Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of action of substances decreasing the synthesis of glycosaminoglycans in terms of their potential use in the treatment of genetically determined lysosomal storage diseases.

2011/01/B/NZ1/03686

Keywords:

metabolic diseases mucopolysaccharidoses inhibition of synthesis and accumulation of glycosaminoglycans transcriptomic profile

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_9: Biotechnology
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Gabig-Cimińska 

Number of co-investigators in the project: 5

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 406 500 PLN

Project start date (Y-m-d): 2011-12-27

Project end date (Y-m-d): 2014-12-26

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrofotometru NanoDrop-2000 Spektrofotometru NanoDrop-2000 (60 000 PLN)
  2. Inkubator z regulowaną atmosferą gazową CO2 240l (60 000 PLN)
  3. UV3/HEPA PCR Workstation (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Activity of genes controlling sphingolipid metabolism in fibroblasts treated with flavonoids
    Authors:
    Moskot, M., Chmielarz, I., Jakóbkiewicz-Banecka, J., Węgrzyn, G., Gabig-Cimińska, M.
    Academic press:
    Metabolic Brain Disease (rok: 2015, tom: 30, strony: 1257-1267), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s11011-015-9705-x - link to the publication
  2. Combined therapies for lysosomal storage diseases
    Authors:
    Gabig-Cimińska, M., Jakóbkiewicz-Banecka, J., Piotrowska, E., Malinowska, M., Kloska, A., Moskot, M., Chmielarz, I., Węgrzyn, A., Węgrzyn, G.
    Academic press:
    Current Molecular Medicine (rok: 2015, tom: 15, strony: 45317), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
    Authors:
    Moskot, M., Jakóbkiewicz-Banecka, J., Kloska, A., Malinowska, M., Rychłowski, M., Smolińska, E., Banecki, B., Węgrzyn, G., Gabig-Cimińska, M.
    Academic press:
    Scientific Reports (rok: 2015, tom: 5, strony: 9378), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1007/s11010-015-2458-3 - link to the publication
  4. The phytoestrogen genistein modulates lysosomal metabolism and transcription factor EB (TFEB) activation
    Authors:
    Moskot, M., Montefusco, S., Jakóbkiewicz-Banecka, J., Mozolewski, P., Węgrzyn, A., Bernardo, D., Węgrzyn, G., Medina, L. D., Ballabio, A., Gabig-Cimińska, M.
    Academic press:
    Journal of Biological Chemistry (rok: 2014, tom: 289, strony: 17054-17069), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M114.555300 - link to the publication
  5. Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
    Authors:
    Moskot, M., Jakóbkiewicz-Banecka, J., Smolińska, E., Piotrowska, E., Węgrzyn, G., Gabig-Cimińska, M.
    Academic press:
    Molecular and Cellular Biochemistry (rok: 2015, tom: 407, strony: 97-109), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s11010-015-2458-3 - link to the publication
  6. Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases
    Authors:
    Jakóbkiewicz-Banecka, J., Gabig-Cimińska, M., Banecka-Majkutewicz, Z., Banecki, B., Węgrzyn, A., Węgrzyn, G.
    Academic press:
    Metabolic Brain Disease (rok: 2014, tom: 29, strony: 45299), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s11011-013-9455-6 - link to the publication

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