Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Rational design and evaluation of functionally biased opioid agonists

2018/31/B/NZ7/03954

Keywords:

opioid receptors biased ligands rational drug design pain side effects

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Przewłocki 

Number of co-investigators in the project: 9

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 2 495 020 PLN

Project start date (Y-m-d): 2019-07-24

Project end date (Y-m-d): 2025-07-23

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Comparison of an Addictive Potential of µ-Opioid Receptor Agonists with G Protein Bias: Behavioral and Molecular Modeling Studies
    Authors:
    Kudla L, Bugno R, Podlewska S, Szumiec L, Wiktorowska L, Bojarski AJ, Przewlocki R.
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14(1), strony: 55), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14010055 - link to the publication
  2. Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data.
    Authors:
    Podlewska, S., Bugno, R., Kudla, L., Bojarski, A. J. i Przewlocki, R.
    Academic press:
    Molecules (rok: 2020, tom: 25(20), strony: 4636), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204636 - link to the publication
  3. Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors
    Authors:
    Kudla, L. i Przewlocki, R.
    Academic press:
    Pharmacological Reports (rok: 2021, tom: 73, strony: 1033-1051), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00251-1 - link to the publication

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