Projects funded by the NCN
A novel approach based on the optimized multidrug combination for glioblastoma treatment.
2020/39/D/NZ7/00789
Keywords:
glioblastoma multiforme inhibitors of receptor tyrosine kinases 3D cell culture CAM model orthotopic xenograft model drug repurposing
Descriptors:
- NZ7_014:
- NZ5_007:
- NZ7_015:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
woj. wielkopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 6
Call: SONATA 16 - announced on 2020-09-15
Amount awarded: 1 726 935 PLN
Project start date (Y-m-d): 2021-06-15
Project end date (Y-m-d): 2025-06-14
Project duration:: 48 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their SecretsAuthors:Julia Pospieszna, Hanna Dams-Kozlowska, Wachirawit Udomsak, Marek Murias, Malgorzata KucinskaAcademic press:International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 10910), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms241310910 - link to the publication
- Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their SecretsAuthors:Julia Pospieszna, Hanna Dams-Kozlowska, Wachirawit Udomsak, Marek Murias, Malgorzata KucinskaAcademic press:International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 10910), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms241310910 - link to the publication
- The combination therapy using tyrosine kinase receptors inhibitors and repurposed drugs to target patient-derived glioblastoma stem cellsAuthors:Malgorzata Kucinska,, Julia Pospieszna, Jing Tang, Natalia Lisiak, Ewa Toton, Blazej Rubis, Marek MuriasAcademic press:Biomedicine and Pharmacotherapy (rok: 2024, tom: 176, strony: 116892), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.biopha.2024.116892 - link to the publication