Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular aspects of interference with the thymidylate synthase-catalyzed reaction mechanism by the slow-binding inhibitor N4-hydroxy-dCMP

2016/21/B/NZ1/00288

Keywords:

Thymidylate synthase Enzymatic catalysis Inhibition mechanism NMR QM/MM calculations

Descriptors:

  • NZ1_2: Biochemistry
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Rode 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 724 600 PLN

Project start date (Y-m-d): 2017-03-08

Project end date (Y-m-d): 2022-03-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Moduł do epi-fluorescencji (15 000 PLN)
  2. Program Scigress (Fujitsu Kyushu Systems Limited; w Polsce jest przedstawicielstwo) (14 000 PLN)
  3. Sterowany komputerowo system galvo-laserowy (fiber laser).
  4. Aparat elektroforetyczny (mini gel system) z zasilaczem (15 000 PLN)
  5. Spektrofotometr UV-VIS z wyposażeniem do badań kinetycznych (termostatyzowany automatyczny zmieniacz kuwet) (56 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Advanced Spectroscopy and APBS modeling for determination of the role of His190 and Trp103 in mouse thymidylate synthase interaction with selected dUMP analogues.
    Authors:
    Prokopowicz M , Jarmuła A, Casamayou-Boucau Y, Gordon F, Ryder A, Sobich J, Maj P, Cieśla J, Zieliński Z, Fita P, Rode W
    Academic press:
    Int J Mol Sci 2661 (rok: 2021, tom: 22,, strony: praca 2661), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22052661 - link to the publication
  2. Molecular Mechanism of Thymidylate Synthase Inhibition by N4-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.
    Authors:
    Maj P, Jarmuła A, Wilk P, Prokopowicz M, Rypniewski W, Zieliński Z, Dowierciał A, Bzowska A, Rode W
    Academic press:
    Int J Mol Sci (rok: 2021, tom: 22, strony: praca 4758), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094758 - link to the publication
  3. Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP.
    Authors:
    Sobich J, Prokopowicz M, Maj P, Wilk P, Zieliński Z, Frączyk T, Rode W.
    Academic press:
    Arch Biochem Biophys (rok: 2019, tom: 674, strony: 108106), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2019.108106 - link to the publication
  4. Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities.
    Authors:
    Maj P, Mori M , Sobich J, Markowicz J, Uram Ł, Zieliński Z, Quaglio D, Calcaterra A, Cau Y, Botta B, Rode W
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 2894), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25122894 - link to the publication
  1. Structural insight into thymidylate synthase inhibition by N4-OH-dCMP
    Authors:
    Maj P, Wilk P, Jarmuła A, Dowierciał A, Rode W
    Conference:
    14th International School and Symposium on Synchrotron Radiation in Natural Science, Zakopane (rok: 2019, ), Wydawca: Polish Synchrotron Radiation Society
    Data:
    konferencja 9-14 czerwca 2019
    Status:
    Published

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