Projects funded by the NCN

New nucleotide analogs containing triazole within oligophosphate bridge as mimics of the 5' end of mRNA - synthesis, pro...

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Sylwia Ciechanowicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Studies on the synthesis of newly discovered cyclic N6-threonylcarbamoyladenosine (ct6A) and its analogues and on the in...

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Michał Matuszewski

Politechnika Łódzka, Wydział Chemiczny

Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Marcin Ziemniak

Uniwersytet Warszawski, Wydział Fizyki

Biosynthesis of seleno-modified nucleosides in the anticodon loop of transfer ribonucleic acids. Evaluation of the enzym...

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Barbara Nawrot

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Synthesis, biological and biophysical evaluation of mRNA cap-peptide conjugates for targeted delivery of cap analogues t...

Call: OPUS 6 , Panel: ST5

Principal investigator: dr hab. Marzena Jankowska-Anyszka

Uniwersytet Warszawski, Wydział Chemii

Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

Call: SONATA BIS 3 , Panel: NZ1

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Transformation of 5'-O-monothiophosphate nucleoside to 5'-O-monophosphate in the cell - possible metabolism of phosphoro...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr Agnieszka Krakowiak

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Synthesis and study of spectroscopic and bilogical properties of nucleosides modyfied by new stilbene derivatives

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Przemysław Szczeciński

Politechnika Warszawska, Wydział Chemiczny

Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Marcin Chmielewski

Instytut Chemii Bioorganicznej PAN

New 3,8-disubstituted purine nucleoside analogues as prospective application for research of structure and biological ac...

Call: SONATA 3 , Panel: ST5

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

Influence of nucleotide sequence on the yield of radio- and photodamage to double stranded DNA fragments labelled with t...

Call: OPUS 3 , Panel: ST5

Principal investigator: prof. Janusz Rak

Uniwersytet Gdański, Wydział Chemii

Adenosine 5'-phosphoramidate as a novel signaling molecule; Study of enzymatic synthesis of this nucleotide and analysis...

Call: OPUS 3 , Panel: NZ1

Principal investigator: prof. Andrzej Guranowski

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

New reagents and methods in synthesis of modified nucleotides and their application for preparation biochemical tools an...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Conjugates of cap analogs with nanomaterials and biomolecules with potential applications in pharmacology or diagnostics

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Stereodefined phosphorothioate analogs of DNA with incorporated LNA-type nucleosides - synthesis and properties of compl...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Guga

Centrum Badań Molekularnych i Makromolekularnych PAN

Modified (oligo)nucleotides for photo-controlled manipulation of mRNA

Call: SONATA 18 , Panel: ST4

Principal investigator: dr Marcin Warmiński

Uniwersytet Warszawski, Wydział Fizyki

Synthesis and structural/biophysical studies of model mRNA/mt-tRNA oligomers to evaluate the role of modified nucleoside...

Call: OPUS 22 , Panel: ST4

Principal investigator: dr hab. Grażyna Leszczyńska

Politechnika Łódzka

mRNA 5' end methylation status: towards deeper understanding of biological role and identification of synthetic mimics

Call: OPUS 17 , Panel: ST4

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Exploring second generation of nucleotide analogues containing phosphoranesulfen- or phosphoraneselenamides as new struc...

Call: PRELUDIUM 16 , Panel: ST5

Principal investigator: dr Justyna Gołębiewska

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Synthesis and characterization of new molecular probes for monitoring activity of enzymes associated with RNA decapping ...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

The role of extracellular ATP fraction in induction of epithelial-mesenchymal transition - studies using analogs of nucl...

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Róża Pawłowska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Synthesis of trimethyl cap analogs modified with molecular rotors and their application in nuclear transport studies

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Błażej Wojtczak

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered...

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Elżbieta Sochacka

Politechnika Łódzka, Wydział Chemiczny

N-Oxide phosphobetaines in new synthetic strategies for P-modified phosphates and polyphospates of natural biomolecules ...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Magdalena Materna

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Purine salvage pathway enzymes as a target for pathogenic organisma lacking de novo purine synthesis -cas study of Helic...

Call: HARMONIA 7 , Panel: NZ1

Principal investigator: prof. Maria Bzowska

Uniwersytet Warszawski, Wydział Fizyki

Synthesis and evaluation of a novel toolkit for biology and biotechnology based on adenine nucleotides analogs

Call: SONATA BIS 5 , Panel: ST5

Principal investigator: dr hab. Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Jacek Stawiński

Instytut Chemii Bioorganicznej PAN