Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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CBR1-dependent metabolism and ABCB1-dependent effux of doxorubicin - search for a novel mechanism of reversing resistance of cancer cells

2017/25/N/NZ7/01382

Keywords:

resistance drug metabolism P-glycoprotein chemosensitizing ABCB1 inhibitors

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ1_1: Molecular biology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Kamil Piska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 180 000 PLN

Project start date (Y-m-d): 2018-01-26

Project end date (Y-m-d): 2021-09-25

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Sonikator (13 280 PLN)
  2. Zestaw do western blott (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Carbonyl reduction pathway in hepatic in vitro metabolism of anthracyclines: Impact of structure on biotransformation rate
    Authors:
    Kamil Piska, Marek Jamrozik, Paulina Koczurkiewicz-Adamczyk, Adam Bucki, Paweł Żmudzki, Marcin Kołaczkowski, Elżbieta Pękala
    Academic press:
    Toxicology Letters (rok: 2021, tom: 342, strony: 50-57), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2021.02.001 - link to the publication
  2. Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance
    Authors:
    Kamil Piska, Paulina Koczurkiewicz-Adamczyk, Marek Jamrozik, Adam Bucki, Marcin Kołaczkowski, Elżbieta Pękala
    Academic press:
    Xenobiotica (rok: 2023, tom: nie nadano (spodziewany 54), strony: nie nadano (roboczo 1-11)), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/00498254.2023.2264391 - link to the publication

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