Projects funded by the NCN

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Tudek

Instytut Biochemii i Biofizyki PAN

The assessment of cysteinyl leukotriene receptor antagonist role in inhibition of atherosclerosis, proliferation and its...

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Paweł Maga

Uniwersytet Jagielloński, Collegium Medicum

NADPH oxidase genes expression in peripheral blood mononuclear cells (PBMC) in anti-TNF alpha-treated rheumatoid arthrit...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Tomasz Wysocki

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

Cellular mechanisms and effects in vivo of selective lactate dehydrogenase A inhibitors in experimental models of mesoth...

Call: OPUS 16 , Panel: NZ7

Principal investigator: prof. Ryszard Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

Definition of targetable signaling pathways in chronic lymphocytic leukemia patients with rationale to novel therapy wit...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Joanna Knap-Stępień

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

Impact of Polycomb Complex PRC1 inhibition on autophagy process in endometrial and breast cancer cells

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Aleksandra Szustka

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Dual action mode inhibitors of urease and their anti-virulent activity against Helicobacter pylori and Cryptococcus neof...

Call: OPUS 16 , Panel: NZ6

Principal investigator: prof. Artur Mucha

Politechnika Wrocławska

Studies on mechanisms of GABAergic plasticity in the interneurons and pyramidal cells in mouse hippocampus

Call: OPUS 16 , Panel: NZ4

Principal investigator: prof. Jerzy Mozrzymas

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

The significance of cancer specific PFK-II (PFKFB3 and PFKFB4) isoenzymes inhibition in overcoming resistance to BRAF in...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Sonia Trojan

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

Deciphering molecular mechanism of CDK8 kinase inhibitors action in acute myeloid leukemia

Call: SONATA BIS 8 , Panel: NZ2

Principal investigator: dr hab. Michał Mikula

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Extreme language control: activation and inhibition as bilingual control mechanisms in conference interpreting

Call: SONATA BIS 8 , Panel: HS2

Principal investigator: dr hab. Agnieszka Chmiel

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Anglistyki

Association of TXNDC5 and calreticulin with decreased ER stress, allowing resistant multiple myeloma cells to by-pass pr...

Call: PRELUDIUM 15 , Panel: NZ5

Principal investigator: Tadeusz Kubicki

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

Significance of the TNF, TNFR1, TNFR2, TRAF1, TRAF6 and TACE gene polymorphisms, clinical parameters and biomarkers for ...

Call: OPUS 1 , Panel: NZ5

Principal investigator: dr hab. Jerzy Świerkot

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

BET Bromodomain Inhibitors and improvement of glioblastoma therapy

Call: OPUS 14 , Panel: NZ5

Principal investigator: prof. Witold Korytowski

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Studies of alkylation mechanism of DNA oligomers using new Top I inhibitors from camptothecin family by physical organic...

Call: OPUS 14 , Panel: ST4

Principal investigator: prof. Lech Kozerski

Narodowy Instytut Leków

Molecular origins of mechanisms governing biological functions of enzymes with buried actives sites: substrate inhibitio...

Call: SONATA BIS 7 , Panel: NZ1

Principal investigator: dr hab. Jan Brezovsky

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Molecular mechanism of action and therapeutic effect of 5-aza-2'-deoxycytidine and topoisomerase inhibitors combination ...

Call: OPUS 13 , Panel: NZ5

Principal investigator: dr hab. Wojciech Kałas

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Proteomic analysis of myeloma plasma cells to determine proteins and pathways involved in acquired resistance to proteas...

Call: OPUS 13 , Panel: NZ5

Principal investigator: dr hab. Dominik Dytfeld

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

Optical and time-resolved spectroscopy for hypothesis veryfication of the conducting by mTS the reductive reaction with ...

Call: PRELUDIUM 13 , Panel: NZ1

Principal investigator: Małgorzata Prokopowicz

Uniwersytet Warszawski, Wydział Fizyki

Design of new small molecular regulators (inhibitors, activators) of the catalytic activity of adenylate kinases. Molecu...

Call: OPUS 13 , Panel: ST4

Principal investigator: dr Anna Kozakiewicz-Piekarz

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Chemii

Influence of nematode gender for inhibiting immunological response mechanism by dendritic cells in mice.

Call: PRELUDIUM 13 , Panel: NZ6

Principal investigator: Marta Maruszewska-Cheruiyot

Uniwersytet Warszawski, Wydział Biologii

CBR1-dependent metabolism and ABCB1-dependent effux of doxorubicin - search for a novel mechanism of reversing resistanc...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: Kamil Piska

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Structural studies on inhibition mechanisms of enzymes belonging to USP family, which remove ubiquitin from eukaryotic p...

Call: SONATINA 1 , Panel: NZ1

Principal investigator: dr Marcin Ziemniak

Uniwersytet Warszawski, Wydział Chemii

Insights into biological activity and mechanism of action of novel styrylquinazoline derivatives as tyrosine kinase inhi...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Katarzyna Malarz

Uniwersytet Śląski w Katowicach, Wydział Matematyki, Fizyki i Chemii

Evaluation of primary and secondary molecular disorders determinig drug resistance from a group of proteasome inhibitors...

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Tadeusz Robak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the colorectal cancer treatment

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Adam Dziki

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Molecular characteristic of quorum sensing inhibition by selected essential oils in Pseudomonas spp. isolated from foods

Call: SONATA 12 , Panel: NZ9

Principal investigator: dr hab. Kamila Myszka

Uniwersytet Przyrodniczy w Poznaniu, Wydział Nauk o Żywności i Żywieniu

Serum PAD-activity: Risk Factor in Development and Novel Biomarker in Rheumatoid Arthritis

Call: OPUS 12 , Panel: NZ5

Principal investigator: dr hab. Piotr Mydel

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Identification of the mechanism of sensitization of human ovarian cancer cells to anticancer drugs by the DNA double str...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Anna Macieja

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Precision medicine-guided synthetic lethality targeting DNA repair to eradicate solid tumors

Call: HARMONIA 8 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

UNIWERSYTET ŁÓDZKI, Wydział Biologii i Ochrony Środowiska

Structure and function characterization of newly discovered unique inhibitors of proteases

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Molecular aspects of interference with the thymidylate synthase-catalyzed reaction mechanism by the slow-binding inhibit...

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Wojciech Rode

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the primary open-angle glaucoma treatmen...

Call: OPUS 11 , Panel: NZ5

Principal investigator: prof. Ireneusz Majsterek

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Functional carbon based coatings on titanium substrate, modified by laser ablation designed for the integration with car...

Call: PRELUDIUM 11 , Panel: ST8

Principal investigator: Klaudia Trembecka-Wójciga

Instytut Metalurgii i Inżynierii Materiałowej im. Aleksandra Krupkowskiego Polskiej Akademii Nauk

Tick-borne encephalitis virus - search for mechanisms useful in treatment and prophylaxis.

Call: SONATA 10 , Panel: NZ6

Principal investigator: dr hab. Ewelina Król

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Molecular mechanism of action of substances decreasing the synthesis of glycosaminoglycans in terms of their potential u...

Call: OPUS 1 , Panel: NZ1

Principal investigator: dr hab. Magdalena Gabig-Cimińska

Uniwersytet Gdański, Wydział Biologii

The role of cognitive inhibition in the involuntary mental time travel.A comprehensive investigation of involuntary auto...

Call: SONATA 10 , Panel: HS6

Principal investigator: dr Krystian Barzykowski

Uniwersytet Jagielloński, Wydział Filozoficzny

Protein and gene expression analysis in the course of renal cancer stem-like cells' primary resistance to sorafenib in h...

Call: PRELUDIUM 9 , Panel: NZ5

Principal investigator: Zofia Bielecka

Wojskowy Instytut Medyczny