Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Pro-nucleotides based on mRNA cap structure - synthesis, biological and biophysical evaluation

2016/21/D/ST5/01654

Keywords:

cap structure mRNA lyposomes pro-nucleotides pro-drugs amidophosphates amidodiphospates phosphotriesters

Descriptors:

  • ST5_16:
  • ST5_23:
  • NZ1_1: Molecular biology

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Karolina Piecyk 

Number of co-investigators in the project: 6

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 476 450 PLN

Project start date (Y-m-d): 2017-01-27

Project end date (Y-m-d): 2021-07-26

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr (35 000 PLN)
  2. Komputer.
  3. Pompa olejowa (15 000 PLN)
  4. Tablet.
  5. Laptop z projektorem multimedialnym (8 954 PLN)
  6. Waga analityczna (2 szt.) (10 000 PLN)
  7. Liofilizator (70 000 PLN)
  8. Monitory.

Information in the final report

  • Publication in academic press/journals (5)
  1. Effect of HIV-1 TAT Peptide Fusion on 5′ mRNA Cap Analogs Cell Membrane Permeability and Translation Inhibition
    Authors:
    Karolina Piecyk Karolina Piecyk Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland More by Karolina Piecyk , Paulina Pietrow, Thomas Arnold, Remigiusz Worch, Nadejda L. Korneeva, and Marzena Jankowska-Anyszka
    Academic press:
    Bioconjugate Chemistry (rok: 2020, tom: 31, strony: 1156-1166), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.0c00080 - link to the publication
  2. Modified ARCA analogs providing enhanced translational properties of capped mRNAs.
    Authors:
    Kocmik I, Piecyk K, Rudzinska M, Niedzwiecka A, Darzynkiewicz E, Grzela R, Jankowska-Anyszka M
    Academic press:
    Cell Cycle (rok: 2018, tom: 17, strony: 1624-1636), Wydawca: Taylor
    Status:
    Published
    DOI:
    10.1080/15384101.2018.1486164. - link to the publication
  3. "Synthesis of the first double-functionalized dinucleotide mRNA cap analogue for its specific labeling"
    Authors:
    Piecyk K., Krynska P., Kaluzna J., Jankowska-Anyszka M.,
    Academic press:
    Tetrahedron Letters (rok: 2017, tom: 58, strony: 3037-3040), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetlet.2017.06.060 - link to the publication
  4. Isoxazole-containing 5′ mRNA cap analogues as inhibitors of the translation initiation process
    Authors:
    Karolina Piecyk, Maciej Lukaszewicz, Karol Kamel, Maria Janowska, Paulina Pietrow, Sebastian Kmiecik, Marzena Jankowska-Anyszka
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 96, strony: 45298), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103583 - link to the publication
  5. Application of phosphoramidate ProTide technology for the synthesis of 5' mRNA cap analogs modified within exocyclic amine group
    Authors:
    Izabela Siekierska, Maciej Lukaszewicz, Remigiusz Worch, Marzena Jankowska-Anyszka, Karolina Piecyka
    Academic press:
    ChemMedChem , Wydawca: European Chemical Societies Publishing
    Status:
    Submitted
    DOI:
    brak - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy