Projects funded by the NCN
The influence of ALS-associated FUS mutations on U7 snRNP activity and the expression of core canonical histone genes in human cells
2016/21/B/NZ1/00232
Keywords:
U7 snRNP FUS protein Amyotrophic Lateral Sclerosis histone gene expression
Descriptors:
- NZ1_1: Molecular biology
- NZ2_3: Proteomics
- NZ2_1: Molecular genetics
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii
woj. wielkopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 11 - announced on 2016-03-15
Amount awarded: 1 402 400 PLN
Project start date (Y-m-d): 2017-01-27
Project end date (Y-m-d): 2021-01-26
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Aparat do elekreoforezy (1 672 PLN)
- Komputer z oprogramowaniem (2 szt.) (10 000 PLN)
- kołyska, rotory (8 731 PLN)
- drukarka (997 PLN)
- Notebook (3 049 PLN)
- monitor.
- wytrząsara mini kołyskowej.
- Inkubator CO2 do hodowli komórek wraz w wyposażeniem (60 000 PLN)
- Turbocycler (32 389 PLN)
- Aparat do transferu (7 269 PLN)
- Llodówka z zamrażarką (10 000 PLN)
- Vortex mixer (867 PLN)
- termoblok, miniwirówki, zestawy pipet, zestawy szyb do elektroforezy pionowej (15 000 PLN)
Information in the final report
- Publication in academic press/journals (3)
- U7 snRNA: A tool for gene therapyAuthors:Gadgil Ankur, Katarzyna Dorota RaczyńskaAcademic press:Journal of Gene Medicine (rok: 2021, tom: 1, strony: 45306), Wydawca: WileyStatus:PublishedDOI:10.1002/jgm.3321 - link to the publication
- ALS-linked FUS mutants affect localization of U7 snRNP and replication-dependent histone gene expression in human cellsAuthors:Ankur Gadgil, Agata Stępień, Agnieszka Walczak, Agnes Nishimura, Marc-David Ruepp, Katarzyna Dorota RaczyńskaAcademic press:Scientific Report (rok: 2021, tom: 11 (1), strony: 11868), Wydawca: NatureStatus:PublishedDOI:10.1038/s41598-021-91453-3 - link to the publication
- Family of pentatricopeptide repeat proteins in non-plant organismsAuthors:Czubak Pawel, Raczynska Katarzyna DorotaAcademic press:Internal Medicine Review (rok: 2018, tom: 4, strony: brak), Wydawca: Internal Medicine ReviewStatus:PublishedDOI:brak - link to the publication