Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Dual action mode inhibitors of urease and their anti-virulent activity against Helicobacter pylori and Cryptococcus neoformans

2018/31/B/NZ6/02017

Keywords:

infections Helicobacter fungal pathogens covalent and metal-binding catechols organophosphorus and organoselenium compounds

Descriptors:

  • NZ6_4: Bacteriology
  • ST5_16:
  • NZ1_2: Biochemistry

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Artur Mucha 

Number of co-investigators in the project: 8

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 629 000 PLN

Project start date (Y-m-d): 2019-09-02

Project end date (Y-m-d): 2023-09-01

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Homogenizator ultradzwiękowy (22 000 PLN)
  2. Mikroskop stereoskopowy (28 000 PLN)
  3. Chłodziarko-zamrażarka.
  4. Inkubator z wytrząsaniem (56 000 PLN)
  5. System oczyszczania białek ÄKTA pure z wyposażeniem i kolumnami chromatograficznymi (270 000 PLN)
  6. Zestaw dwóch inkubatorów z wytrząsaniem.
  7. Autoklaw.
  8. Dysk twardy.
  9. Wyparka rotacyjna z pompą (21 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Rational development of bacterial ureases inhibitors
    Authors:
    Saurabh Loharch, Łukasz Berlicki
    Academic press:
    The Chemical Record (rok: 2022, tom: 22, strony: e202200026), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/tcr.202200026 - link to the publication
  2. Inhibitory activity of catecholic phosphonic and phosphinic acids against Helicobacter pylori ureolysis
    Authors:
    Marta Maślanka, Wojciech Tabor, Paweł Krzyżek, Agnieszka Grabowiecka, Łukasz Berlicki, Artur Mucha
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2023, tom: 257, strony: 115528), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2023.115528 - link to the publication
  3. Covalent Inhibition of Bacterial Urease by Bifunctional Catechol-Based Phosphonates and Phosphinates
    Authors:
    Aikaterini Pagoni, Agnieszka Grabowiecka, Wojciech Tabor, Artur Mucha, Stamatia Vassiliou, Łukasz Berlicki
    Academic press:
    Journal of Medicinal Chemistry (rok: 2021, tom: 64, strony: 404–416), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.0c01143 - link to the publication
  4. Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action
    Authors:
    Katarzyna Macegoniuk, Wojciech Tabor, Luca Mazzei, Michele Cianci, Mirosław Giurg, Kamila Olech, Małgorzata Burda-Grabowska, Rafał Kaleta, Agnieszka Grabowiecka, Artur Mucha, Stefano Ciurli, Łukasz Berlicki
    Academic press:
    Journal of Medicinal Chemistry (rok: 2023, tom: 66, strony: 2054−2063), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.2c01799 - link to the publication
  5. Phosphinic acid-based enzyme inhibitors
    Authors:
    Stamatia Vassiliou, Aikaterini Pagoni, Ewelina Węglarz-Tomczak, Michał Talma, Wojciech Tabor, Agnieszka Grabowiecka, Łukasz Berlicki, Artur Mucha
    Academic press:
    Phosphorus, Sulfur, and Silicon and the Related Elements (rok: 2022, tom: 197, strony: 451–456), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10426507.2021.2011882 - link to the publication
  6. Antibacterial Activity of Ebselen
    Authors:
    Marta Maślanka, Artur Mucha
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 1610), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24021610 - link to the publication

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