Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

2012/07/B/ST5/03035

Keywords:

thermocyclization triphosphoates protecting groups DNA RNA nucleotides PCR

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_16:
  • NZ1_5: Genetic engineering

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Chmielewski 

Number of co-investigators in the project: 4

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 891 560 PLN

Project start date (Y-m-d): 2013-07-19

Project end date (Y-m-d): 2017-07-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw wysokociśnieniow ej chromatografii cieczowej - wersja półpreparatywna (305 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  • Book publications / chapters in book publications (1)
  1. Stereoselective P-Cyclisation and Diastereoisomeric Purification of 5-Phenyl-3-(pyridin-2-yl)-1,3,2-oxazaphospholidine Formed from a Thermolabile Protecting Group
    Authors:
    Tomasz P. Kaczyński, Tomasz Manszewski and Marcin K. Chmielewski
    Academic press:
    European Journal of Organic Chemistry (rok: 2016, tom: 14, strony: 2522–2527), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ejoc.201501596 - link to the publication
  2. Mini-Review of the Phosphate Center Activation Strategy in Nucleoside Triphosphate Preparation
    Authors:
    Tomasz P. Kaczyński, Marcin K. Chmielewski
    Academic press:
    Mini-Reviews in Organic Chemistry (rok: 2017, tom: 14, strony: E-pub), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570193X14666170420113635 - link to the publication
  1. Application of thermolabile protecting groups on triphosphates synthesis
    Authors:
    Kaczyński T., Romanowska J., Chmielewski M.K.
    Conference:
    16th Symposium on Chemistry of Nucleic Acid Components (rok: 2014, ), Wydawca: M. Hocek, Ed.) Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague 2014
    Data:
    konferencja 8-13 czerwiec 2014
    Status:
    Published
  1. 2-Pyridinyl Thermolabile Groups as General Protectants for Hydroxyl, Phosphate, and Carboxyl Functions
    Authors:
    Jolanta Brzezinska, Agnieszka Witkowska, Tomasz P. Kaczyńnski, Dominika Krygier, Tomasz Ratajczak, Marcin K. Chmielewski
    Book:
    Current Protocols in Nucleic Acid Chemistry (rok: 2017, tom: 68, strony: 2.20.1-2.20.25), Wydawca: John Wiley & Sons
    Status:
    Published

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