Projects funded by the NCN

Synthesis and study of anticancer activities and affinities to kinesin of selected sandwich and half-sandwich organometa...

Call: OPUS 9 , Panel: ST5

Principal investigator: dr hab. Damian Plażuk

Uniwersytet Łódzki, Wydział Chemii

New MOF compounds as degradable nanocontainers of tyrosine kinases inhibitors in novel anti-cancer therapy

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Artur Terzyk

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Maria Bretner

Politechnika Warszawska, Wydział Chemiczny

Modification of cellular aging in vitro by inhibitors of non-enzymatic protein modifications

Call: OPUS 9 , Panel: NZ3

Principal investigator: prof. Grzegorz Bartosz

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

In vivo and in vitro structure of influenza virus RNA. The structural determinants behind the inhibition of influenza vi...

Call: OPUS 10 , Panel: NZ1

Principal investigator: prof. Elżbieta Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Tick-borne encephalitis virus - search for mechanisms useful in treatment and prophylaxis.

Call: SONATA 10 , Panel: NZ6

Principal investigator: dr hab. Ewelina Król

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Dynamic Relation between Repetitive Negative Thinking and Inhibition in Depression - Daily Process Approach

Call: POLONEZ 2 , Panel: HS6

Principal investigator: dr Monika Kornacka

SWPS Uniwersytet Humanistycznospołeczny w Warszawie, Wydział Psychologii

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the primary open-angle glaucoma treatmen...

Call: OPUS 11 , Panel: NZ5

Principal investigator: prof. Ireneusz Majsterek

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Molecular aspects of interference with the thymidylate synthase-catalyzed reaction mechanism by the slow-binding inhibit...

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Wojciech Rode

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

Structure and function characterization of newly discovered unique inhibitors of proteases

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Synthesis and biological evaluation of novel, drug-like multifunctional ligands, as potential anti-Alzheimer's agents ta...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Dawid Panek

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Paweł Zajdel

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Spectroscopic studies in micro- and nanoscale of the corrosion process and its inhibition of the modified metallic surfa...

Call: SONATA 15 , Panel: ST4

Principal investigator: dr Dominika Maria Święch

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Akademickie Centrum Materiałów i Nanotechnologii AGH

SufA bacterial protease inhibitors as potential diagnostic tools and antibacterial agents.

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Ewa Magdalena Burchacka

Politechnika Wrocławska

Dual CBR1-AKR1C3 inhibitors as a new approach to improve effectiveness and safety of anthracycline therapy.

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Marek Andrzej Jamrozik

Uniwersytet Jagielloński, Collegium Medicum

Structure optimization of the PD-1/PD-L1 inhibitors based on the terphenyl scaffold

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: dr Damian Muszak

Uniwersytet Jagielloński, Wydział Chemii

Role of cereal leaf beetle – associated bacteria in the adaptation of their insect host to the insecticides and protease...

Call: PRELUDIUM 19 , Panel: NZ9

Principal investigator: Beata Wielkopolan

Instytut Ochrony Roślin - Państwowy Instytut Badawczy

The influence of natural plant extracts obtained by supercritical extraction on the replication inhibition of the most i...

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Grzegorz Jan Woźniakowski

Uniwersytet Mikołaja Kopernika w Toruniu

A novel approach based on the optimized multidrug combination for glioblastoma treatment.

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Kucińska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Iron chelators as tyrosine kinase inhibitors - a new strategy for the treatment of glioblastoma multiforme

Call: PRELUDIUM BIS 2 , Panel: NZ5

Principal investigator: dr hab. Anna Dominika Mrozek-Wilczkiewicz

Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

Call: WEAVE-UNISONO , Panel: NZ7

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Maria Żarnik

Uniwersytet Jagielloński, Wydział Chemii

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

An influence of lipoproteins on fibrinolysis and pleiotropic effect of proprotein convertase subtilisin/kexin type 9 (PC...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Magdalena Teresa Kopytek

Krakowski Szpital Specjalistyczny im. Jana Pawła II

The role of glycosylation of structural proteins in the life cycle of SARS-CoV-2 coronavirus.

Call: OPUS 21 , Panel: NZ6

Principal investigator: dr hab. Ewelina Król

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Novel combination therapies of pulmonary arterial hypertension targeting blockade of peripheral cannabinoid CB1 receptor...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Barbara Malinowska

Uniwersytet Medyczny w Białymstoku

Lipidic liquid-crystalline nanomaterials for reconstitution and physico-chemical studies of membrane proteins

Call: OPUS 22 , Panel: ST4

Principal investigator: prof. Renata Bilewicz

Uniwersytet Warszawski, Wydział Chemii

Combinatorial targeting of non-genetic sources of cell-to-cell heterogeneity to overcome fractional killing of cancer ce...

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Jarosław Walczak

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

Call: PRELUDIUM BIS 3 , Panel: ST4

Principal investigator: dr hab. Katarzyna Magdalena Błażewska

Politechnika Łódzka, Wydział Chemiczny

The effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on changes in selected epigenetic mechan...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Agnieszka Magdalena Woźniak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

Call: OPUS 23 , Panel: NZ5

Principal investigator: dr hab. Urszula Mackiewicz

Centrum Medyczne Kształcenia Podyplomowego

The role of diet in the development of autoimmune diseases - new interleukin 15 inhibitors among dietary polyphenols and...

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Barbara Joanna Żyżyńska-Granica

Warszawski Uniwersytet Medyczny

Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Dorota Suszczyk

Uniwersytet Medyczny w Lublinie

The effect of Tcf7l2 knockout on excitation/inhibition balance in neuronal circuits of the thalamus

Call: PRELUDIUM 22 , Panel: NZ3

Principal investigator: Katarzyna Hryniewiecka

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Alicja Potok

Uniwersytet Wrocławski, Wydział Chemii

Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Magdalena Stobiecka

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

Call: OPUS 25 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr Bartosz Pomierny

Uniwersytet Jagielloński, Collegium Medicum

Early Intervention with mTOR Inhibitors for Neuropsychiatric Symptoms in Tuberous Sclerosis Complex: Unveiling Developme...

Call: DAINA 3 , Panel: NZ4

Principal investigator: prof. Ewelina Knapska

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Controlling the covalent activity of a PD-L1 inhibitors with light

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Wiktor Uzar

Uniwersytet Jagielloński w Krakowie

Development of novel screening method for identifying xanthine oxidase inhibitors – towards new drug candidates for gout...

Call: PRELUDIUM 23 , Panel: ST4

Principal investigator: Monika Rola

Politechnika Łódzka

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Helbik-Maciejewska

Uniwersytet Gdański

The expression of complement inhibitors in ovarian and corpus uteri cancers - a new perspective for immunotherapy

Call: SONATA 1 , Panel: NZ7

Principal investigator: dr hab. Lucyna Kapka-Skrzypczak

Wyższa Szkoła Informatyki i Zarządzania w Rzeszowie, Wydział Turystyki i Nauk o Zdrowiu

Identification of cytochrome P450 isoenzymes involved in the metabolism of levomepromazine in the human

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Jacek Wójcikowski

Instytut Farmakologii PAN

Identification and characterization of specific carp (Cyprinu carpio L) seminal plasma proteins – proteomics and classic...

Call: SONATA 1 , Panel: NZ9

Principal investigator: dr Mariola Dietrich

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy...

Call: OPUS 1 , Panel: NZ6

Principal investigator: prof. Wojciech Rode

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Defining the brain structures involved in delf-exposure (exploratory behavior) and partial inhibition of these structure...

Call: PRELUDIUM 1 , Panel: HS6

Principal investigator: Ita Robakiewicz

Wyższa Szkoła Finansów i Zarządzania w Warszawie

Function of DNA methylation and CNV-type polymorphisms of genes encoding metalloproteinase and their tissue inhibitors i...

Call: OPUS 2 , Panel: NZ5

Principal investigator: dr Edyta Majorczyk

Politechnika Opolska, Wydział Wychowania Fizycznego i Fizjoterapii

Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: developm...

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum