Projects funded by the NCN

Dual-acting 5-HT6/5-HT7 receptor antagonists: exploring beneficial effects for the treatment of neurodegenerative disord...

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Michał Kamiński

Uniwersytet Jagielloński

A triple agonist of glucagon, GLP-1, and GIP receptors as a novel therapeutic option for the treatment of heart failure ...

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Marta Katarzyna Oknińska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Dual Se-containing 5-HT1A and 5-HT7 biased agonists activating sigma-1 receptor as a hope of finding fast-acting antidep...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Karolina Anna Pytka

Uniwersytet Jagielloński

Semaglutide and neurodevelopment: investigating risks arising from prenatal exposure to a widely popular drug for diabet...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Agnieszka Wnuk

Instytut Farmakologii PAN

Retro-inverso modification of zinc(II)–GLP-1 receptor agonist complexes – from bioinorganic chemistry to animal studies...

Call: OPUS 26 , Panel: ST5

Principal investigator: dr hab. Magdalena Alina Rowińska-Żyrek

Uniwersytet Wrocławski, Wydział Chemii

Quiet threat or lure? Determining the function of low-amplitude signals used by birds during agonistic interactions

Call: SONATA 18 , Panel: NZ8

Principal investigator: dr Krzysztof Deoniziak

Uniwersytet w Białymstoku

Searching for natural bioactive farnesoid X receptor agonists and their role in parenteral nutrition-associated liver di...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Maciej Jan Stawny

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

The effect of chronic administration of purine P1-A2B receptor agonist, using electrospun microfibers, on intrarenal blo...

Call: PRELUDIUM 21 , Panel: NZ5

Principal investigator: Joanna Dorota Sitek-Dębska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

New approach to the treatment of Alzheimer's disease targetingresolution of inflammation and modulation of biomechanical...

Call: OPUS 22 , Panel: NZ4

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii PAN

First-in-class dual biased agonists of serotonin 5-HT1A and dopamine D2 receptors – an innovative approach in the search...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Marcin Roman Kołaczkowski

Uniwersytet Jagielloński, Collegium Medicum

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

The significance of circadian rhythm in urinary bladder cancer: deregulation of circadian genes as a putative therapeuti...

Call: OPUS 19 , Panel: NZ5

Principal investigator: prof. Edyta Wiesława Reszka

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr Natalia Eleonora Małek-Chudzik

Politechnika Wrocławska

Investigation of novel functionally selective opioid receptors agonists

Call: ETIUDA 8 , Panel: NZ7

Principal investigator: Łucja Elżbieta Szumiec

Instytut Farmakologii PAN

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

In vivo effects, underlying signaling pathways and mechanism of action of ghrelin receptor agonist against pathological ...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Piotr Chmielarz

Instytut Farmakologii PAN

Searching for the background underlying the neuroprotective effects of the specific agonist of Y2 receptors - NPY(13-36)...

Call: PRELUDIUM 17 , Panel: NZ4

Principal investigator: Łukasz Przykaza

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Marcin Marek Ratajewski

Instytut Biologii Medycznej PAN

Połączone działanie agonistów receptorów adenozynowych i antagonistów receptora P2Y12 zwiększa hamowanie funkcji płytek ...

Call: ETIUDA 7 , Panel: NZ3

Principal investigator: Nina Małgorzata Wolska

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

Rational design and evaluation of functionally biased opioid agonists

Call: OPUS 16 , Panel: NZ7

Principal investigator: prof. Ryszard Przewłocki

Instytut Farmakologii PAN

Searching for mu opioid receptor peptide agonists with G protein/beta-arrestin biased profile and their pharmacological ...

Call: SONATA 14 , Panel: ST5

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Molecular mechanism of anticancer action of selected NSAIDs as a PPAR gamma receptor agonists in experimental models of ...

Call: PRELUDIUM 14 , Panel: NZ7

Principal investigator: Adam Kazberuk

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic st...

Call: HARMONIA 9 , Panel: NZ7

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii PAN

Development of unique molecular probes: low-basicity agonists for the study of 5-HT7 receptor function

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Andrzej Jacek Bojarski

Instytut Farmakologii PAN

Investigation of the mechanisms of the neuroprotective effect of group II metabotropic receptors (mGluR2/3) agonist in a...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: dr Ewelina Małgorzata Bratek

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Katarzyna Anna Szczepańska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Molecular receptors as a tool for studies of interactions agonist/antagonist of H1 - H4 receptors

Call: PRELUDIUM 11 , Panel: ST5

Principal investigator: Małgorzata Ewa Walczak

Politechnika Łódzka, Wydział Chemiczny

Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Paweł Maria Zajdel

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Phosphorylation of the A/B domain as the crucial mechanism involved in substrate specificity of the two isoforms (RORgam...

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr Marcin Marek Ratajewski

Instytut Biologii Medycznej PAN

Search for the functionally selective 5-HT1A receptor agonists as new pharmacological tools in the development of treatm...

Call: OPUS 10 , Panel: NZ7

Principal investigator: prof. Marcin Roman Kołaczkowski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

5-HT6 receptor ligands as addition to antipsychotic therapy in schizophrenia - an impact on body weight, metabolic param...

Call: OPUS 10 , Panel: NZ7

Principal investigator: prof. Anna Małgorzata Wesołowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Metabolic profiling of HIF stabilizers, PPAR agonists and SARMs by means of UPLC-MS/MS.

Call: PRELUDIUM 9 , Panel: ST4

Principal investigator: Katarzyna Kowalczyk

Uniwersytet Warszawski, Wydział Chemii

Estrogen receptor GPER as a modulator of inflammatory and functional gastrointestinal diseases and colorectal cancer

Call: PRELUDIUM 9 , Panel: NZ5

Principal investigator: Damian Jacenik

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Maturation, pharmacogenomics, and metabolomics as factors determining pharmacokinetic and pharmacodynamics profile of al...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Paweł Wiczling

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

COX-2 inhibitors and/or PPAR agonists-conjugated PAMAM G3 dendrimers targeted into cancer cells. Biological properties a...

Call: SONATA 7 , Panel: NZ3

Principal investigator: dr Łukasz Stanisław Uram

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

Molecular mechanisms of activation and modulation of recombinant GABAA receptors by selected agonists and modulators

Call: OPUS 6 , Panel: NZ3

Principal investigator: prof. Jerzy Władysław Mozrzymas

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

Influence of antagonists (scopolamine and 3-quinuclidinyl benzilate) and agosists (carbachol) of muscarinic cholinergic ...

Call: PRELUDIUM 5 , Panel: NZ9

Principal investigator: Szymon Piotr Chowański

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Functions and costs ensuring signal reliability of so-called soft song in agonistic interactions in birds

Call: OPUS 5 , Panel: NZ8

Principal investigator: prof. Tomasz Stanisław Osiejuk

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

The influence of glucagon-like peptied-1 receptor agaonists on regulation of coticotropin-releasing hormone gene promote...

Call: PRELUDIUM 4 , Panel: NZ7

Principal investigator: Jan Stanisław Detka

Instytut Farmakologii PAN

The influence of some selected antiepileptic drugs in combination with arachinodyl-2-chlorethylamide, a selective cannab...

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr Marta Andres-Mach

Instytut Medycyny Wsi im. Witolda Chodźki

Influence of PPAR-gama receptor agonists on antitumor activity of photodynamic therapy.

Call: PRELUDIUM 3 , Panel: NZ5

Principal investigator: dr Piotr Marek Mrówka

Warszawski Uniwersytet Medyczny, Wydział Nauki o Zdrowiu

Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Jolanta Dyniewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Conjugated linoleic acid (CLA)-induced transcriptional activation of PPAR-an investigation of molecular machanisms of pu...

Call: OPUS 2 , Panel: NZ9

Principal investigator: prof. Teresa Leszczyńska

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Technologii Żywności

Partial agonists alpha1A/D-adrenoceptors as potential compounds that improve urodynamic parameters in benign prostatic h...

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr hab. Jacek Paweł Sapa

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Partial agonists of alpha-2 adrenoceptors as new perspective of the effective and safe in reducting body weight and obes...

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr Magdalena Bogumiła Dudek

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Quantitative assessment of vascular endothelial growth factor (VEGF) in serum, follicular fluid (FF) and VEGF mRNA in gr...

Call: OPUS 1 , Panel: NZ5

Principal investigator: prof. Artur Jacek Jakimiuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Concepts of Agonistic Democracy

Call: PRELUDIUM 1 , Panel: HS5

Principal investigator: Filip Biały

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Nauk Politycznych i Dziennikarstwa

Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the lig...

Call: SONATA 1 , Panel: NZ2

Principal investigator: dr Michał Koliński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Searching for alternative derivatizing agents for the trace analysis of pharmaceuticals in natural samples using gas chr...

Call: PRELUDIUM 1 , Panel: ST4

Principal investigator: dr Magda Ewa Caban

Uniwersytet Gdański