Projects funded by the NCN
Heterocyclization of benzenoid ansamycins core as useful strategy for designing anticancer agents
2021/41/N/ST4/02137
Keywords:
ansamycins benzo[d]oxazoles macrolactams anticancer agents Hsp90 inhibitors atropisomerization heterocyclization
Descriptors:
- ST4_008:
- ST4_009:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii
woj. wielkopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 20 - announced on 2021-03-15
Amount awarded: 69 979 PLN
Project start date (Y-m-d): 2022-01-18
Project end date (Y-m-d): 2023-01-17
Project duration:: 12 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- New cascade heterocyclization strategy of the benzoquinone core of ansamycin antibiotic into benzoxazole derivatives and their anticancer potencyAuthors:N. Skrzypczak, K. Pyta, W. Bohusz, A. Leśniewska, M. Gdaniec, P. Ruszkowski, W. Schilf, F. Bartl, P. PrzybylskiAcademic press:The Journal of Organic Chemistry (), Wydawca: ACSStatus:PublishedDOI:10.1021/acs.joc.3c00493?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as - link to the publication
- Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicityAuthors:N. Skrzypczak, A. Buczkowski, W. Bohusz, E. Nowak, K. Tokarska, A. Leśniewska, A. M. Alzebari, P. Ruszkowski, M. Gdaniec, F. Bartl, P. PrzybylskiAcademic press:European Journal of Medicinal Chemistry , Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2023.115450 - link to the publication