Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Precision medicine-guided synthetic lethality targeting DNA repair to eradicate solid tumors

2016/22/M/NZ7/00375

Keywords:

syntetyczna letalność naprawa DNA guzy lite medycyna spersonalizowana inhibitory białek naprawy pęknięć dwunicowych DNA

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Śliwiński 

Number of co-investigators in the project: 10

Call: HARMONIA 8 - announced on 2016-06-15

Amount awarded: 923 000 PLN

Project start date (Y-m-d): 2017-04-13

Project end date (Y-m-d): 2022-02-12

Project duration:: 58 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Class I HDAC Inhibition Leads to a Downregulation of FANCD2 and RAD51, and the Eradication of Glioblastoma Cells
    Authors:
    Drzewiecka M, Jaśniak D, Barszczewska-Pietraszek G, Czarny P, Kobrzycka A, Wieczorek M, Radek M, Szemraj J, Skorski T, Śliwiński T.
    Academic press:
    Journal of Personalized Medicine (rok: 2023, tom: 13, strony: 1315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jpm13091315 - link to the publication
  2. RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies
    Authors:
    Toma M, Sullivan-Reed K, Śliwiński T, Skorski T
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 1561), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11101561 - link to the publication
  3. Synthetic lethality targeting Polθ
    Authors:
    Małgorzata Drzewiecka, Gabriela Barszczewska-Pietraszek, Piotr Czarny, Tomasz Skorski, Tomasz Śliwiński
    Academic press:
    Genes (rok: 2022, tom: 13, strony: 1101), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13061101 - link to the publication
  4. Histone Deacetylases (HDAC) Inhibitor—Valproic Acid Sensitizes Human Melanoma Cells to Dacarbazine and PARP Inhibitor
    Authors:
    Drzewiecka M, Gajos-Michniewicz A, Hoser G, Jaśniak D, Barszczewska-Pietraszek G, Sitarek P, Czarny P, Piekarski J, Radek M, Czyż M, Skorski T, Śliwiński T
    Academic press:
    Genes (rok: 2023, tom: 14(6), strony: 1295-1307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes14061295 - link to the publication
  5. DNA double strand break repair - related synthetic lethality.
    Authors:
    Toma M, Skorski T, Sliwinski T.
    Academic press:
    Curr Med Chem (rok: 2018, tom: 25, strony: 13516), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867325666180201114306 - link to the publication
  6. Eradication of LIG4-defficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent
    Authors:
    Toma M, Witusik-Perkowska M, Szwed M, Stawski R, Szemraj J, Drzewiecka M, Nieborowska-Skorska M, Radek M, Kolasa P, Matlawska-WasowskaK Sliwinski T, Skorski T
    Academic press:
    Oncotarget (rok: 2018, tom: 9, strony: 36867-36877), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.26409 - link to the publication

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