Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Functional glycol nucleic acid (fun-GNA) nucleosides, nucleotides and oligos: synthesis and properties

2018/29/B/ST5/00055

Keywords:

synthesis XNA nucleosides organometallic compounds organic emitters

Descriptors:

  • ST5_23:
  • ST5_24:
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Łódzki, Wydział Chemii

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Konrad Kowalski 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 478 995 PLN

Project start date (Y-m-d): 2019-01-24

Project end date (Y-m-d): 2023-01-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spectrofluorymetr (340 000 PLN)
  2. komputer-laptop wraz z oprogramowaniem (7 000 PLN)
  3. kolumny chromatograficzne z wypełnieniem chiralnym (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (6)
  1. Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro
    Authors:
    M. Gil-Moles, S. Türck, U. Basu, A. Pettenuzzo, S. Bhattacharya, A. Rajan, X. Ma, R. Büssing, J. Wölker, H. Burmeister, H. Hoffmeister, P. Schneeberg, A. Prause, P. Lippmann, J. Kusi-Nimarko, S. Hassell-Hart, A. McGown, D. Guest, Y. Lin, A. Notaro, R. Vinck, J. Karges, K. Cariou, K. Peng, X. Qin, X. Wang, J. Skiba, Ł. Szczupak, K. Kowalski, U. Schatzschneider, C. Hemmert, H. Gornitzka, E. R. Milaeva, A. A. Nazarov, G. Gasser, J. Spencer, L. Ronconi, U. Kortz, J. Cinatl, D. Bojkova, I. Ott,
    Academic press:
    Chemistry - A European Journal (rok: 2021, tom: 27, strony: 17928-17940), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.202103258 - link to the publication
  2. Replacement of the phosphodiester backbone between canonical nucleosides with dirhenium carbonyl click" linker—a new class of luminescent organometallic dinucleoside phosphate mimics
    Authors:
    J. Skiba, A. Kowalczyk, A. Gorski, N. Dutkiewicz, M. Gapińska, J. Stróżek, K. Woźniak, D. Trzybiński, K. Kowalski
    Academic press:
    Dalton Transactions (rok: 2023, tom: 52, strony: 1551-1567), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2dt03995h - link to the publication
  3. Anthracene-thymine luminophores: Synthesis, photophysical properties, and imaging in living HeLa cells
    Authors:
    Artur Jabłoński, Aleksandra Kowalczyk, Marta A. Fik, Damian Trzybiński, Krzysztof Woźniak, Katerina Vinogradova, Sława Glińska, Valerije, Vrcek, Rafał Czerwieniec, Konrad Kowalski
    Academic press:
    Dyes and Pigments (rok: 2019, tom: 170, strony: 107554-107565), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2019.107554 - link to the publication
  4. Organometallic nucleosides - Synthesis, transformations, and applications
    Authors:
    Konrad Kowalski
    Academic press:
    Coordination Chemistry Reviews (rok: 2021, tom: 432, strony: 213705), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2020.213705 - link to the publication
  5. Redox-Active Glycol Nucleic Acid (GNA) Components: Synthesis, and Properties of the Ferrocenyl-GNA Nucleoside, Phosphoramidite, and Semicanonical Dinucleoside Phosphate
    Authors:
    Michał Piotrowicz, Aleksandra Kowalczyk, Damian Trzybiński, Krzysztof Woźniak, Konrad Kowalski
    Academic press:
    Organometallics (rok: 2020, tom: 39, strony: 813-823), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.organomet.9b00851 - link to the publication
  6. Chemistry of glycol nucleic acid (GNA): Synthesis, photophysical characterization and insight into the biological activity of phenanthrenyl GNA constituents
    Authors:
    A. Kowalczyk, M. Piotrowicz, M. Gapińska, D. Trzybiński, K. Woźniak, T. M. Golding, T. Stringer, G. S. Smith, R. Czerwieniec, K. Kowalski
    Academic press:
    Bioorganic Chemistry (rok: 2022, tom: 125, strony: 105847), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2022.105847 - link to the publication
  7. Electronic Coupling in 1,2,3-Triazole Bridged Ferrocenes and its Impact on Reactive Oxygen Species Generation and Deleterious Activity in Cancer Cells
    Authors:
    P. Biegański, E. Kovalski, N. Israel, E. Dmitrieva, D. Trzybiński, K. Woźniak, V. Vrček, M. Godel, C. Riganti, J. Kopecka, H. Lang, K. Kowalski
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, strony: 9650-9666), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c01110 - link to the publication
  8. Luminescent pyrenyl-GNA nucleosides: synthesis, photophysics and confocal microscopy studies in cancer HeLa cells
    Authors:
    Joanna Skiba, Aleksandra Kowalczyk, Marta A. Fik, Magdalena Gapińska, Damian Trzybiński, Krzysztof Woźniak, Valerije Vrcek, Rafał Czerwieniec, Konrad Kowalski
    Academic press:
    Photochemical & Photobiological Sciences (rok: 2019, tom: 18, strony: 2449-2460), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9pp00271e - link to the publication
  9. Stereo-defined ferrocenyl glycol nucleic acid (Fc-GNA) constituents: synthesis, electrochemistry, mechanism of formation, and anticancer activity studies
    Authors:
    Joanna Skiba, Aleksandra Kowalczyk, Damian Trzybiński, Krzysztof Woźniak, Valerije Vrček, Magdalena Gapińska, Konrad Kowalski
    Academic press:
    European Journal of Inorganic Chemistry (rok: 2021, tom: nd, strony: 2171-2181), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/eji.202100193 - link to the publication
  1. Organometallic Xeno-Nucleic Acid Nucleosides: Synthesis and Biological Activity
    Authors:
    Konrad Kowalski
    Conference:
    15th International Symposium on Applied Bioinorganic Chemistry (rok: 2019, ), Wydawca: Nara Kasugano International Forum "IRAKA"
    Data:
    konferencja 2-5 Czerwiec
    Status:
    Published
  2. Organometallic Xeno-Nucleic Acid nucleosides: synthesis and biological activity
    Authors:
    Konrad Kowalski
    Conference:
    7th International Symposium on Metallomics (rok: 2019, ), Wydawca: Warsaw University of Technology
    Data:
    konferencja 30.06 - 3.07.2019
    Status:
    Published
  3. Ferrocenylowe i pirenylowe komponenty glikolowych kwasów nukleinowych - aspekt syntetyczny
    Authors:
    K. Kowalski, J. Skiba, M. piotrowicz, A. Kowalczyk, M. Gapińska
    Conference:
    63 Zjazd Polskiego Towarzystwa Chemicznego (rok: 2021, ), Wydawca: PTCHm Łódź
    Data:
    konferencja 13-17 września
    Status:
    Published
  4. Functional_GNA components: chemistry and biology
    Authors:
    K. Kowalski, J. Skiba, A. Kowalczyk, M. Piotrowicz
    Conference:
    XXIV International Round Table on Nucleosides, Nucleotides and Nucleic Acids, Stockholm (rok: 2022, ), Wydawca: IRT3NA
    Data:
    konferencja 28-31 sierpnia
    Status:
    Published
  5. Ferrocenyl-GNA and pyrenyl-GNA - new class of building blocks for Xeno-nucleic acids (XNAs)
    Authors:
    Joanna Skiba, Konrad Kowalski
    Conference:
    XXII International Symposium "Advances in the chemistry of heteroorganic compounds" (rok: 2019, ), Wydawca: Center of Molecular and Macromolecular Studies Polish Academy of Sciences
    Data:
    konferencja 22 listopada
    Status:
    Published
  6. Fun-GNA nucleoside derivatives as a new class of building blocks for Xeno-nucleic acids
    Authors:
    J. Skiba, K. Kowalski, A. Kowalczyk
    Conference:
    XXIII International Symposium "Advances in the Chemistry of Heteroorganic Compounds" (rok: 2022, ), Wydawca: CBMiM PAN / PTChm Łódź
    Data:
    konferencja 28 października
    Status:
    Published

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