Projects funded by the NCN

Identification of cytochrome P450 isoenzymes involved in the metabolism of levomepromazine in the human

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Jacek Wójcikowski

Instytut Farmakologii PAN

Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Structure optimization of inhibitor for paracaspase MALT1

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Paulina Maria Kasperkiewicz

Politechnika Wrocławska, Wydział Chemiczny

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Waldemar Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Theoretical model of SH2-dependent STAT1 dimerization as a novel tool to identify specific compounds of functional inhib...

Call: PRELUDIUM 4 , Panel: NZ2

Principal investigator: Małgorzata Szeląg

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Ewelina Marta Węglarz-Tomczak

Politechnika Wrocławska, Wydział Chemiczny

Pattern-Specific Inhibitors (PSI) - introduction and basic characteristics of a new class of inhibitors that block recog...

Call: OPUS 3 , Panel: NZ6

Principal investigator: dr Krzysztof Guzik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

Call: WEAVE-UNISONO , Panel: NZ7

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Single cell multi-omics in defining how specific oncogenic alterations shape the immune microenvironment and responses t...

Call: OPUS 20 , Panel: NZ4

Principal investigator: prof. Bożena Kamińska-Kaczmarek

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Molecular mechanisms of interplay between RORγ/RORγT receptors and cyclin-dependent kinase inhibitor (AT7519). Analysis ...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Kaja Urszula Karaś

Instytut Biologii Medycznej PAN

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Alicja Tudek

Instytut Biochemii i Biofizyki PAN

In search of specific inhibitors of myeloperoxidase, from mechanistic studies to application in enzymatic and cellular s...

Call: SONATA 14 , Panel: ST4

Principal investigator: dr Radosław Michalski

Politechnika Łódzka, Wydział Chemiczny

The significance of cancer specific PFK-II (PFKFB3 and PFKFB4) isoenzymes inhibition in overcoming resistance to BRAF in...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Sonia Elżbieta Trojan

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

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Call: SONATA 1 , Panel: NZ9

Principal investigator: dr Mariola Aleksandra Dietrich

Instytut Rozrodu Zwierząt i Badań Żywności PAN