Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of the gene KEX2 in Candida albicans Virulence

2011/03/D/NZ7/06198

Keywords:

Candida albicans virulence morphotypes asparic proteinase serine proteinase reconstituted human epithelia colonisation adhesion invasion immune response

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Monika Staniszewska 

Number of co-investigators in the project: 3

Call: SONATA 2 - announced on 2011-09-15

Amount awarded: 379 070 PLN

Project start date (Y-m-d): 2012-08-14

Project end date (Y-m-d): 2016-06-13

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. LightCycler 96 firmy Roche Diagnostics Polska Sp. z o. o..
  2. wirówka 5430R firmy Eppendorf z wyposażeniem (27 000 PLN)
  3. komora laminarna (50 000 PLN)
  4. mikroskop odwrócony (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (18)
  • Articles in post-conference publications (1)
  1. Lipase-Catalyzed Kinetic Resolution of Novel Antifungal N-Substituted Benzimidazole Derivatives
    Authors:
    Łukowska-Chojnacka E., Staniszewska M., Bondaryk M., Maurin JK., Bretner M.
    Academic press:
    Chirality (rok: 2016, tom: brak, strony: brak), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/chir.22591 - link to the publication
  2. Sulfone derivatives reduce growth, adhesion and aspartic protease SAP2 gene expression
    Authors:
    Małgorzata Bondaryk, Zbigniew Ochal, Monika Staniszewska
    Academic press:
    World Journal of Microbiology and Biotechnology (rok: 2014, tom: 30, strony: 2511-2521), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11274-014-1676-2 - link to the publication
  3. Antifungal agents commonly used in the superficial and mucosal candidiasis treatment: mode of action and resistance development
    Authors:
    Małgorzata Bondaryk, Wiesław Kurzątkowski, and Monika Staniszewska
    Academic press:
    Advances in Dermatology and Allergology (rok: 2013, tom: 30, strony: 293–301), Wydawca: Termedia Publishing
    Status:
    Published
    DOI:
    10.5114/pdia.2013.38358 - link to the publication
  4. Quantitative Expression of Candida albicans Aspartyl Proteinase Genes SAP7,SAP8,SAP9,SAP10 in Human Serum in vitro
    Authors:
    MONIKA STANISZEWSKA, MAŁGORZATA BONDARYK, TADEUSZ MALEWSKI, WIESŁAW kURZĄTKOWSKI
    Academic press:
    Polish Journal of Microbiology (rok: 2014, tom: 63, strony: 15-20), Wydawca: Polskie Towarzystwo Mikrobiologów
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Susceptibility of Candida albicans to new synthetic sulfone derivatives
    Authors:
    Monika Staniszewska, Małgorzata Bondaryk, Zbigniew Ochal
    Academic press:
    Arch Pharm Life Sci (rok: 2015, tom: 348, strony: 132-143), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/ardp.201400360 - link to the publication
  6. The in Vitro Effects of New D186 Dendrimer on Virulence Factors of Candida albicans
    Authors:
    Monika Staniszewska, Małgorzata Bondaryk, Paulina Zielinska, Zofia Urbanczyk-Lipkowska
    Academic press:
    The Journal of Antibiotics (rok: 2014, tom: 67, strony: 425-432), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/ja.2014.25 - link to the publication
  7. Antifungal Effect of Novel 2-bromo-2-chloro- 2-(4-chlorophenylsulfonyl)-1-phenylethanone against Candida strains
    Authors:
    Monika Staniszewska, Małgorzata Bondaryk, Magdalena Wieczorek, Eine Estrada- Mata, Hector M. Mora Montes, Zbigniew Ochal
    Academic press:
    Frontiers in Microbiology (rok: 2016, tom: 7, strony: 1309-), Wydawca: Frontiers Media SA
    Status:
    Accepted for publication
    DOI:
    10.3389/fmicb.2016.01309 - link to the publication
  8. Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers (
    Authors:
    Zielińska P., Staniszewska M., Bondaryk M., Urbańczyk-Lipkowska Z
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2015, tom: 105, strony: 106-119), Wydawca: Elsevier Masson SAS
    Status:
    Published
    DOI:
    10.1186/1423-0127-20-101 - link to the publication
  9. New synthetic sulfone derivatives inhibit growth, adhesion and the leucine arylamidase APE2 gene expression in Candida albicans in vitro
    Authors:
    Monika Staniszewska, Małgorzata Bondaryk, Zbigniew Ochal
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2015, tom: 23, strony: 314-321), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2014.11.038 - link to the publication
  10. The expression of the Candida albicans gene SAP4 during hyphal formation in human serum and in adhesion to monolayer cell culture of colorectal carcinoma Caco-2 (ATCC)
    Authors:
    Staniszewska Monika, Bondaryk Małgorzata, Malewski Tadeusz, Schaller Martin
    Academic press:
    Central European Journal of Biology (rok: 2014, tom: 9, strony: 798-810), Wydawca: Versita, co-published with Springer Verlag
    Status:
    Published
    DOI:
    10.2478/s11535-014-0311-4 - link to the publication
  11. Comparison of anti-Candida albicans activities of halogenomethylsulfonyl derivatives
    Authors:
    Małgorzata Bondaryk, Zbigniew Ochal, Monika Staniszewska
    Academic press:
    Med Chem Res (rok: 2014, tom: brak, strony: brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00044-014-1258-8 - link to the publication
  12. The in vitro expression of SAP6 gene in Candida albicans morphogenesis mutants under human serum influence
    Authors:
    Staniszewska Monika, Bondaryk Małgorzata, Malewski Tadeusz, Kurzątkowski Wiesław
    Academic press:
    Biologia (rok: 2013, tom: 68, strony: 803-807), Wydawca: Versita, co-published with Springer Verlag
    Status:
    Published
    DOI:
    10.2478/s11756-013-0226-y - link to the publication
  13. The effect of the serine protease KEX2 on Candida albicans virulence under halogenated methyl sulfones
    Authors:
    Monika Staniszewska, Małgorzata Bondaryk, Michalina Kazek, Aleksandra Gliniewicz, Christina Braunsdorf, Martin Schaller, Hector M. Mora-Montes, and Zbigniew Ochal,
    Academic press:
    Future Microbiology (tom: brak, strony: brak), Wydawca: Future Science Group
    Status:
    Submitted
    DOI:
    brak - link to the publication
  14. Pathogenesis and treatment of fungal infections by Candida albicans
    Authors:
    Staniszewska Monika, Bondaryk Małgorzata, Kowalska Marzena, Magda Urszula, Łuka Martyna, Ochal Zbigniew, Kurzątkowski Wiesław
    Academic press:
    Postępy Mikrobiologii (rok: 2014, tom: 53, strony: 229-240), Wydawca: Polskie Towarzystwo Mikrobiologów
    Status:
    Published
    DOI:
    brak - link to the publication
  15. Possible Role of Hydrolytic Enzymes (Sap, Kex2) in C. albicans Response to Aromatic Compounds Bearing Sulfone Moiety
    Authors:
    Bondaryk M., Grabowska-Jadach I., Sygitowicz G., Ochal Z., Staniszewska M.
    Academic press:
    Chemical Papers (rok: 2016, tom: 70, strony: 1336-1350), Wydawca: De Gruyter Publisher
    Status:
    Published
    DOI:
    10.1515/chempap-2016-0072 - link to the publication
  16. Role of SAP7-10 and Morphological Regulators (EFG1, CPH1) in Candida albicans' Hypha Formation and Adhesion to Colorectal Carcinoma Caco-2
    Authors:
    Monika Staniszewska, Małgorzata Bondaryk, Kamil Żukowski, Michał Chudy
    Academic press:
    Polish Journal of Microbiology (rok: 2015, tom: 64, strony: 203-210), Wydawca: Polskie Towarzystwo Mikrobiologów
    Status:
    Published
    DOI:
    brak - link to the publication
  17. Tetrazole activity against Candida albicans. the role of KEX2 mutations in the sensitivity to (±)-1-[5-(2-chlorophenyl)-2H-tetrazol-2-yl]propan-2-yl acetate
    Authors:
    Bondaryk, M., Łukowska-Chojnacka, E., Staniszewska, M.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2015, tom: 25, strony: 2657-2663), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.bmcl2015.04.078 - link to the publication
  18. Contribution of Aspartic Proteases in Candida Virulence. Protease Inhibitors against Candida Infections
    Authors:
    Staniszewska M., Bondaryk M., Ochal Z.
    Academic press:
    Current Protein & Peptide Science (rok: 2016, tom: brak, strony: brak), Wydawca: Bentham Science Publisher LTD
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  1. IN VITRO EXPRESSION OF CANDIDA ALBICANS SAP1-10 GENES IN THE INTESTINAL CANDIDIASIS MODEL
    Authors:
    Bondaryk Małgorzata, Staniszewska Monika
    Conference:
    the 31st Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID 2013), Milan, Italy, (rok: 2013, ), Wydawca: ESPID
    Data:
    konferencja Maj 28 -Czerwiec 1,
    Status:
    Published
    DOI:
    link to the publication

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