The influence of ALS-associated FUS mutations on U7 snRNP activity and the expression of core canonical histone genes in human cells
2016/21/B/NZ1/00232
Keywords
Descriptors
- NZ1_1: Biologia molekularna
- NZ2_3: Proteomika
- NZ2_1: Genetyka molekularna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 11 – announced on 2016-03-15
- Amount awarded
- 1 402 400 PLN
- Project start date
- 2017-01-27
- Project end date
- 2021-01-26
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Aparat do elekreoforezy. Cost: 1 672 PLN
- Aparat do transferu. Cost: 7 269 PLN
- Inkubator CO2 do hodowli komórek wraz w wyposażeniem. Cost: 60 000 PLN
- Komputer z oprogramowaniem (2 pcs). Cost: 10 000 PLN
- Llodówka z zamrażarką. Cost: 10 000 PLN
- Notebook. Cost: 3 049 PLN
- Turbocycler. Cost: 32 389 PLN
- Vortex mixer. Cost: 867 PLN
- drukarka. Cost: 997 PLN
- kołyska, rotory. Cost: 8 731 PLN
- monitor.
- termoblok, miniwirówki, zestawy pipet, zestawy szyb do elektroforezy pionowej. Cost: 15 000 PLN
- wytrząsara mini kołyskowej.
Information in the final report
Publication in academic press/journals (3)
-
Family of pentatricopeptide repeat proteins in non-plant organisms
- Authors:
- Czubak Pawel, Raczynska Katarzyna Dorota
- Academic press:
- Internal Medicine Review (year: 2018, volume: 4, pages: brak), Publisher: Internal Medicine Review
- Status:
- Published
-
ALS-linked FUS mutants affect localization of U7 snRNP and replication-dependent histone gene expression in human cells
- Authors:
- Ankur Gadgil, Agata Stępień, Agnieszka Walczak, Agnes Nishimura, Marc-David Ruepp, Katarzyna Dorota Raczyńska
- Academic press:
- Scientific Report (year: 2021, volume: 11 (1), pages: 11868), Publisher: Nature
- Status:
- Published
- DOI:
- 10.1038/s41598-021-91453-3 – link to the publication
-
U7 snRNA: A tool for gene therapy
- Authors:
- Gadgil Ankur, Katarzyna Dorota Raczyńska
- Academic press:
- Journal of Gene Medicine (year: 2021, volume: 1, pages: 46037), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/jgm.3321 – link to the publication