Projects funded by the NCN

Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

Call: OPUS 28 , Panel: NZ6

Principal investigator: dr Renata Grzywa

Politechnika Wrocławska

Macrocyclic peptides for targeting of membrane-anchored serine protease

Call: PRELUDIUM BIS 5 , Panel: NZ7

Principal investigator: dr hab. Paulina Maria Kasperkiewicz-Wasilewska

Politechnika Wrocławska

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej PAN

Role of neutrophil serine proteases in chronic inflammatory skin diseases associated with Regnase-1 malfunction

Call: OPUS 23 , Panel: NZ6

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

The role of neutrophil serine proteases in the regulation of function of the podocyte and glomerular filtration barrier.

Call: OPUS 21 , Panel: NZ4

Principal investigator: dr hab. Agnieszka Piwkowska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Rational engineering of E. coli penicillin G acylase for quorum quenching-based bacterial control as an effective strate...

Call: PRELUDIUM 20 , Panel: NZ2

Principal investigator: dr Bartłomiej Wojciech Surpeta

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Neutrophils heterogeneity based on serine proteases

Call: SONATA BIS 10 , Panel: NZ3

Principal investigator: dr Paulina Maria Kasperkiewicz-Wasilewska

Politechnika Wrocławska

FAST interactions in cell death regulation

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Daria Martyna Dawidziak

Uniwersytet Warszawski, Wydział Chemii

SufA bacterial protease inhibitors as potential diagnostic tools and antibacterial agents.

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Ewa Magdalena Burchacka

Politechnika Wrocławska

Molecular basics of type II transmembrane serine proteases (TTSPs)-mediated activation of influenza viruses

Call: BEETHOVEN LIFE 1 , Panel: NZ1

Principal investigator: dr Paweł Zmora

Instytut Chemii Bioorganicznej PAN

Role of histone H3 serine 10 (H3S10) kinases in deregulation of transcription in diffuse large B-cell lymphoma

Call: OPUS 15 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Unnatural serine derivatives as precursors of morpholine and piperazines heterocyclic pharmacophores bearing a quaternar...

Call: PRELUDIUM 15 , Panel: ST5

Principal investigator: Aleksandra Krystyna Narczyk

Instytut Chemii Organicznej Polska Akademia Nauk

The role of mu2-adaptin serine 45 and serine 309 phosphorylation in clathrin mediated endocytosis.

Call: PRELUDIUM 13 , Panel: NZ3

Principal investigator: Aleksandra Tempes

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Insight into biochemistry, structure, evolution and biology of bacterial serpins on example of miropin from human pathog...

Call: OPUS 9 , Panel: NZ1

Principal investigator: dr Mirosław Książek

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Analysis of selected physicochemical, biological and pharmacological properties of biomedical materials modified by synt...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: dr Katarzyna Szałapata

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Selective activity based probes for imaging of active serine proteases in neutrophils.

Call: HARMONIA 6 , Panel: ST5

Principal investigator: dr hab. Marcin Drąg

Politechnika Wrocławska, Wydział Chemiczny

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Elżbieta Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Chemical sensors for selective determination of chosen amino acids of gluten proteins using molecularly imprinted polyme...

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Zofia Ewa Iskierko

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Maciej Sławomir Walczak

Politechnika Wrocławska, Wydział Chemiczny

Design and synthesis of selective and irreversible inhibitors of HAT protease.

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Marcin Skoreński

Politechnika Wrocławska, Wydział Chemiczny

Phosphonic inhibitors of human neutrophil elastase in cancer therapy

Call: SONATA 5 , Panel: NZ4

Principal investigator: dr Łukasz Winiarski

Politechnika Wrocławska, Wydział Chemiczny

Role of the gene KEX2 in Candida albicans Virulence

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Monika Staniszewska

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

Tannerella forsythia: regulation of intra- and extracellular proteolytic activity in pathogenicity mechanism.

Call: PRELUDIUM 2 , Panel: NZ1

Principal investigator: Mirosław Książek

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Inhibitors of serine proteases as regulators of dendritic cell function.

Call: MAESTRO 1 , Panel: NZ5

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

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Call: SONATA 1 , Panel: NZ9

Principal investigator: dr Mariola Aleksandra Dietrich

Instytut Rozrodu Zwierząt i Badań Żywności PAN

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Waldemar Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii