Projects funded by the NCN

Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

Call: OPUS 23 , Panel: NZ5

Principal investigator: dr hab. Urszula Mackiewicz

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Chemical and surgical castration of sex offenders - effective punishment, therapeutic measure or dehumanizing torture? A...

Call: PRELUDIUM 21 , Panel: HS5

Principal investigator: Katarzyna Teresa Jakubczak-Fopke

Uniwersytet Gdański, Wydział Prawa i Administracji

Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Karolina Barbara Przepiórska-Drońska

Instytut Farmakologii PAN

The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Magdalena Białoń

Instytut Farmakologii PAN

Targeting of metabolic and transcriptomic cross-talk between leukemic cells and macrophages as a therapeutic strategy in...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Monika Chomczyk

Instytut Hematologii i Transfuzjologii

Mechanisms and consequences of CD19 loss in B-acute lymphoblastic leukaemia patients relapsing after CD19-CAR-T cell the...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Targeting UDP-glucose and P2Y14 receptor interaction for therapeutic modulation of inflammatory lung diseases

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Tadeusz Piotr Karcz

Uniwersytet Jagielloński, Collegium Medicum

Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Maciej Stefan Szydłowski

Instytut Hematologii i Transfuzjologii

Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Kamil Przyborowski

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Targeting of HSF1 as a therapeutic approach to inhibit the progression of hormone-dependent breast cancer.

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Natalia Vydra

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

New immunomodulators of BTLA-HVEM complex as potential therapeutics in systemic lupus erythematosus

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Anna Wardowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Identification and therapeutic targeting of the mRNA splicing alteration mechanisms driven by gain-of-function TP53 muta...

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Magdalena Oroń

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Searching for new therapeutic targets in polyglutamine diseases

Call: OPUS 22 , Panel: NZ2

Principal investigator: prof. Marta Olejniczak

Instytut Chemii Bioorganicznej PAN

P-stereodefined phosphorothioate analogs of morpholino" oligonucleotides (sTMO) as a new model of therapeutic nucleic ac...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Katarzyna Jastrzębska

Centrum Badań Molekularnych i Makromolekularnych PAN

Non-provitamin A carotenoids as a novel therapeutic strategy in intestinal failure associated liver disease (IFALD)

Call: PRELUDIUM BIS 3 , Panel: NZ7

Principal investigator: dr hab. Maciej Jan Stawny

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

efFect of nanoscale, three dimensIonal arrangement of proteins on biological and Therapeutic activity (FIT)

Call: OPUS 22 (LAP) , Panel: NZ1

Principal investigator: dr Antonina Naskalska

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

The roles and therapeutic potential of distinct dystrophin and utrophin isoforms in the central and peripheral nervous s...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Patryk Konieczny

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Proline metabolism as a novel therapeutic target for diseases associated with mitochondrial dysfunction.

Call: SONATA BIS 11 , Panel: NZ3

Principal investigator: dr Karolina Szczepanowska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Anna Agnieszka Marusiak

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Role of Mcpip1 in biliary pathobiology: new potential therapeutic opportunities

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Jerzy Kotlinowski

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Improvement of therapeutic safety of parenteral nutrition in cancer patients - the interplay between supportive drugs an...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Szymon Tomczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

New type of analogs and conjugates of folic acid with potential therapeutic applicaton in treatment of hormone-dependent...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Olga Ciupak

Politechnika Gdańska, Wydział Chemiczny

Assessment of SARS-CoV-2 infection in patients with chronic lymphocytic leukemia depending on indicators of immune disor...

Call: OPUS 21 , Panel: NZ6

Principal investigator: prof. Ewelina Pia Grywalska

Uniwersytet Medyczny w Lublinie

Effect of SSR 504734, a selective glycine transporter type 1 inhibitor, on seizure activity and therapeutic efficacy of ...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Piotr Wiktor Wlaź

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Investigation of a new therapeutic strategy to lower mutant protein in SCA3 / MJD

Call: OPUS 21 , Panel: NZ2

Principal investigator: prof. Maciej Figiel

Instytut Chemii Bioorganicznej PAN

Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Psychedelics as Therapeutic Candidates in Neurodegenerative Disorders Treatment– a Study in Spinocerebellar Ataxia Type ...

Call: SONATINA 5 , Panel: NZ4

Principal investigator: dr Urszula Joanna Kozłowska

Instytut Chemii Bioorganicznej PAN

Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

Call: SONATINA 5 , Panel: ST4

Principal investigator: dr Magdalena Zofia Wiloch-Szyborska

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Małgorzata Kajta

Instytut Farmakologii PAN

Development of tools for the rational design of peptide therapeutics

Call: OPUS 20 , Panel: NZ2

Principal investigator: prof. Sebastian Kmiecik

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

Polymersomes specifically releasing cGAMP and doxorubicin in tumor hypoxic regions as a new anti-cancer therapeutic stra...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr hab. Ryszard Smolarczyk

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Mechanism of splicing of MBNL1 transcript and its implications for potential therapeutic strategies for myotonic dystrop...

Call: SONATA 16 , Panel: NZ3

Principal investigator: dr Katarzyna Magdalena Taylor

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Vitreous Optical Tomography for objective diagnosis, monitoring and outcome measures of therapeutic interventions for vi...

Call: SONATA 16 , Panel: NZ5

Principal investigator: dr Daniel Rumiński

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Toxic RNA with expanded trinucleotide repeats: pathomechanism and therapeutic targets of neurological diseases

Call: MAESTRO 12 , Panel: NZ3

Principal investigator: prof. Krzysztof Sobczak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Modulation of immune cells activity in the tumor microenvironment by oligonucleotide therapeutics delivered by silk nano...

Call: OPUS 19 , Panel: NZ6

Principal investigator: prof. Hanna Dams-Kozłowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Immunogenicity of plant-produced chimeric Virus-Like Particles formed byHBcAg displaying HBsAg epitopes for potential th...

Call: POLS , Panel: NZ7

Principal investigator: dr Benita Ortega Berlanga

Instytut Genetyki Roślin PAN

The significance of circadian rhythm in urinary bladder cancer: deregulation of circadian genes as a putative therapeuti...

Call: OPUS 19 , Panel: NZ5

Principal investigator: prof. Edyta Wiesława Reszka

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Therapeutic activation and signalling determinants of the autoregulatory MBNL1 expression in myotonic dystrophy.

Call: OPUS 19 , Panel: NZ5

Principal investigator: dr Ewa Agnieszka Stępniak-Konieczna

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

Screening for new therapeutic targets in inherited retinal diseases based on protein-protein interactions analysis

Call: POLS , Panel: NZ4

Principal investigator: dr Xiaonan Liu

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej PAN

Understanding of the mesenchymal stem cells (MSCs)-mediated immune suppression mechanism in the neutrophilic experimenta...

Call: PRELUDIUM 19 , Panel: NZ5

Principal investigator: dr Marlena Tynecka

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

Assessment of therapeutic value and usefulness of new generation antibiotics and their metabolites as resistance markers...

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: Katarzyna Joanna Pauter-Iwicka

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Antisense oligonucleotides and their nanostructures conjugated with boron clusters; physico-chemical and biological char...

Call: ETIUDA 8 , Panel: ST4

Principal investigator: Damian Mateusz Kaniowski

Centrum Badań Molekularnych i Makromolekularnych PAN

Improving the healing potential of therapeutic proteins by planned, specific modifiactions on the example of bacteriolyt...

Call: PRELUDIUM 18 , Panel: NZ6

Principal investigator: Marek Harhala

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Dynamina-2 jako potencjalny cel terapeutyczny w chłoniaku rozlanym z dużych komórek B

Call: SONATA 15 , Panel: NZ5

Principal investigator: dr Patryk Górniak

Instytut Hematologii i Transfuzjologii

Improving therapeutic efficacy of anti-CD20 antibodies in precursor B-cell acute lymphoblastic leukemia

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr Małgorzata Firczuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The influence of EGFRvIII structure and its cellular distribution heterogeneity on designing new therapeutic and diagnos...

Call: OPUS 18 , Panel: NZ3

Principal investigator: prof. Piotr Rieske

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

Instytut Farmakologii PAN

Exploring influence of inorganic cell microenvironment on NO signalling deregulation in age-related disorders. From mole...

Call: OPUS 18 , Panel: ST4

Principal investigator: prof. Grażyna Jolanta Stochel

Uniwersytet Jagielloński, Wydział Chemii