Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The influence of ALS-associated FUS mutations on U7 snRNP activity and the expression of core canonical histone genes in human cells

2016/21/B/NZ1/00232

Keywords:

U7 snRNP FUS protein Amyotrophic Lateral Sclerosis histone gene expression

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_3: Proteomics
  • NZ2_1: Molecular genetics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Raczyńska 

Number of co-investigators in the project: 4

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 402 400 PLN

Project start date (Y-m-d): 2017-01-27

Project end date (Y-m-d): 2021-01-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do elekreoforezy (1 672 PLN)
  2. Komputer z oprogramowaniem (2 szt.) (10 000 PLN)
  3. kołyska, rotory (8 731 PLN)
  4. drukarka (997 PLN)
  5. Notebook (3 049 PLN)
  6. monitor.
  7. wytrząsara mini kołyskowej.
  8. Inkubator CO2 do hodowli komórek wraz w wyposażeniem (60 000 PLN)
  9. Turbocycler (32 389 PLN)
  10. Aparat do transferu (7 269 PLN)
  11. Llodówka z zamrażarką (10 000 PLN)
  12. Vortex mixer (867 PLN)
  13. termoblok, miniwirówki, zestawy pipet, zestawy szyb do elektroforezy pionowej (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. U7 snRNA: A tool for gene therapy
    Authors:
    Gadgil Ankur, Katarzyna Dorota Raczyńska
    Academic press:
    Journal of Gene Medicine (rok: 2021, tom: 1, strony: 45306), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jgm.3321 - link to the publication
  2. ALS-linked FUS mutants affect localization of U7 snRNP and replication-dependent histone gene expression in human cells
    Authors:
    Ankur Gadgil, Agata Stępień, Agnieszka Walczak, Agnes Nishimura, Marc-David Ruepp, Katarzyna Dorota Raczyńska
    Academic press:
    Scientific Report (rok: 2021, tom: 11 (1), strony: 11868), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-91453-3 - link to the publication
  3. Family of pentatricopeptide repeat proteins in non-plant organisms
    Authors:
    Czubak Pawel, Raczynska Katarzyna Dorota
    Academic press:
    Internal Medicine Review (rok: 2018, tom: 4, strony: brak), Wydawca: Internal Medicine Review
    Status:
    Published