Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups
2012/07/B/ST5/03035
Keywords
Descriptors
- ST5_11: Synteza biomateriałów
- ST5_16: Chemia biologiczna
- NZ1_5: Inżynieria genetyczna
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Instytut Chemii Bioorganicznej PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
dr hab. Marcin Krzysztof Chmielewski
Number of co-investigators in the project: 4
Call
OPUS 4 – announced on 2012-09-15
- Amount awarded
- 891 560 PLN
- Project start date
- 2013-07-19
- Project end date
- 2017-07-18
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Zestaw wysokociśnieniow ej chromatografii cieczowej - wersja półpreparatywna. Cost: 305 000 PLN
Information in the final report
Publication in academic press/journals (2)
-
Mini-Review of the Phosphate Center Activation Strategy in Nucleoside Triphosphate Preparation
- Authors:
- Tomasz P. Kaczyński, Marcin K. Chmielewski
- Academic press:
- Mini-Reviews in Organic Chemistry (year: 2017, volume: 14, pages: E-pub), Publisher: Bentham Science
- Status:
- Published
- DOI:
- 10.2174/1570193X14666170420113635 – link to the publication
-
Stereoselective P-Cyclisation and Diastereoisomeric Purification of 5-Phenyl-3-(pyridin-2-yl)-1,3,2-oxazaphospholidine Formed from a Thermolabile Protecting Group
- Authors:
- Tomasz P. Kaczyński, Tomasz Manszewski and Marcin K. Chmielewski
- Academic press:
- European Journal of Organic Chemistry (year: 2016, volume: 14, pages: 2522–2527), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/ejoc.201501596 – link to the publication
Articles in post-conference publications (1)
-
Application of thermolabile protecting groups on triphosphates synthesis
- Authors:
- Kaczyński T., Romanowska J., Chmielewski M.K.
- Conference:
- 16th Symposium on Chemistry of Nucleic Acid Components (year: 2014, pages: Vol. 14, p. 291.), Publisher: M. Hocek, Ed.) Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague 2014
- Date:
- conference 8-13 czerwiec 2014
- Status:
- Published
Book publications / chapters in book publications (1)
-
2-Pyridinyl Thermolabile Groups as General Protectants for Hydroxyl, Phosphate, and Carboxyl Functions
- Authors:
- Jolanta Brzezinska, Agnieszka Witkowska, Tomasz P. Kaczyńnski, Dominika Krygier, Tomasz Ratajczak, Marcin K. Chmielewski
- Book:
- Current Protocols in Nucleic Acid Chemistry (year: 2017, volume: 68, pages: 2.20.1-2.20.25), Publisher: John Wiley & Sons
- Status:
- Published