Projects funded by the NCN
Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition
2011/01/M/NZ1/05301
Keywords:
DNA repair enzymes BER structure cystallization substrate specificity kinetics inhibitors
Descriptors:
- NZ1_4: Structural biology
- NZ1_1: Molecular biology
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Instytut Biochemii i Biofizyki PAN
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: HARMONIA 1 - announced on 2011-03-15
Amount awarded: 300 000 PLN
Project start date (Y-m-d): 2011-12-06
Project end date (Y-m-d): 2014-12-05
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Zestaw narzędzi do przechowywania i transportu krzyształów. (10 000 PLN)
- Dewar do przechowywania i transportu kryształów białek (5 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Differential repair of etheno-DNA adducts by bacterial and human AlkB proteinsAuthors:Daria Zdżalik, Anna Domańska, Paulina Prorok, Konrad Kosicki, Erwin van den Born, Päl Ø Falnes, Carmelo J Rizzo, F. Peter Guengerich, Barbara TudekAcademic press:DNA Repair (rok: 2015, tom: 30, strony: 45301), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.dnarep.2015.02.021. - link to the publication
- Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterizationAuthors:Biela A, Coste F, Culard F, Guerin M, Goffinont S, Gasteiger K, Cieśla J, Winczura A, Kazimierczuk Z, Gasparutto D, Carell T, Tudek B, Castaing B.Academic press:Nucleic Acids Research (rok: 2014, tom: 42, strony: 10748-61), Wydawca: Oxford JournalsStatus:PublishedDOI:10.1093/nar/gku613 - link to the publication