Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Synthesis and characterization of new molecular probes for monitoring activity of enzymes associated with RNA decapping activity in living cells

2018/31/B/ST5/03821

Keywords:

decapping RNA degradation fluorescent probes nucleotide synthesis nucleotide analogues kap mRNA

Descriptors:

  • ST5_16:
  • ST5_23:
  • NZ1_3: Biophysics

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Kowalska 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 654 400 PLN

Project start date (Y-m-d): 2019-07-26

Project end date (Y-m-d): 2024-07-25

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications
    Authors:
    9.Kleczewska N., Sikorski P.J., Warmińska Z., Markiewicz Ł., Kasprzyk R., Baran N., Kwapiszewska K., Karpińska A., Michalski J., Hołyst R., Kowalska J., Jemielity J.
    Academic press:
    Chemical Science (rok: 2021, tom: 12, strony: 10242-10251), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1SC02143E - link to the publication
  2. Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation
    Authors:
    Mamot A., Sikorski P.J., Siekierska A., de Witte P., Kowalska J., Jemielity J.
    Academic press:
    Nucleic Acids Research (rok: 2021, tom: 50, strony: Page e3), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkab867 - link to the publication
  3. Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9
    Authors:
    Marcelina Bednarczyk, Jessica K. Peters, Renata Kasprzyk, Jagoda Starek, Marcin Warminski, Tomasz Spiewla, Jeffrey S. Mugridge, John D. Gross, Jacek Jemielity, Joanna Kowalska
    Academic press:
    ACS CHEMICAL BIOLOGY (rok: 2022, tom: 17, strony: 1460−1471), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acschembio.2c00049 - link to the publication
  4. Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism
    Authors:
    Dorota Kubacka, Mateusz Kozarski, Marek R. Baranowski, Radoslaw Wojcik , Joanna Panecka-Hofman, Dominika Strzelecka , Jerome Basquin , Jacek Jemielity, Joanna Kowalska
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15(5), strony: 554), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15050554 - link to the publication
  5. Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo
    Authors:
    Marcin Warminski, Edyta Trepkowska, Miroslaw Smietanski, Pawel J. Sikorski, Marek R. Baranowski, Marcelina Bednarczyk, Hanna Kedzierska, Bartosz Majewski, Adam Mamot, Diana Papiernik, Agnieszka Popielec, Remigiusz A. Serwa, Brittany A. Shimanski, Piotr Sklepkiewicz, Marta Sklucka, Olga Sokolowska, Tomasz Spiewla, Diana Toczydlowska-Socha, Zofia Warminska, Karol Wolosewicz, Joanna Zuberek, Jeffrey S. Mugridge, Dominika Nowis, Jakub Golab, Jacek Jemielity, and Joanna Kowalska
    Academic press:
    Journal of the American Chemical Society (rok: 2024, tom: brak, strony: brak), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.3c12629 - link to the publication
  6. Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties
    Authors:
    Olga Perzanowska, Miroslaw Smietanski, Jacek Jemielity, Joanna Kowalska
    Academic press:
    Chemistry—A European Journal (rok: 2022, tom: 28, strony: e202201115), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/chem.202201115 - link to the publication
  7. Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs
    Authors:
    Mateusz Kozarski, Karolina Drazkowska, Marcelina Bednarczyk, MarcinWarminski, JacekJemielity, Joanna Kowalska
    Academic press:
    RSC Advances (rok: 2023, tom: 13, strony: 12809–12824), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d3ra00026e - link to the publication
  8. 5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR
    Authors:
    Marek R. Baranowski, Marcin Warmiński, Jacek Jemielity, Joanna Kowalska
    Academic press:
    Nucleic Acids Research (rok: 2020, tom: 48, strony: 8209–8224), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkaa470 - link to the publication
  9. Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation
    Authors:
    Tibble R.W., Depaix A., Kowalska J., Jemielity J., J.D. Gross
    Academic press:
    Nature Chemical Biology (rok: 2021, tom: 17, strony: 615-623), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41589-021-00774-x - link to the publication
  10. Chemical Modifications of mRNA Ends for Therapeutic Applications
    Authors:
    Marcin Warminski, Adam Mamot, Anaïs Depaix, Joanna Kowalska and Jacek Jemielity
    Academic press:
    Accounts of Chemical Research (rok: 2023, tom: 56, strony: 2814-2826), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.accounts.3c00442 - link to the publication

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