Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Molecular determinants of input specificity in plasticity phenomena at GABAergic synapses in the hippocampus

2021/43/B/NZ4/01675

Keywords:

synaptic plasticity GABA interneuron inhibitory synaptic transmission learning memory

Descriptors:

  • NZ4_007:
  • NZ4_009:
  • NZ3_006:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Władysław Mozrzymas 

Number of co-investigators in the project: 7

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 2 843 400 PLN

Project start date (Y-m-d): 2022-09-02

Project end date (Y-m-d): 2027-09-01

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. NMDA-Dependent Coplasticity in VIP Interneuron-Driven Inhibitory Circuits
    Authors:
    Jadwiga Jabłońska, Grzegorz Wiera, Jerzy W. Mozrzymas
    Academic press:
    Journal if Neurochemistry (rok: 2025, tom: Volume169, strony: Volume169, Issue6), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1111/jnc.70117 - link to the publication
  2. D1-type dopamine receptors are critical for GABAergic synaptic plasticity in CA1 mouse hippocampal SST interneurons and pyramidal cells
    Authors:
    Patrycja Brzdąk , Katarzyna Lebida , Patrycja Droździel , Emilia Stefańczyk , Aleksandra Leszczyńska , Jerzy W. Mozrzymas
    Academic press:
    Progress in Neurobiology (rok: 2025, tom: Volume 255, strony: Volume 255, December 2025, 102845), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.pneurobio.2025.102845 - link to the publication
  3. Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus
    Authors:
    Jadwiga Jabłońska 1 , Grzegorz Wiera 1 , Jerzy W. Mozrzymas
    Academic press:
    Matrix Biology (rok: 2024, tom: Volume 134, strony: 184-196), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.matbio.2024.11.001 - link to the publication
  4. Input specificity of NMDA-dependent GABAergic plasticity in the hippocampus
    Authors:
    Grzegorz Wiera, Jadwiga Jabłońska, Anna Maria Lech & Jerzy W. Mozrzymas
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: Article number: 20463 (2024)), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-70278-w - link to the publication
  5. GABAergic synapses onto SST and PV interneurons in the CA1 hippocampal region show cell‑specifc and integrin‑dependent plasticit
    Authors:
    J. Mozrzymas, K. Lebida, P. Brzdąk, M. Wyroślak
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 5079), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-023-31882-4 - link to the publication
  6. Molecular mechanisms of the GABA type A receptor function
    Authors:
    Michał A. Michałowski Open the ORCID record for Michał A. Michałowski, Karol Kłopotowski , Grzegorz Wiera , Marta M. Czyżewska, Jerzy W. Mozrzymas
    Academic press:
    Quarterly Reviews of Biophysics (rok: 2025, tom: Volume 58, strony: Volume 58 , 2025 , e3), Wydawca: Published online by Cambridge University Press
    Status:
    Published
    DOI:
    10.1017/S0033583524000179 - link to the publication

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