Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Serum PAD-activity: Risk Factor in Development and Novel Biomarker in Rheumatoid Arthritis

2016/23/B/NZ5/01469

Keywords:

PAD PAD inhibitors arthritis citrullination

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Mydel 

Number of co-investigators in the project: 4

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 735 600 PLN

Project start date (Y-m-d): 2017-08-04

Project end date (Y-m-d): 2021-08-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do chromatografii AKTAStart (82 000 PLN)
  2. Specjalistyczny komputer przenośny typu laptop..

Information in the final report

  • Publication in academic press/journals (5)
  1. Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape
    Authors:
    Aliko A, Kamińska M, Bergum B, Gawron K, Benedyk M, Lamont R, Malicki S, Delaleu N, Potempa J, Mydel P
    Academic press:
    Scientific Reports (rok: 2018, tom: 8 (1), strony: NA), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-32603-y. - link to the publication
  2. Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis
    Authors:
    Kaminska M, Aliko A., Hellvard A., Bielecka E., Binder V., Marczyk A., Potempa J., Delaleu N., Kantyka T., Mydel P.
    Academic press:
    Journal of Periodontology (rok: 2018, tom: 2018;00:1–10, strony: NA), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/JPER.18-0179 - link to the publication
  3. Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis
    Authors:
    Jonsson MK, Kantyka, Falkowski K, Aliko A, Aga AB, Lillegraven S, Sexton J, Fevang BT, Mydel P, Haavardsholm EA
    Academic press:
    Scandinavian Journal of Immunology (rok: 2019, tom: Sep 23:1-9, strony: 45300), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1080/03009742.2019. - link to the publication
  4. Development of a novel, high-affinity ssDNA trypsin inhibitor
    Authors:
    Malicki S, Ksiazek M, Majewski P, Pecak A, Mydel P, Grudnik P, Dubin G
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2019, tom: 34(1):638-643, strony: 638-643), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2019.1569648 - link to the publication
  5. Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor
    Authors:
    Aliko A, Kamińska M, Falkowski K, Bielecka E, Benedyk-Machaczka M, Malicki S, Kozieł J, Wong A, Bryzek D, Kantyka T and Mydel P
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(9), 2174, strony: 20(9), 2174), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20092174 - link to the publication

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