Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

2011/01/B/ST5/06414

Keywords:

organic synthesis nucleoside analogues nucleotide analogues pronucletides anti-HIV anti-HIV prodrugs HIV

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Stawiński 

Number of co-investigators in the project: 13

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 533 000 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2015-11-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mieszadła magnetyczne z grzaniem (2 szt.) (4 000 PLN)
  2. Pipety automatyczne (6 szt.) (5 000 PLN)
  3. Zestaw komputerowy (5 000 PLN)
  4. Kolumny HPLC guard (6 szt.) (4 000 PLN)
  5. Kolumny chromatograficzne (3 szt.) (12 000 PLN)
  6. Lampa UV z filtrami i obudowa (1 100 PLN)
  7. Miernik laboratoryjny (2 000 PLN)
  8. Pompa próżniowa membranowa z kontrolerem próżni (20 000 PLN)
  9. Termomikser z blokiem grzewczym (4 500 PLN)
  10. Czasze grzejne 1000 ml (3 szt.) (3 200 PLN)
  11. Kontroler prozni (3 500 PLN)
  12. Wagi analityczne (2 szt.) (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Novel reactivity of Fhit proteins: catalysts for fluorolysis of nucleoside 5'-phosphoramidates and nucleoside 5'--phosphosulfates to generate nucleoside 5'-phosphorofluoridates
    Authors:
    Anna M. Wojdyła-Mamon, Jarosław Zimny, Joanna Romanowska, Adam Kraszewski, Jacek Stawinski, Paweł Bieganowski and Andrzej Guranowski*
    Academic press:
    Biochemical Journal (rok: 2015, tom: 468, strony: 337-344), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BJ20141568 - link to the publication
  2. ArylH-Phosphonates 18. Synthesis, properties, and biological activity of 2',3' -dideoxynucleoside (N-heteroaryl)phosphoramidates of increased lipophilicity
    Authors:
    Krystian Kolodziej, Joanna Romanowska, Jacek Stawinski, Jerzy Boryski, Aleksandra Dabrowska, Andrzej Lipniacki, Andrzej Piasek , Adam Kraszewski , Michal Sobkowski, *
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2015, tom: 100, strony: 77-88), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2015.06.004 - link to the publication
  3. The case of triethylammonium cation loss during purification of certain nucleotide analogues: a cautionary note
    Authors:
    Krystian Kolodziej, Joanna Romanowska, Jacek Stawinski, Adam Kraszewski & Michal Sobkowski
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2015, tom: 407, strony: 1775-1780), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-014-8397-0 - link to the publication
  4. Recent Advances inH-Phosphonate Chemistry. Part 1.H-Phosphonate Esters: Synthesis and Basic Reactions
    Authors:
    Michal Sobkowski, Adam Kraszewski, and Jacek Stawinski
    Academic press:
    Topics in Current Chemistry (rok: 2015, tom: 361, strony: 137-178), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/128_2014_562 - link to the publication
  5. Recent Advances inH-Phosphonate Chemistry. Part 2. Synthesis of C-Phosphonate Derivatives
    Authors:
    Michal Sobkowski, Adam Kraszewski, and Jacek Stawinski
    Academic press:
    Topics in Current Chemistry (rok: 2015, tom: 361, strony: 179-216), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/128_2014_563 - link to the publication
  6. Nucleoside 3',5' -Cyclic H ‑ Phosphonates, New Useful Precursors for the Synthesis of Nucleoside 3',5' -Cyclic Phosphates and Their Analogues
    Authors:
    Malgorzata Rozniewska, Jacek Stawinski, Adam Kraszewski
    Academic press:
    Organic Letters (rok: 2013, tom: 15, strony: 4082-4085), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/ol4016404 - link to the publication
  1. WSPOLCZESNE KONCEPCJE PRONUKLEOTYDOW ANTY -HIV
    Authors:
    J. Romanowska, M. Roiniewska, M. Sobkowski, A. Szymanska-Michalak, A. Dabrowska, A. Lipniacki, A. Piasek ,J. Boryski, J. Stawinski, A. Kraszewski
    Conference:
    57. Zjazd Polsidego Towarzystwa Chemicznego • l Stowarzyszenia Ineynierow i Technikow Przemyslu Chemicznego. Chemia-Nadzieje i Marzenia (rok: 2014, ), Wydawca: PTChem
    Data:
    konferencja Czestochowa, 14-18 wrzesnia 2014
    Status:
    Published

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