Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Formation of spatial heterogeneities on the plama membrane and their impact on cell signaling

2013/09/N/NZ2/02631

Keywords:

membrane proteins receptor clustering diffusion-limited reaction kinetics rule-based modeling stochastic simulations

Descriptors:

  • NZ2_10: Biological systems analysis, modelling and simulation
  • NZ3_7: Signal transduction
  • ST6_12: Scientific computing, simulation and modelling tools

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Podstawowych Problemów Techniki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Marek Kochańczyk 

Number of co-investigators in the project: 3

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 93 600 PLN

Project start date (Y-m-d): 2014-05-05

Project end date (Y-m-d): 2017-03-04

Project duration:: 34 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  1. Effective reaction rates for diffusion-limited reaction cycles
    Authors:
    Paweł Nałęcz-Jawecki, Paulina Szymańska, Marek Kochańczyk, Jacek Miękisz, Tomasz Lipniacki
    Academic press:
    Journal of Chemical Physics (rok: 2015, tom: 143, strony: 215102), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4936131 - link to the publication
  2. Effective reaction rates in diffusion-limited phosphorylation–dephosphorylation cycles
    Authors:
    Paulina Szymańska, Marek Kochańczyk, Jacek Miększ, Tomasz Lipniacki
    Academic press:
    Physical Review E (rok: 2015, tom: 91, strony: 22702), Wydawca: American Physical Society
    Status:
    Published
    DOI:
    10.1103/PhysRevE.91.022702 - link to the publication
  3. SPATKIN: a simulator for spatial rule-based modeling of biomolecular site dynamics
    Authors:
    Marek Kochańczyk, William S. Hlavacek, Tomasz Lipniacki
    Academic press:
    Bioinformatics (rok: 2017, tom: 33, strony: 3667–3669), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/bioinformatics/btx456 - link to the publication
  4. Relaxation oscillations and hierarchy of feedbacks in MAPK signaling
    Authors:
    Marek Kochańczyk, Paweł Kocieniewski, Emilia Kozłowska, Joanna Jaruszewicz-Błońska, Breanne Sparta Michael Pargett, John G. Albeck, William S. Hlavacek, Tomasz Lipniacki
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 38244), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep38244 - link to the publication

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