Projects funded by the NCN

How mutations in the dystrophin-encoding gene affect calcium homeostasis, energy metabolism and selected functions of va...

Call: OPUS 21 , Panel: NZ5

Principal investigator: prof. Krzysztof Olaf Zabłocki

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Identification of mTOR pathway deregulation mechanisms alternative to mutations in T-cell acute lymphoblastic leukemia (...

Call: PRELUDIUM 20 , Panel: NZ2

Principal investigator: Natalia Maćkowska-Maślak

Instytut Genetyki Człowieka PAN

Identifying the routes of electron transfer in respiratory alternative complex III by mutational and biochemical studies

Call: PRELUDIUM 20 , Panel: NZ1

Principal investigator: Katarzyna Maria Lorencik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Molecular mechanisms linking RNA polymerase III mutations to Hypomyelinating leukodystrophy (HLD).

Call: SONATA 16 , Panel: NZ2

Principal investigator: dr Tomasz Wojciech Turowski

Instytut Biochemii i Biofizyki PAN

Identification of cancer-driver mutations in non-coding parts of protein-coding genes and long non-coding RNA genes

Call: OPUS 20 , Panel: NZ5

Principal investigator: prof. Piotr Kozłowski

Instytut Chemii Bioorganicznej PAN

Experimental analysis of molecular determinants involved in epilepsy

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr hab. Vladimir Korzh

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

The effect of cancer somatic mutations in miRNA genes on the functioning of these genes and their potential role in canc...

Call: SONATA 16 , Panel: NZ2

Principal investigator: dr Paulina Małgorzata Gałka-Marciniak

Instytut Chemii Bioorganicznej PAN

Usefulness of liquid biopsy" in diagnostics, stratification, and monitoring of therapy in non-small cell lung cancer pat...

Call: PRELUDIUM BIS 2 , Panel: NZ5

Principal investigator: dr hab. Joanna Natalia Budna-Tukan

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

A cellular model for understanding gender differences in Leber's Hereditary Optic Neuropathy

Call: PRELUDIUM 2 , Panel: NZ3

Principal investigator: Agata Krystyna Kodroń

Uniwersytet Warszawski

Systematic genomic search for novel genes/variants in consanguineous families including males with reproductive failure

Call: OPUS 19 , Panel: NZ5

Principal investigator: prof. Maciej Krzysztof Kurpisz

Instytut Genetyki Człowieka PAN

Mutations of cis-regulatory elements as potential mechanism leading to chromatin inaccessibility and gene silencing in c...

Call: PRELUDIUM 19 , Panel: NZ2

Principal investigator: Adam Ustaszewski

Instytut Genetyki Człowieka PAN

Structure-function relationship in fibroblast growth factor signaling

Call: CEUS-UNISONO , Panel: NZ3

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski, Wydział Biotechnologii

Influence of oncogenic mutations on information transmission in the MAPK signaling pathway

Call: OPUS 18 , Panel: NZ2

Principal investigator: prof. Tomasz Lipniacki

Instytut Podstawowych Problemów Techniki Polska Akademia Nauk

Role of TP53 mutations in corticotroph pituitary tumors

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Monika Pękul

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Analysis of Escherichia coli ydiU mutation suppressors and detergent resistant membrane fraction as a way to discover fu...

Call: PRELUDIUM 18 , Panel: NZ1

Principal investigator: Monika Karasiewicz-Urbańska

Instytut Biochemii i Biofizyki PAN

Identification and functional characteristics of mtDNA mutations in canine mammary gland tumors based on genomic, epigen...

Call: OPUS 18 , Panel: NZ5

Principal investigator: prof. Brygida Bożena Ślaska

Uniwersytet Przyrodniczy w Lublinie

Effect of Embryonic Diapause on mitochondrial mutations inheritance in the mouse model of obesity.

Call: PRELUDIUM 18 , Panel: NZ3

Principal investigator: Łukasz Józef Gąsior

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

The use of evolutionary patterns in the optimization of chemotherapy of tuberculosis

Call: SONATA BIS 9 , Panel: NZ6

Principal investigator: dr Alina Ewa Minias

Instytut Biologii Medycznej PAN

Mutations in TP53 gene in canine mammary tumor and their clinical significance.

Call: PRELUDIUM 17 , Panel: NZ4

Principal investigator: Katarzyna Anna Roszkowska

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Medycyny Weterynaryjnej

Identification of new mutations in patients with head and neck paragangliomas (HNPGL) for better stratification of the c...

Call: PRELUDIUM 17 , Panel: NZ5

Principal investigator: Anna Frączkowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Association of constitutional BRCA1 methylation with genetic alterations in promoter region and genome-wide methylayion ...

Call: PRELUDIUM 16 , Panel: NZ1

Principal investigator: Karolina Marta Prajzendanc

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarsko-Biotechnologiczny i Medycyny Laboratoryjnej

Unsolved issues in molecular basis of primary ciliary dyskinesia (PCD), a motile ciliopathy - identification of large ge...

Call: OPUS 16 , Panel: NZ2

Principal investigator: prof. Ewa Maria Ziętkiewicz

Instytut Genetyki Człowieka PAN

Molecular characterisation of novel mutations in the gene encoding the luteinizing hormone/choriogonadotropin receptor (...

Call: PRELUDIUM 15 , Panel: NZ5

Principal investigator: dr Kamila Julita Adamczuk

Uniwersytet Medyczny w Lublinie

In search for new genes involved in primary ciliary dyskinesia pathogenesis: functional screening of candidate genes usi...

Call: PRELUDIUM 15 , Panel: NZ5

Principal investigator: Alicja Małgorzata Rabiasz

Instytut Genetyki Człowieka PAN

The role of HSP70 in the stabilization of p53 mutants in cancer cells

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: dr Milena Karolina Wiech

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Analysis of gene polymorphisms and mutations that play a role in Th17 and Treg cells function in patients with rheumatoi...

Call: SONATA 1 , Panel: NZ5

Principal investigator: dr Agnieszka Paradowska-Gorycka

Instytut Reumatologii im. prof. dr hab. med. Eleonory Reicher

Mutational load in children with prelingual deafness - searching for a novel predictive factor to assess the outcome of ...

Call: PRELUDIUM 14 , Panel: NZ5

Principal investigator: dr Dominika Daria Oziębło

Instytut Fizjologii i Patologii Słuchu

Indetification and functional analysis of mutations in VDAC3 encoding gene in sperm with low motility

Call: SONATA 13 , Panel: NZ1

Principal investigator: dr Andonis Karachitos

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Effect of heterozygous mutations and radiaton on expression of DNA repair genes- MRE11, RAD50 and NBN in the cells of ac...

Call: OPUS 1 , Panel: NZ5

Principal investigator: prof. Jerzy Stanisław Nowak

Instytut Genetyki Człowieka PAN

How activation of the Mec1/Tel1 kinase (human ATR/ATM) pathway in response to the nuclear genome damage influences the s...

Call: OPUS 13 , Panel: NZ3

Principal investigator: dr Aneta Edyta Kaniak-Golik

Instytut Biochemii i Biofizyki PAN

Genetic diversity in Kashubians: origin of recurrent pathogenic mutations and specificity of neutral genetic diversity p...

Call: OPUS 13 , Panel: NZ2

Principal investigator: prof. Beata Stefania Lipska-Ziętkiewicz

Gdański Uniwersytet Medyczny, Wydział Lekarski

Analysis of the influence of selected compounds on the translational readthrough of premature termination codons in gene...

Call: OPUS 1 , Panel: NZ4

Principal investigator: prof. Ewa Maria Ziętkiewicz

Instytut Genetyki Człowieka PAN

Whole-genome analysis of factors promoting instant and complex chromosome destabilizations in mitotically dividing diplo...

Call: OPUS 13 , Panel: NZ2

Principal investigator: prof. Ryszard Korona

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

Singular Perturbations Leading To Averaging Principles in Models Originating from Biology and Medicine.

Call: OPUS 13 , Panel: ST1

Principal investigator: prof. Adam Bobrowski

Politechnika Lubelska, Wydział Elektrotechniki i Informatyki

Postzygotic de novo mutations in peadiatric neurological/neurodevelopmental diseases.

Call: PRELUDIUM 13 , Panel: NZ4

Principal investigator: Anna Magdalena Walczak

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Study of transcriptional networks disruption on the development of liver cancer: functional analysis of the HNF4A gene m...

Call: OPUS 13 , Panel: NZ5

Principal investigator: dr Hiroaki Taniguchi

Instytut Genetyki i Hodowli Zwierząt PAN

Functional study of rare BRAF mutations on liver cancer development using CRISPR/Cas9 system

Call: PRELUDIUM 13 , Panel: NZ5

Principal investigator: Magdalena Śmiech

Instytut Genetyki i Hodowli Zwierząt PAN

Searching for mutations in COL4A3, COL4A4 and COL4A5 genes and defining their impact on clinical outcome in a national c...

Call: PRELUDIUM 13 , Panel: NZ5

Principal investigator: Olga Małgorzata Bielska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Skin-derived cells as a model for studying consequences of mutations in genes causing hereditary retinal dystrophies

Call: PRELUDIUM 12 , Panel: NZ5

Principal investigator: dr Aneta Ścieżyńska

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Molecular background of brain metastases in lung cancer

Call: SONATA 12 , Panel: NZ2

Principal investigator: dr Marcin Nicoś

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

Identification and comprehensive characterization of genomic variants associated with Gilles de la Tourette syndrome

Call: OPUS 12 , Panel: NZ2

Principal investigator: prof. Cezary Żekanowski

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Understanding of the functioning of mitochondrial ATP synthase by studying in yeast the phenotype of human pathology rel...

Call: OPUS 12 , Panel: NZ3

Principal investigator: dr hab. Róża Kucharczyk

Instytut Biochemii i Biofizyki PAN

Translational readthrough of premature termination codons (PTC readthrough) in genes mutated in primary ciliary dyskines...

Call: PRELUDIUM 12 , Panel: NZ4

Principal investigator: Maciej Jan Dąbrowski

Instytut Genetyki Człowieka PAN

Analysis of somatic mutations in miRNA and miRNA-biogenesis genes to identify new therapeutic targets and biomarkers of ...

Call: MAESTRO 8 , Panel: NZ2

Principal investigator: prof. Piotr Kozłowski

Instytut Chemii Bioorganicznej PAN

Resolving structure and functions of RECQL4 and BLM helicases to understand consequences of deleterious genetic alterati...

Call: HARMONIA 8 , Panel: NZ3

Principal investigator: prof. Bożena Kamińska-Kaczmarek

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Oncogenic mechanisms of DIS3 mutations

Call: MAESTRO 8 , Panel: NZ4

Principal investigator: prof. Andrzej Stanisław Dziembowski

Instytut Biochemii i Biofizyki PAN

Identifying molecular events for transformation of early colorectal polyps. Studies with APC1311-targeted pigs.

Call: SONATA 11 , Panel: NZ2

Principal investigator: dr hab. Monika Dragan

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

The genetic diversity of avian influenza virus in the course of experimental infection - the impact of bottleneck effect...

Call: OPUS 11 , Panel: NZ6

Principal investigator: dr hab. Krzysztof Wojciech Śmietanka

Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy

The influence of ALS-associated FUS mutations on U7 snRNP activity and the expression of core canonical histone genes in...

Call: OPUS 11 , Panel: NZ1

Principal investigator: dr Katarzyna Dorota Raczyńska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii