Projects funded by the NCN

Targeting enzymes of the parasite's purine salvage pathway as a new approach to combat H. pylori infections, including t...

Call: OPUS 26 , Panel: NZ1

Principal investigator: prof. Maria Agnieszka Bzowska

Uniwersytet Warszawski, Wydział Fizyki

Modified (oligo)nucleotides for photo-controlled manipulation of mRNA

Call: SONATA 18 , Panel: ST4

Principal investigator: dr Marcin Warmiński

Uniwersytet Warszawski, Wydział Fizyki

Novel pathway of vitamin B12 activation by CD73 - analysis of molecular mechanisms, in vivo processing and clinical rele...

Call: SONATA 17 , Panel: NZ4

Principal investigator: dr hab. Marta Urszula Tomczyk

Gdański Uniwersytet Medyczny, Wydział Lekarski

Radiosensitization by the combined use of modified nucleosides and inhibitors of DNA repair to improve the efficacy of r...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Magdalena Danuta Zdrowowicz-Żamojć

Uniwersytet Gdański, Wydział Chemii

Synthesis and structural/biophysical studies of model mRNA/mt-tRNA oligomers to evaluate the role of modified nucleoside...

Call: OPUS 22 , Panel: ST4

Principal investigator: dr hab. Grażyna Bożena Leszczyńska

Politechnika Łódzka

Chemical architecture of fluorinated nucleoside dimers containing 1,2,3-triazole linker of potential use in molecular bi...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Dagmara Baraniak

Instytut Chemii Bioorganicznej PAN

Fotochemistry and Photophysics of Thiated Prebiotic Precursors of Nucleotides

Call: PRELUDIUM 17 , Panel: ST4

Principal investigator: dr Mikołaj Jan Janicki

Politechnika Wrocławska

Application of targeted metabolomic approach in quantitative prospective analysis of nucleosides profiles alterations be...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: Małgorzata Artymowicz

Gdański Uniwersytet Medyczny

Why Nature introduced selenium to wobble nucleosides in transfer RNA?

Call: OPUS 15 , Panel: ST5

Principal investigator: prof. Barbara Czesława Nawrot

Centrum Badań Molekularnych i Makromolekularnych PAN

Purinergic signaling as important regulator of hematopoietic system

Call: OPUS 15 , Panel: NZ4

Principal investigator: prof. Mariusz Zdzisław Ratajczak

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Functional glycol nucleic acid (fun-GNA) nucleosides, nucleotides and oligos: synthesis and properties

Call: OPUS 15 , Panel: ST5

Principal investigator: prof. Konrad Maciej Kowalski

Uniwersytet Łódzki, Wydział Chemii

The influence of impairment of extracellular nucleoside and nucleotide signaling on synaptic structure and function in a...

Call: OPUS 13 , Panel: NZ4

Principal investigator: dr hab. Agata Adamczyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered...

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Elżbieta Jadwiga Sochacka

Politechnika Łódzka, Wydział Chemiczny

Investigating the biological role of 5' nucleotidases cN-IIIA and cN-IIIB in mRNA degradation and their terapeutic signi...

Call: SONATINA 1 , Panel: NZ1

Principal investigator: dr Dorota Maria Kubacka

Uniwersytet Warszawski, Wydział Fizyki

Adaptations of cardiac myocyte energy metabolism in atherosclerosis - implications for pathology and therapeutic strateg...

Call: OPUS 12 , Panel: NZ4

Principal investigator: dr hab. Ryszard Tomasz Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

Application of LCMS to quantitative analysis of composition of in vitro transcribed RNAs containing chemically modified ...

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Dominika Strzelecka

Uniwersytet Warszawski, Wydział Fizyki

N-Oxide phosphobetaines in new synthetic strategies for P-modified phosphates and polyphospates of natural biomolecules ...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Magdalena Materna

Instytut Chemii Bioorganicznej PAN

Reversal of heart failure during mechanical support of left ventricular function - role of nucleotides and energetics in...

Call: HARMONIA 8 , Panel: NZ4

Principal investigator: dr hab. Ryszard Tomasz Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

Fluorescent biosensors based on quantum dots and purines/pyrimidines - synthesis, characterization and potential applica...

Call: PRELUDIUM 11 , Panel: ST5

Principal investigator: Łucja Anna Rodzik-Czałka

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Pro-nucleotides based on mRNA cap structure - synthesis, biological and biophysical evaluation

Call: SONATA 11 , Panel: ST5

Principal investigator: dr Karolina Ewa Piecyk

Uniwersytet Warszawski, Wydział Chemii

Mitochondrial nucleoside diphosphate kinase (NDPK) as a regulator of mitochondrial proton leak catalyzed by purine nucle...

Call: SONATA 10 , Panel: NZ3

Principal investigator: dr Andrzej Marek Woyda-Płoszczyca

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Purine salvage pathway enzymes as a target for pathogenic organisma lacking de novo purine synthesis -cas study of Helic...

Call: HARMONIA 7 , Panel: NZ1

Principal investigator: prof. Maria Agnieszka Bzowska

Uniwersytet Warszawski, Wydział Fizyki

Synthesis and evaluation of a novel toolkit for biology and biotechnology based on adenine nucleotides analogs

Call: SONATA BIS 5 , Panel: ST5

Principal investigator: dr hab. Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Look at the mechanism of ovarian cancer cells response to adenine nucleosides modified with metallacarborane clusters wi...

Call: OPUS 9 , Panel: NZ3

Principal investigator: dr Katarzyna Bednarska

Instytut Biologii Medycznej PAN

New nucleotide analogs containing triazole within oligophosphate bridge as mimics of the 5' end of mRNA - synthesis, pro...

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Sylwia Ciechanowicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

From a molecular in silico model to cellular response in vitro. Modified nucleosides as photo and/or radiosensitizers of...

Call: MAESTRO 6 , Panel: ST4

Principal investigator: prof. Janusz Adam Rak

Uniwersytet Gdański, Wydział Chemii

THE EFFECT OF NUCLEOSIDE ANALOGUES ON REPLICATION OF CYHV-3 (CYPRINID HERPESVIRUS 3) IN CELL LINES OF COMMON CARP (CYPRI...

Call: PRELUDIUM 7 , Panel: NZ6

Principal investigator: Agnieszka Dorota Troszok

Polska Akademia Nauk

Studies on the synthesis of newly discovered cyclic N6-threonylcarbamoyladenosine (ct6A) and its analogues and on the in...

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Michał Robert Matuszewski

Politechnika Łódzka, Wydział Chemiczny

Metabolic profiles, gene polymorphism in NAT2, GSTM1, GSTP1, CYP1A1, COMT and epidemiological data in a holistic approac...

Call: PRELUDIUM 7 , Panel: NZ7

Principal investigator: Emilia Leila Daghir-Wojtkowiak

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Biosynthesis of seleno-modified nucleosides in the anticodon loop of transfer ribonucleic acids. Evaluation of the enzym...

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Barbara Czesława Nawrot

Centrum Badań Molekularnych i Makromolekularnych PAN

Cellular and molecular mechanism of action of PPI dendrimer complexes with nucleoside analogue anticancer drugs

Call: OPUS 7 , Panel: NZ3

Principal investigator: prof. Barbara Teresa Klajnert-Maculewicz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

New gamma-lactam analogues of homo-N-nucleosides

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Joanna Gotkowska

Uniwersytet Medyczny w Łodzi, Katedra Chemii Bioorganicznej i Biokoordynacyjnej

Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

Call: SONATA BIS 3 , Panel: NZ1

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

Isosterically modified acyclic nucleoside phosphonates

Call: OPUS 5 , Panel: NZ7

Principal investigator: prof. Andrzej Edward Wróblewski

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

The effect of long-term physical training on changes in the metabolism of nucleotides and their derivatives in blood.

Call: OPUS 5 , Panel: NZ7

Principal investigator: dr hab. Jacek Zieliński

Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu, Wydział Wychowania Fizycznego, Sportu i Rehabilitacji

New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Transformation of 5'-O-monothiophosphate nucleoside to 5'-O-monophosphate in the cell - possible metabolism of phosphoro...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr Agnieszka Krakowiak

Centrum Badań Molekularnych i Makromolekularnych PAN

Synthesis and study of spectroscopic and bilogical properties of nucleosides modyfied by new stilbene derivatives

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Przemysław Ryszard Szczeciński

Politechnika Warszawska, Wydział Chemiczny

Pronucloetides - a pathway to cellular DNA sensitization to ionizing radiation

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Magdalena Danuta Zdrowowicz

Uniwersytet Gdański, Wydział Chemii

Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Marcin Krzysztof Chmielewski

Instytut Chemii Bioorganicznej PAN

New 3,8-disubstituted purine nucleoside analogues as prospective application for research of structure and biological ac...

Call: SONATA 3 , Panel: ST5

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

Pirymidine phosphorothioate analogues of nucleotides as multifunctional regulators of P2Y6 and P2Y14 nucleotide receptor...

Call: PRELUDIUM 3 , Panel: NZ5

Principal investigator: Edyta Węgłowska

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

New reagents and methods in synthesis of modified nucleotides and their application for preparation biochemical tools an...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Stereodefined phosphorothioate analogs of DNA with incorporated LNA-type nucleosides - synthesis and properties of compl...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Jerzy Guga

Centrum Badań Molekularnych i Makromolekularnych PAN

A new gereration of anticancer pronucleotides

Call: OPUS 1 , Panel: NZ4

Principal investigator: prof. Jacek Antoni Stawiński

Instytut Chemii Bioorganicznej PAN

Chromatographic determination of nucleic acids (DNA, RNA) and their constituents (nucleosides, nucleotides, oligonuceoti...

Call: SONATA 1 , Panel: ST4

Principal investigator: dr Sylwia Studzińska

Uniwersytet Mikołaja Kopernika, Wydział Chemii, Katedra Chemii Środowiska i Bioanalityki

Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Jacek Antoni Stawiński

Instytut Chemii Bioorganicznej PAN

Antiviral activity of novel acyclic phosphonate nucleoside analogues containing the 1,2,3-triazole moiety

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr Iwona Elżbieta Głowacka

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Marcin Jarosław Ziemniak

Uniwersytet Warszawski, Wydział Fizyki

Regulation of Expression of Ecto-5'-Nucleotidase - Changes in Pathology and Therapeutic Potential

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Ryszard Tomasz Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski