Projects funded by the NCN

NMR Spectroscopy as Molecular Language: A Deep Learning Approach to Bioactivity Prediction

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Arkadiusz Bogumił Leniak

Instytut Farmakologii PAN

First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Maria Kucwaj-Brysz

Uniwersytet Jagielloński, Collegium Medicum

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Quinoxalino-2,3-diones as potent tools for exploration of ionotropic kainate receptors

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Ewa Monika Szymańska

Uniwersytet Jagielloński, Collegium Medicum

New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: dr Przemysław Patryk Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Extension of the CABS-dock method for protein-peptide docking to modelling of membrane proteins

Call: PRELUDIUM 15 , Panel: NZ1

Principal investigator: Maciej Paweł Ciemny

Uniwersytet Warszawski, Wydział Chemii

Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

Call: PRELUDIUM 12 , Panel: NZ1

Principal investigator: Jakub Jakub Jakowiecki

Uniwersytet Warszawski, Wydział Chemii

Development of an NK1 receptor homology model based on the data concerning interspecies differences in ligand binding.

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr Piotr Jakub Lipiński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

An immunoassay combined with chromatography followed by multivariate receptor modelling techniques for source tracking o...

Call: PRELUDIUM 12 , Panel: ST10

Principal investigator: Marta Ewelina Kobusińska

Uniwersytet Gdański, Wydział Oceanografii i Geografii

Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Katarzyna Anna Szczepańska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Molecular mechanism of interactions between GPCRs and G protein.

Call: PRELUDIUM 10 , Panel: NZ2

Principal investigator: Stefan Mateusz Mordalski

Instytut Farmakologii PAN

A virtual screening protocol based on automatically generated structure-based pharmacophore models.

Call: HARMONIA 7 , Panel: NZ2

Principal investigator: Stefan Mateusz Mordalski

Instytut Farmakologii PAN

Amine derivatives of hydantoin as selective 5-HT7 receptor ligand. Molecular modeling, synthesis and pharmacological eva...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Katarzyna Maria Kucwaj-Brysz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum Uniwersytet Jagielloński; Wydział Farmaceutyczny

The new homology model of H3 histaminic receptor - structure, interaction with ligand

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Jakub Józef Jończyk

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Fentanyl opioid designer drugs: from molecular modeling to in vitro studies

Call: OPUS 6 , Panel: ST4

Principal investigator: prof. Joanna Sadlej

Narodowy Instytut Leków

The mechanism of ligand binding and the conformational changes in the beta2-adrenergic receptor molecule

Call: SONATA 5 , Panel: NZ2

Principal investigator: dr Anita Płazińska

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Formation of spatial heterogeneities on the plama membrane and their impact on cell signaling

Call: PRELUDIUM 5 , Panel: NZ2

Principal investigator: Marek Kochańczyk

Instytut Podstawowych Problemów Techniki Polska Akademia Nauk

Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

Call: SONATA 4 , Panel: NZ1

Principal investigator: dr Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Search for new "drug-like" molecules designed as adenosine receptors ligands

Call: HARMONIA 2 , Panel: NZ4

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

In vitro and in vivo investigations of the radiometals influence on the ability of CCK2R receptors imaging by the radiol...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Renata Radosława Mikołajczak

Narodowe Centrum Badań Jądrowych

Source apportionment of severe particulate matter air pollution events in selected Polish cities

Call: OPUS 2 , Panel: ST10

Principal investigator: dr hab. Katarzyna Krystyna Juda-Rezler

Politechnika Warszawska, Wydział Inżynierii Środowiska

Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the lig...

Call: SONATA 1 , Panel: NZ2

Principal investigator: dr Michał Koliński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN