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Information on the principal investigator and host institution

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Analysis of the effect of the DIS3 mutations on the viability, development and tumor formation in mice

2013/10/M/NZ4/00299

Keywords:

DIS3 multiple myeloma mouse exosome

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_8: Stem cell biology
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Andrzej Dziembowski 

Number of co-investigators in the project: 9

Call: HARMONIA 5 - announced on 2013-06-14

Amount awarded: 994 500 PLN

Project start date (Y-m-d): 2014-05-19

Project end date (Y-m-d): 2017-05-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  1. DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
    Authors:
    Michał Brouze, Marcin Szpila, Areta Czerwińska, Wiktor Antczak, Seweryn Mroczek, Tomasz M. Kuliński1, Anna Hojka-Osińska, Dominik Cysewski, Dorota Adamska, Jakub Gruchota, Ewa Borsuk and Andrzej Dziembowski
    Academic press:
    Nucleic Acids Research (tom: x, strony: x), Wydawca: Oxford Academic
    Status:
    Submitted
    DOI:
    10.1101/2022.12.14.520403 - link to the publication
  2. Multiple Myeloma associated DIS3 mutations drive AID-dependent IgH Translocations
    Authors:
    Tomasz M Kulinski, Olga Gewartowska, Mélanie Mahe, Karolina Kasztelan, Janina Durys, Bertrand Seraphin, Andrzej Dziembowski
    Academic press:
    EMBO Journal (tom: x, strony: x), Wydawca: Wiley
    Status:
    Submitted
    DOI:
    10.1101/2023.07.27.550610 - link to the publication
  3. 5′ and 3′ modifications controlling RNA degradation: from safeguards to executioners
    Authors:
    Dominique Gagliardi, Andrzej Dziembowski
    Academic press:
    Philos Trans R Soc Lond B Biol Sci. (rok: 2018, tom: 373, strony: 45296), Wydawca: The Royal Society Publishing
    Status:
    Published
    DOI:
    10.1098/rstb.2018.0160 - link to the publication
  4. Recurrent Multiple Myeloma DIS3 alleles arise early but are later counter-selected due to toxicity
    Authors:
    Tomasz Kulinski, Olga Gewartowska, Seweryn Mroczek, Marcin Szpila, Katarzyna Salas, Vladyslava Liudkovska, Andrzej Dziembowski
    Academic press:
    EMBO Journal (tom: x, strony: x), Wydawca: Wiley
    Status:
    Submitted
    DOI:
    10.1101/2023.07.27.550471 - link to the publication

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