Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification of cytochrome P450 isoenzymes involved in the metabolism of levomepromazine in the human

2011/01/B/NZ4/04859

Keywords:

levomepromazine metabolism human cytochrome P450 liver microsomes Supersomes specific inhibitors

Descriptors:

  • NZ4_16:
  • NZ4_17:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jacek Wójcikowski 

Number of co-investigators in the project: 4

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 175 860 PLN

Project start date (Y-m-d): 2011-12-15

Project end date (Y-m-d): 2013-12-14

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termostat i układ optyczny do zestawu HPLC MERCK-HITACHI (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application
    Authors:
    Wójcikowski J., Basińska A., Daniel W.A.
    Academic press:
    Biochemical Pharmacology (rok: 2014, tom: 90, strony: 188-195), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2014.05.005 - link to the publication
  2. The influence of amitriptyline and carbamazepine on levomepromazine metabolism in human liver: An in vitro study
    Authors:
    Wójcikowski J., Basińska A., Boksa J., Daniel W.A.
    Academic press:
    Pharmacological Reports (rok: 2014, tom: 66, strony: 1122-1126), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2014.07.012 - link to the publication
  1. Concentration-dependent contribution of human cytochrome P450 isoenzymes to the metabolism of levomepromazine
    Authors:
    Wójcikowski J., Basińska A., Daniel W. A.
    Conference:
    26th European College of Neuropsychopharmacology (rok: 2013, ), Wydawca: Elsevier
    Data:
    konferencja 5-9 października
    Status:
    Published
  2. The metabolism of levomepromazine by human cytochrome P450 isoenzymes.
    Authors:
    Wójcikowski J., Daniel W.A.
    Conference:
    28th CINP World Congress of Neuropsychopharmacology (rok: 2012, ), Wydawca: Cambrige Journals
    Data:
    konferencja 3-7 czerwca
    Status:
    Published
    DOI:
    link to the publication
  3. Characterization of human cytochrome P450 isoenzymes involved in the metabolism of levomepromazine
    Authors:
    Wójcikowski J., Basińska A., Daniel W. A.
    Conference:
    11th World Congress of Biological Psychiatry (rok: 2013, ), Wydawca: 11th World Congress of Biological Psychiatry
    Data:
    konferencja 23-27 czerwca
    Status:
    Published

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