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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Oncogenic mechanisms of DIS3 mutations

2016/22/A/NZ4/00380

Keywords:

multiple myeloma exosome DIS3 immunoglobulin class switch recombination AID

Descriptors:

  • NZ4_12: Other related subjects
  • NZ2_1: Molecular genetics
  • NZ1_1: Molecular biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Dziembowski 

Number of co-investigators in the project: 8

Call: MAESTRO 8 - announced on 2016-06-15

Amount awarded: 3 490 750 PLN

Project start date (Y-m-d): 2017-05-19

Project end date (Y-m-d): 2025-05-18

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Somatic DIS3 mutations in Multiple Myeloma arise early in clonal evolution, but are later counterselected due to toxicity
    Authors:
    Tomasz M Kuliński, Olga Gewartowska, Seweryn Mroczek, Marcin Szpila, Katarzyna Sałas, Vladyslava Liudkovska, Andrzej Dziembowski
    Academic press:
    Life Science Alliance , Wydawca: Rockefeller University Press
    Status:
    Submitted
    DOI:
    10.1101/2023.07.27.550471v2.abstract - link to the publication
  2. Multiple Myeloma associated DIS3 mutations drive AID-dependent IgH Translocations
    Authors:
    Tomasz M Kulinski, Olga Gewartowska, Mélanie Mahe, Karolina Kasztelan, Janina Durys, Bertrand Seraphin, Andrzej Dziembowski
    Academic press:
    EMBO reports (rok: 2023, ), Wydawca: EMBO
    Status:
    Submitted
    DOI:
    10.1101/2023.07.27.550610v1.abstract - link to the publication
  3. DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
    Authors:
    Michał Brouze, Marcin Szpila, Areta Czerwińska, Wiktor Antczak, Seweryn Mroczek, Tomasz M. Kuliński1, Anna Hojka-Osińska, Dominik Cysewski, Dorota Adamska, Jakub Gruchota, Ewa Borsuk and Andrzej Dziembowski
    Academic press:
    Nucleic Acids Research , Wydawca: Oxford University Press
    Status:
    Submitted
    DOI:
    10.1101/2022.12.14.520403 - link to the publication

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