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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Mutations in mitochondrial ATP6 gene, identified in cancer and myopathies, and their impact on ATP synthase and cell metabolism in yeast S. cerevisiae.

2013/11/B/NZ1/02102

Keywords:

yeast mitochondria syntaza ATP ATP6 myopahies nowotwory

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Róża Kucharczyk 

Number of co-investigators in the project: 3

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 504 500 PLN

Project start date (Y-m-d): 2014-07-04

Project end date (Y-m-d): 2017-07-03

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. kasety z ekranami do żeli radioaktywnych do czytnika Phosphoimager (2 szt.) (11 000 PLN)
  2. zestaw komputerowy (5 000 PLN)
  3. Wylewarka (4 741 PLN)
  4. Zestaw startowy do elektrotranferu wraz aparatem do migracji zeli (7 000 PLN)
  5. Stołowa wirówka z chłodzeniem na 18 eppendorfów (20 000 PLN)
  6. zasilacz do elektroforezy (9 000 PLN)
  7. aparat do elektroforezy do gotowych zeli natywnych (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Identification of G8969>A in mitochondrial ATP6 gene that severely compromises ATP synthase function in a patient with IgA nephropathy.
    Authors:
    Shuzhen Wen,*, Katarzyna Niedzwiecka,*, Weiwei Zhao, Shutian Xu, Shaoshan Liang, Xiaodong Zhu, Honglang Xie, Déborah Tribouillard-Tanvier, Marie-France Giraud, Caihong Zeng, Alain Dautant, Róża Kucharczyk, Zhihong Liu, Jean-Paul di Rago, Huimei Chen
    Academic press:
    Scientific Report (rok: 2016, tom: 6, strony: 36313), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/srep36313 - link to the publication
  2. Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast.
    Authors:
    Katarzyna Niedzwiecka, Renata Tisi, Sara Penna, Lichocka M, Danuta Plochocka , Roza Kucharczyk
    Academic press:
    BBA-Mol Cell research (rok: 2018, tom: 1865, strony: 117-131), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.003 - link to the publication
  3. Revisiting Mitochondrial pH with an Improved Algorithm for Calibration of the Ratiometric 5(6)-carboxy-SNARF-1 Probe Reveals Anticooperative Reaction with H+ Ions and Warrants Further Studies of Organellar pH
    Authors:
    Żurawik TM, Pomorski A, Belczyk-Ciesielska A, Goch G, Niedźwiedzka K, Kucharczyk R, Krężel A, Bal W.
    Academic press:
    PLOS One (rok: 2016, tom: 11(8), strony: e0161353), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0161353 - link to the publication
  1. Exploring the human ATP synthase proton channel
    Authors:
    Natalia Skoczen, Krystyna Binko, Alain Dautant, Jean-Paul di Rago, Roza Kucharczyk
    Conference:
    European Bioenergetic Conference EBEC 2016 (rok: 2016, ), Wydawca: BBA-Bioenergetics, ELSEVIER
    Data:
    konferencja 2-7.07.2016
    Status:
    Published
    DOI:
    link to the publication
  2. Mutations in mitochondrial ATP6 gene encoding subunit of ATP synthase and their impact on cell physiology in yeast S. cerevisiae
    Authors:
    Katarzyna Niedzwiecka, Marek Skoneczny, Renata Tisi, Roza Kucharczyk
    Conference:
    European Bioenergetics Conference EBEC 2016 (rok: 2016, ), Wydawca: Biochimica et Biophysica Acta (BBA) - Bioenergetics, ELSEVIER
    Data:
    konferencja 2-7.07.2016
    Status:
    Published
    DOI:
    link to the publication

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