waga precyzyjna (2 441 PLN)
  21. Wyparka próżniowa z wyposażeniem.
  22. Łaźnia wodna (4 269 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  • Book publications / chapters in book publications (2)
  1. Enigmatic histamine receptor H4 for potential treatment of multiple inflammatory, autoimmune and related diseases
    Authors:
    P. Mehta, P. Miszta, P. Rzodkiewicz, O. Michalak, P. Krzeczyński, S. Filipek
    Academic press:
    Life (rok: 2020, tom: 10, strony: 50), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/life10040050 - link to the publication
  2. Molecular Modeling of Histamine Receptors – Recent Advances in Drug Discovery
    Authors:
    P. Mehta, P. Miszta, S. Filipek
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 1778), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26061778 - link to the publication
  3. Molecular switches in GPCRs
    Authors:
    S. Filipek
    Academic press:
    Current Opinion in Structural Biology (rok: 2019, tom: 55, strony: 114–120), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.sbi.2019.03.017 - link to the publication
  4. GPCRmd uncovers the dynamics of the 3D-GPCRome
    Authors:
    I. Rodríguez-Espigares, M. Torrens-Fontanals, J.K.S. Tiemann, D. Aranda-García, J.M. Ramírez-Anguita, T.M. Stepniewski, N. Worp, A. Varela-Rial, A. Morales-Pastor, B.M. Lacruz, G. Pándy-Szekeres, E. Mayol, R. Fonseca, T. Giorgino, J. Carlsson, X. Deupi, S. Filipek, J.C. Gómez-Tamayo, A. Gonzalez, H. Gutierrez-de-Teran, M. Jimenez, W. Jespers, J. Kapla, P. Kolb, D. Latek, M. Marti-Solano, P. Matricon, M.T. Matsoukas, P. Miszta, M. Olivella, L. Perez-Benito, S. Ríos, I. Rodríguez-Torrecillas, J. Sallander, A. Sztyler, S. Vasile, P.W. Hildebrand, G. De Fabritiis, D.E. Gloriam, A. Cordomi, R. Guixà-González, J. Selent
    Academic press:
    Nature Methods (rok: 2020, tom: 17, strony: 777-787), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41592-020-0884-y - link to the publication
  5. GPCRsignal: webserver for analysis of the interface between G-protein–coupled receptors and their effector proteins by dynamics and mutations
    Authors:
    P. Miszta, P. Pasznik, S. Niewieczerzał, J. Jakowiecki, S. Filipek
    Academic press:
    Nucleic Acids Research (rok: 2021, tom: 49, strony: W247-W256), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkab434 - link to the publication
  6. Unexpected Reaction Products of Uracil and Its Methyl Derivatives with Acetic Anhydride and Methylene Chloride
    Authors:
    O. Michalak, P. Cmoch, A. Leś, M. Cybulski, P. Krzeczyński, K. Trzcińska, P. Miszta, P. Mehta, S. Filipek
    Academic press:
    Journal of Organic Chemistry (rok: 2021, tom: 86, strony: 14321-14332), Wydawca: The American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.joc.1c00748 - link to the publication
  1. Virtual screening of ligands of histamine H3 and H4 receptors
    Authors:
    P. Mehta, O. Michalak, P. Rzodkiewicz, S. Filipek
    Conference:
    48th Annual Meeting of The European Histamine Research Society (rok: 2019, ), Wydawca: Springer
    Data:
    konferencja 2019-05-15-18
    Status:
    Published
  1. Homology Modeling Using GPCRM Web Service
    Authors:
    P. Miszta, S. Niewieczerzał, P. Pasznik, S. Filipek
    Book:
    G Protein-Coupled Receptor Screening Assays. Methods and Protocols (rok: 2021, tom: 2268, strony: 305-321), Wydawca: Springer Science+Business Media
    Status:
    Published
  2. Structural Diversity in Ligand Recognition by GPCRs
    Authors:
    J. Jakowiecki, P. Miszta, S. Niewieczerzał, S. Filipek
    Book:
    GPCRs: Structure, Function, and Drug Discovery (rok: 2020, tom: --, strony: 43-63), Wydawca: Elsevier Academic Press
    Status:
    Published

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